Microsatellite Instability

"Microsatellite Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.

Descriptor ID	D053842
MeSH Number(s)	C23.550.362.590 G05.365.590.335.590 G05.370.590
Concept/Terms	Microsatellite Instability Microsatellite Instability Instability, Microsatellite Replication Error Phenotype Replication Error Phenotype Error Phenotype, Replication Error Phenotypes, Replication Phenotype, Replication Error Phenotypes, Replication Error Replication Error Phenotypes

Below are MeSH descriptors whose meaning is more general than "Microsatellite Instability".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Genomic Instability [C23.550.362]
Microsatellite Instability [C23.550.362.590]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Genomic Instability [G05.365.590.335]
Microsatellite Instability [G05.365.590.335.590]
Genomic Instability [G05.370]
Microsatellite Instability [G05.370.590]

Below are MeSH descriptors whose meaning is related to "Microsatellite Instability".

Below are MeSH descriptors whose meaning is more specific than "Microsatellite Instability".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Microsatellite Instability" by people in this website by year, and whether "Microsatellite Instability" was a major or minor topic of these publications.

Bar chart showing 28 publications over 18 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2008	2	1	3
2009	1	1	2
2010	1	0	1
2011	0	1	1
2012	1	3	4
2013	0	2	2
2014	1	1	2
2015	0	1	1
2016	1	0	1
2017	0	1	1
2018	1	1	2
2019	0	1	1
2020	0	1	1
2021	1	0	1
2023	0	1	1
2024	0	1	1
2025	1	1	2

Below are the most recent publications written about "Microsatellite Instability" by people in Profiles.

Matejcic M, Teer JK, Hoehn HJ, Diaz DB, Shankar K, Gong J, Nguyen NT, Loro?a NC, Coppola D, Fulmer CG, Saglam O, Jiang K, Cress WD, Mu?oz-Antonia T, Flores I, Gordi?n ER, Oliveras Torres JA, Felder SI, Sanchez J, Fleming JB, Siegel EM, Freedman JA, Dutil J, Stern MC, Fridley BL, Figueiredo JC, Schmit SL. Colorectal Tumors in Diverse Patient Populations Feature a Spectrum of Somatic Mutational Profiles. Cancer Res. 2025 May 15; 85(10):1928-1944.

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Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, Collins C, Bansal R, Buker SM, Case A, Liu J, Yao S, Sparling BA, Sickmier EA, Silver SJ, Blakemore SJ, Boriack-Sjodin PA, Duncan KW, Ribich S, Copeland RA. A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair. Cancer Res. 2025 Feb 17; 85(4):758-776.

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Rashid M, Rashid R, Gadewal N, Carethers JM, Koi M, Brim H, Ashktorab H. High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer. Neoplasia. 2024 03; 49:100970.

View in: PubMed
Perez-Mayoral J, Gonzalez-Pons M, Centeno-Girona H, Montes-Rodr?guez IM, Soto-Salgado M, Su?rez B, Rodr?guez N, Col?n G, Sevilla J, Jorge D, Llor X, Xicola RM, Toro DH, Tous-L?pez L, Torres-Torres M, Reyes JS, L?pez-Acevedo N, Goel A, Rodr?guez-Quilichini S, Cruz-Correa M. Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico. Genes (Basel). 2023 04 11; 14(4).

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Amin A, Farrukh A, Murali C, Soleimani A, Praz F, Graziani G, Brim H, Ashktorab H. Saffron and Its Major Ingredients' Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability. Molecules. 2021 Jun 24; 26(13).

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Sierra I, P?rez-Mayoral J, Rosado K, Maldonado V, Alicea-Zambrana K, Reyes JS, Torres M, Tous L, Lop?z-Acevedo N, Diaz-Algorr? Y, Carlo-Chevere V, Rodriguez-Quilichini S, Cruz-Correa M. Implementation of Universal Colorectal Cancer Screening for Lynch Syndrome in Hispanics Living in Puerto Rico. J Racial Ethn Health Disparities. 2021 Oct; 8(5):1185-1191.

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Ashktorab H, Delker D, Kanth P, Goel A, Carethers JM, Brim H. Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort. Gastroenterology. 2019 08; 157(2):572-574.

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Bhaskaran N, Luu J, Kelley ST, Khan MW, Mamindla P, McGuire KL. A new method for discovering EMAST sequences in animal models of cancer. Sci Rep. 2018 09 13; 8(1):13764.

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Rever?n D, L?pez C, Guti?rrez S, Sayegh ZE, Antonia T, Dutil J, Malafa M, Coppola D. Frequency of Mismatch Repair Protein Deficiency in a Puerto Rican Population with Colonic Adenoma and Adenocarcinoma. Cancer Genomics Proteomics. 2018 Jul-Aug; 15(4):265-271.

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Akbari MR, Zhang S, Cragun D, Lee JH, Coppola D, McLaughlin J, Risch HA, Rosen B, Shaw P, Sellers TA, Schildkraut J, Narod SA, Pal T. Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens. Fam Cancer. 2017 07; 16(3):351-355.

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