"Polyketide Synthases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
| Descriptor ID |
D048630
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| MeSH Number(s) |
D08.811.464.257.275 D08.811.600.715
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polyketide Synthases".
Below are MeSH descriptors whose meaning is more specific than "Polyketide Synthases".
This graph shows the total number of publications written about "Polyketide Synthases" by people in this website by year, and whether "Polyketide Synthases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polyketide Synthases" by people in Profiles.
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Matsui T, Kodama T, Mori T, Tadakoshi T, Noguchi H, Abe I, Morita H. 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases. J Biol Chem. 2017 06 02; 292(22):9117-9135.
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Mori T, Yang D, Matsui T, Hashimoto M, Morita H, Fujii I, Abe I. Structural basis for the formation of acylalkylpyrones from two ?-ketoacyl units by the fungal type III polyketide synthase CsyB. J Biol Chem. 2015 Feb 20; 290(8):5214-5225.
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Vergnolle O, Hahn F, Baerga-Ortiz A, Leadlay PF, Andexer JN. Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation. Chembiochem. 2011 May 02; 12(7):1011-4.
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O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chem Biol. 2006 Mar; 13(3):287-96.
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Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM, Spiteller D, Williams MG, Campillo N, Spencer JB, Leadlay PF. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chem Biol. 2006 Mar; 13(3):277-85.
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Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem Biol. 2005 Oct; 12(10):1145-53.