Ubiquitin-Conjugating Enzymes

"Ubiquitin-Conjugating Enzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATING ENZYMES. They transfer ubiquitin to the LYSINE of a substrate protein with the assistance of UBIQUITIN-PROTEIN LIGASES.

Descriptor ID	D044763
MeSH Number(s)	D08.811.464.938.500
Concept/Terms	Ubiquitin-Conjugating Enzymes Ubiquitin-Conjugating Enzymes Enzymes, Ubiquitin-Conjugating Ubiquitin Conjugating Enzymes Ubiquitin-Conjugating Enzyme E2 E2, Ubiquitin-Conjugating Enzyme Enzyme E2, Ubiquitin-Conjugating Ubiquitin Conjugating Enzyme E2 HHR6 Protein HHR6 Protein

Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Conjugating Enzymes".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Conjugating Enzymes [D08.811.464.938.500]

Below are MeSH descriptors whose meaning is related to "Ubiquitin-Conjugating Enzymes".

Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Conjugating Enzymes".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ubiquitin-Conjugating Enzymes" by people in this website by year, and whether "Ubiquitin-Conjugating Enzymes" was a major or minor topic of these publications.

Bar chart showing 13 publications over 11 distinct years, with a maximum of 2 publications in 2011 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2004	0	1	1
2005	1	0	1
2007	1	0	1
2009	1	0	1
2010	0	1	1
2011	2	0	2
2012	1	0	1
2014	1	0	1
2018	1	1	2
2021	1	0	1

Below are the most recent publications written about "Ubiquitin-Conjugating Enzymes" by people in Profiles.

Wang B, Qian JY, Tang TT, Lin LL, Yu N, Guo HL, Ni WJ, Lv LL, Wen Y, Li ZL, Wu M, Cao JY, Liu BC. VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy. Diabetes. 2021 11; 70(11):2639-2651.

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Ullah K, Zubia E, Narayan M, Yang J, Xu G. Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset. FEBS J. 2019 06; 286(11):2018-2034.

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Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Nat Commun. 2018 10 22; 9(1):4385.

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Varadaraj A, Mattoscio D, Chiocca S. SUMO Ubc9 enzyme as a viral target. IUBMB Life. 2014 Jan; 66(1):27-33.

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Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarc?n-Riquelme ME, Alarc?n GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vil? LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun. 2012 Jul; 13(5):380-7.

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Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN. Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins. J Cell Physiol. 2011 Dec; 226(12):3355-67.

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Helms KM, Wilson RC, Ogungbe IV, Setzer WN, Twigg PD. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011 Oct; 6(10):1411-6.

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Mittal MK, Singh K, Misra S, Chaudhuri G. SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem. 2011 Jan 07; 286(1):469-79.

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Xu J, Watkins T, Reddy A, Reddy ES, Rao VN. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. Int J Oncol. 2009 Apr; 34(4):939-49.

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D?az-Blanco NL, Rodr?guez-Medina JR. Dosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1. Yeast. 2007 Apr; 24(4):343-55.

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