Ubiquitin-Protein Ligases

"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Descriptor ID	D044767
MeSH Number(s)	D08.811.464.938.750
Concept/Terms	Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases Ligases, Ubiquitin-Protein Ubiquitin Protein Ligases E3 Ubiquitin Ligase Ligase, E3 Ubiquitin Ubiquitin Ligase, E3 Ubiquitin-Protein Ligase E3 Ligase E3, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ubiquitin Ligase E3 Ligase E3, Ubiquitin Ubiquitin-Protein Ligase Ligase, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ligase Ligase, E3

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Protein Ligases".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.

Bar chart showing 59 publications over 24 distinct years, with a maximum of 6 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1999	1	0	1
2001	1	0	1
2002	1	1	2
2003	0	1	1
2005	3	1	4
2006	1	0	1
2007	3	2	5
2008	1	1	2
2009	0	1	1
2010	2	0	2
2011	5	1	6
2012	3	0	3
2013	0	1	1
2014	0	3	3
2015	3	0	3
2016	2	1	3
2017	2	2	4
2018	5	0	5
2019	2	1	3
2020	1	0	1
2021	2	1	3
2022	1	1	2
2023	0	1	1

Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.

Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C. Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2023 Oct 24; 120(43):e2308870120.

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Singhal SK, Byun JS, Yan T, Yancey R, Caban A, Gil Hernandez S, Bufford S, Hewitt SM, Winfield J, Pradhan J, Mustkov V, McDonald JA, P?rez-Stable EJ, N?poles AM, Vohra N, De Siervi A, Yates C, Davis MB, Yang M, Tsai YC, Weissman AM, Gardner K. Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race. JCI Insight. 2022 07 08; 7(13).

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Mekbib T, Suen TC, Rollins-Hairston A, Smith K, Armstrong A, Gray C, Owino S, Baba K, Baggs JE, Ehlen JC, Tosini G, DeBruyne JP. "The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism". PLoS Genet. 2022 07; 18(7):e1010305.

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Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. J Allergy Clin Immunol Pract. 2021 07; 9(7):2885-2893.e3.

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Dixit P, Kokate SB, Poirah I, Chakraborty D, Smoot DT, Ashktorab H, Rout N, Singh SP, Bhattacharyya A. Helicobacter pylori-induced gastric cancer is orchestrated by MRCK?-mediated Siah2 phosphorylation. J Biomed Sci. 2021 Feb 03; 28(1):12.

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Liang H, Matei N, McBride DW, Xu Y, Zhou Z, Tang J, Luo B, Zhang JH. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation. 2021 Feb 02; 18(1):40.

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Przanowski P, Lou S, Tihagam RD, Mondal T, Conlan C, Shivange G, Saltani I, Singh C, Xing K, Morris BB, Mayo MW, Teixeira L, Lehmann-Che J, Tushir-Singh J, Bhatnagar S. Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Cancer Res. 2020 11 01; 80(21):4791-4804.

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Wen F, Armstrong N, Hou W, Cruz-Cosme R, Obwolo LA, Ishizuka K, Ullah H, Luo MH, Sawa A, Tang Q. Zika virus increases mind bomb 1 levels, causing degradation of pericentriolar material 1 (PCM1) and dispersion of PCM1-containing granules from the centrosome. J Biol Chem. 2019 12 06; 294(49):18742-18755.

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Mekbib T, Suen TC, Rollins-Hairston A, DeBruyne JP. The E3 Ligases Spsb1 and Spsb4 Regulate RevErba Degradation and Circadian Period. J Biol Rhythms. 2019 12; 34(6):610-621.

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Wang H, Cheung F, Stoll AC, Rockwell P, Figueiredo-Pereira ME. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1436-1450.

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