Genomic Instability

"Genomic Instability" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An increased tendency of the GENOME to acquire MUTATIONS when various processes involved in maintaining and replicating the genome are dysfunctional.

Descriptor ID	D042822
MeSH Number(s)	C23.550.362 G05.365.590.335 G05.370
Concept/Terms	Genomic Instability Genomic Instability Genomic Instabilities Instabilities, Genomic Instability, Genomic Genome Instability Genome Instabilities Instabilities, Genome Instability, Genome Genomic Stability Genomic Stability Genomic Stabilities Stabilities, Genomic Stability, Genomic Genome Stability Genome Stabilities Stabilities, Genome Stability, Genome

Below are MeSH descriptors whose meaning is more general than "Genomic Instability".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Genomic Instability [C23.550.362]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Genomic Instability [G05.365.590.335]
Genomic Instability [G05.370]

Below are MeSH descriptors whose meaning is related to "Genomic Instability".

Below are MeSH descriptors whose meaning is more specific than "Genomic Instability".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genomic Instability" by people in this website by year, and whether "Genomic Instability" was a major or minor topic of these publications.

Bar chart showing 30 publications over 14 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2006	1	2	3
2008	2	0	2
2009	1	2	3
2010	1	1	2
2011	1	2	3
2013	1	2	3
2016	2	0	2
2018	1	0	1
2019	0	1	1
2020	2	2	4
2021	0	1	1
2022	0	3	3
2024	0	1	1

Below are the most recent publications written about "Genomic Instability" by people in Profiles.

Novelli F, Yoshikawa Y, Vitto VAM, Modesti L, Minaai M, Pastorino S, Emi M, Kim JH, Kricek F, Bai F, Onuchic JN, Bononi A, Suarez JS, Tanji M, Favaron C, Zolondick AA, Xu R, Takanishi Y, Wang Z, Sakamoto G, Gaudino G, Grzymski J, Grosso F, Schrump DS, Pass HI, Atanesyan L, Smout J, Savola S, Sarin KY, Abolhassani H, Hammarstr?m L, Pan-Hammarstr?m Q, Giorgi C, Pinton P, Yang H, Carbone M. Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2405231121.

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Yin Q, Zhao YJ, Ni WJ, Tang TT, Wang Y, Cao JY, Yin D, Wen Y, Li ZL, Zhang YL, Jiang W, Zhang Y, Lu XY, Zhang AQ, Gan WH, Lv LL, Liu BC, Wang B. MiR-155 deficiency protects renal tubular epithelial cells from telomeric and genomic DNA damage in cisplatin-induced acute kidney injury. Theranostics. 2022; 12(10):4753-4766.

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Kawamura A, Yoshida S, Aoki K, Shimoyama Y, Yamada K, Yoshida K. DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage. J Cell Sci. 2022 06 01; 135(11).

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Debnath S, Lu X, Lal A, Sharma S. Genome-wide investigations on regulatory functions of RECQ1 helicase. Methods. 2022 08; 204:263-268.

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Zhan S, Siu J, Wang Z, Yu H, Bezabeh T, Deng Y, Du W, Fei P. Focal Point of Fanconi Anemia Signaling. Int J Mol Sci. 2021 Nov 30; 22(23).

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Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, Carparelli L, Ferro A, Nasu M, Kim JH, Suarez JS, Xu R, Tanji M, Takinishi Y, Minaai M, Novelli F, Pagano I, Gaudino G, Pass HI, Groden J, Grzymski JJ, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H, Carbone M. Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33466-33473.

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Gorini F, Scala G, Cooke MS, Majello B, Amente S. Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability. DNA Repair (Amst). 2021 01; 97:103027.

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Ma C, Hokutan K, Shen Y, Nepal M, Kim JH, Zhang J, Fei P. TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response. Aging (Albany NY). 2020 10 24; 12(20):20268-20284.

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Debnath S, Sharma S. RECQ1 Helicase in Genomic Stability and Cancer. Genes (Basel). 2020 06 05; 11(6).

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Homchan A, Sukted J, Mongkolsuk S, Jeruzalmi D, Matangkasombut O, Pakotiprapha D. Wss1 homolog from Candida albicans and its role in DNA-protein crosslink tolerance. Mol Microbiol. 2020 09; 114(3):409-422.

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