Ubiquitin-Protein Ligases

"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Descriptor ID	D044767
MeSH Number(s)	D08.811.464.938.750
Concept/Terms	Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases Ligases, Ubiquitin-Protein Ubiquitin Protein Ligases E3 Ubiquitin Ligase Ligase, E3 Ubiquitin Ubiquitin Ligase, E3 Ubiquitin-Protein Ligase E3 Ligase E3, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ubiquitin Ligase E3 Ligase E3, Ubiquitin Ubiquitin-Protein Ligase Ligase, Ubiquitin-Protein Ubiquitin Protein Ligase E3 Ligase Ligase, E3

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Protein Ligases".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.

Bar chart showing 63 publications over 25 distinct years, with a maximum of 7 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1999	1	0	1
2001	1	0	1
2002	1	1	2
2003	0	1	1
2005	3	1	4
2006	1	0	1
2007	3	2	5
2008	1	1	2
2009	0	1	1
2010	2	0	2
2011	5	2	7
2012	3	0	3
2013	0	1	1
2014	0	3	3
2015	3	0	3
2016	2	1	3
2017	2	2	4
2018	5	0	5
2019	2	1	3
2020	1	0	1
2021	2	1	3
2022	1	2	3
2023	0	1	1
2024	2	0	2

Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.

Novelli F, Yoshikawa Y, Vitto VAM, Modesti L, Minaai M, Pastorino S, Emi M, Kim JH, Kricek F, Bai F, Onuchic JN, Bononi A, Suarez JS, Tanji M, Favaron C, Zolondick AA, Xu R, Takanishi Y, Wang Z, Sakamoto G, Gaudino G, Grzymski J, Grosso F, Schrump DS, Pass HI, Atanesyan L, Smout J, Savola S, Sarin KY, Abolhassani H, Hammarstr?m L, Pan-Hammarstr?m Q, Giorgi C, Pinton P, Yang H, Carbone M. Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2405231121.

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Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C. Mechanism of ?-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase. Nat Commun. 2024 Apr 26; 15(1):3558.

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Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C. Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2023 Oct 24; 120(43):e2308870120.

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Liu Y, Liu R, Huang L, Zuo G, Dai J, Gao L, Shi H, Fang Y, Lu Q, Okada T, Wang Z, Hu X, Lenahan C, Tang J, Xiao J, Zhang JH. Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats. Oxid Med Cell Longev. 2022; 2022:7727616.

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Singhal SK, Byun JS, Yan T, Yancey R, Caban A, Gil Hernandez S, Bufford S, Hewitt SM, Winfield J, Pradhan J, Mustkov V, McDonald JA, P?rez-Stable EJ, N?poles AM, Vohra N, De Siervi A, Yates C, Davis MB, Yang M, Tsai YC, Weissman AM, Gardner K. Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race. JCI Insight. 2022 07 08; 7(13).

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Mekbib T, Suen TC, Rollins-Hairston A, Smith K, Armstrong A, Gray C, Owino S, Baba K, Baggs JE, Ehlen JC, Tosini G, DeBruyne JP. "The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism". PLoS Genet. 2022 07; 18(7):e1010305.

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Patel T, Henrickson SE, Moser EK, Field NS, Maurer K, Dawany N, Conrad M, Bunin N, Freedman JL, Heimall J, Arnold DE, Wang J, Markowitz JE, Payne-Poff SB, Williams KW, Russo PA, Wherry EJ, Devoto M, Oliver P, Sullivan KE, Kelsen JR. Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation. J Allergy Clin Immunol Pract. 2021 07; 9(7):2885-2893.e3.

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Dixit P, Kokate SB, Poirah I, Chakraborty D, Smoot DT, Ashktorab H, Rout N, Singh SP, Bhattacharyya A. Helicobacter pylori-induced gastric cancer is orchestrated by MRCK?-mediated Siah2 phosphorylation. J Biomed Sci. 2021 Feb 03; 28(1):12.

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Liang H, Matei N, McBride DW, Xu Y, Zhou Z, Tang J, Luo B, Zhang JH. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation. 2021 Feb 02; 18(1):40.

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Przanowski P, Lou S, Tihagam RD, Mondal T, Conlan C, Shivange G, Saltani I, Singh C, Xing K, Morris BB, Mayo MW, Teixeira L, Lehmann-Che J, Tushir-Singh J, Bhatnagar S. Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. Cancer Res. 2020 11 01; 80(21):4791-4804.

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