Necrosis

"Necrosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

Descriptor ID	D009336
MeSH Number(s)	C23.550.717 G04.146.638
Concept/Terms	Necrosis Necrosis Necroses

Below are MeSH descriptors whose meaning is more general than "Necrosis".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Necrosis [C23.550.717]
Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Necrosis [G04.146.638]

Below are MeSH descriptors whose meaning is related to "Necrosis".

Below are MeSH descriptors whose meaning is more specific than "Necrosis".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Necrosis" by people in this website by year, and whether "Necrosis" was a major or minor topic of these publications.

Bar chart showing 44 publications over 20 distinct years, with a maximum of 6 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2000	0	1	1
2002	0	1	1
2003	0	1	1
2005	0	1	1
2006	0	3	3
2007	0	2	2
2009	1	2	3
2010	0	3	3
2011	1	3	4
2012	2	4	6
2013	0	3	3
2014	0	1	1
2015	1	1	2
2017	0	1	1
2018	1	2	3
2019	0	3	3
2021	0	2	2
2023	0	2	2

Below are the most recent publications written about "Necrosis" by people in Profiles.

Montague T, Weaver SB, Wingate LT. Extravasation of Non-Cytotoxic Drugs in Older People. Sr Care Pharm. 2023 Nov 01; 38(11):457-464.

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Iji OT, Ajibade TO, Esan OO, Awoyomi OV, Oyagbemi AA, Adetona MO, Omobowale TO, Yakubu MA, Oguntibeju OO, Nwulia E. Ameliorative effects of glycine on cobalt chloride-induced hepato-renal toxicity in rats. Animal Model Exp Med. 2023 04; 6(2):168-177.

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Lv LL, Wang C, Li ZL, Cao JY, Zhong X, Feng Y, Chen J, Tang TT, Ni HF, Wu QL, Wang B, Lan HY, Liu BC. SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury. Cell Death Dis. 2021 09 23; 12(10):866.

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Mendelowitz ZZ, Idrizi A, Mano I. Live Animal Imaging and Cell Sorting Methods for Investigating Neurodegeneration in a C. elegans Excitotoxic Necrosis Model. J Vis Exp. 2021 01 22; (167).

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Goren L, Zhang G, Kaushik S, Breslin PAS, Du YN, Foster DA. (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLoS One. 2019; 14(8):e0216024.

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Tiwari S, Casey R, Goulding CW, Hingley-Wilson S, Jacobs WR. Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1. Microbiol Spectr. 2019 05; 7(3).

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Gutierrez DA, DeJesus RE, Contreras L, Rodriguez-Palomares IA, Villanueva PJ, Balderrama KS, Monterroza L, Larragoity M, Varela-Ramirez A, Aguilera RJ. A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation. Cell Biol Toxicol. 2019 12; 35(6):503-519.

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Feldmann KG, Chowdhury A, Becker JL, McAlpin N, Ahmed T, Haider S, Richard Xia JX, Diaz K, Mehta MG, Mano I. Non-canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis. J Neurochem. 2019 02; 148(4):531-549.

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Thompson SA, Aggarwal A, Singh S, Adam AP, Tome JPC, Drain CM. Compromising the plasma membrane as a secondary target in photodynamic therapy-induced necrosis. Bioorg Med Chem. 2018 10 01; 26(18):5224-5228.

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Chapa-Dubocq X, Makarov V, Javadov S. Simple kinetic model of mitochondrial swelling in cardiac cells. J Cell Physiol. 2018 07; 233(7):5310-5321.

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