Inhibitor of Apoptosis Proteins

"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.

Descriptor ID	D051034
MeSH Number(s)	D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
Concept/Terms	Inhibitor of Apoptosis Proteins Inhibitor of Apoptosis Proteins Apoptosis Proteins Inhibitor Inhibitor-Of-Apoptosis Protein Inhibitor Of Apoptosis Protein Baculoviral Inhibitor Of Apoptosis Repeat Proteins IAP Repeat Containing Proteins IAP Protein (Apoptosis) Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat-Containing 2 Protein Baculoviral IAP Repeat Containing 2 Protein Cellular Inhibitor of Apoptosis 1 Protein IAP2 Protein c-IAP1 Protein cIAP1 Protein Inhibitor of Apoptosis 2 Protein BIRC2 Protein Baculoviral IAP Repeat Containing Protein 2

Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Inhibitor of Apoptosis Proteins [D12.776.476.075.437]

Below are MeSH descriptors whose meaning is related to "Inhibitor of Apoptosis Proteins".

Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".

Inhibitor of Apoptosis Proteins
Baculoviral IAP Repeat-Containing 3 Protein
Neuronal Apoptosis-Inhibitory Protein
X-Linked Inhibitor of Apoptosis Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.

Bar chart showing 26 publications over 13 distinct years, with a maximum of 4 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	2	2
2005	1	2	3
2006	0	1	1
2007	1	0	1
2008	0	2	2
2009	0	2	2
2010	1	1	2
2011	2	0	2
2012	0	1	1
2013	1	1	2
2014	3	0	3
2015	1	3	4

Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.

de Necochea-Campion R, Diaz Osterman CJ, Hsu HW, Fan J, Mirshahidi S, Wall NR, Chen CS. AML sensitivity to YM155 is modulated through AKT and Mcl-1. Cancer Lett. 2015 Sep 28; 366(1):44-51.

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Pannu V, Rida PC, Ogden A, Turaga RC, Donthamsetty S, Bowen NJ, Rudd K, Gupta MV, Reid MD, Cantuaria G, Walczak CE, Aneja R. HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients. Oncotarget. 2015 Mar 20; 6(8):6076-91.

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Elhag R, Mazzio EA, Soliman KF. The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. Anticancer Res. 2015 Mar; 35(3):1263-9.

View in: PubMed
Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95.

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Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One. 2014; 9(3):e92124.

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Galloway NR, Diaz Osterman CJ, Reiber K, Jutzy JM, Li F, Sui G, Soto U, Wall NR. Yin Yang 1 regulates the transcriptional repression of Survivin. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):208-13.

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Mull AN, Klar A, Navara CS. Differential localization and high expression of SURVIVIN splice variants in human embryonic stem cells but not in differentiated cells implicate a role for SURVIVIN in pluripotency. Stem Cell Res. 2014 Mar; 12(2):539-49.

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Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez RR. Obesity induced a leptin-Notch signaling axis in breast cancer. Int J Cancer. 2014 Apr 01; 134(7):1605-16.

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Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, Rose AH, Yang H, Gaudino G, Hoffmann PR, Siccardi A, Carbone M. Fowlpox-based survivin vaccination for malignant mesothelioma therapy. Int J Cancer. 2013 Aug 01; 133(3):612-23.

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Pervin S, Tran L, Urman R, Braga M, Parveen M, Li SA, Chaudhuri G, Singh R. Oxidative stress specifically downregulates survivin to promote breast tumour formation. Br J Cancer. 2013 Mar 05; 108(4):848-58.

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