Autophagy

"Autophagy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The segregation and degradation of cytoplasmic constituents by AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.

Descriptor ID	D001343
MeSH Number(s)	G04.146.399 G04.417.350.091
Concept/Terms	Autophagy Autophagy Autophagies Macro-autophagy Macro autophagy Macro-autophagies Autophagy, Cellular Autophagies, Cellular Cellular Autophagies Cellular Autophagy Macroautophagy Macroautophagies Autophagocytosis Programmed Cell Death, Type II Programmed Cell Death, Type II Autophagic Cell Death Autophagic Cell Deaths Cell Death, Autophagic Cell Deaths, Autophagic Death, Autophagic Cell Deaths, Autophagic Cell Autophagic Programmed Cell Death

Below are MeSH descriptors whose meaning is more general than "Autophagy".

Biological Sciences [G]
Cell Physiological Phenomena [G04]
Cell Death [G04.146]
Autophagy [G04.146.399]
Endocytosis [G04.417]
Phagocytosis [G04.417.350]
Autophagy [G04.417.350.091]

Below are MeSH descriptors whose meaning is related to "Autophagy".

Below are MeSH descriptors whose meaning is more specific than "Autophagy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Autophagy" by people in this website by year, and whether "Autophagy" was a major or minor topic of these publications.

Bar chart showing 107 publications over 20 distinct years, with a maximum of 10 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2007	4	1	5
2008	2	2	4
2009	1	1	2
2010	6	0	6
2011	4	5	9
2012	2	7	9
2013	4	4	8
2014	2	1	3
2015	2	4	6
2016	6	4	10
2017	3	3	6
2018	6	1	7
2019	3	3	6
2020	2	4	6
2021	4	3	7
2022	1	4	5
2023	0	2	2
2024	2	0	2
2025	0	3	3

Below are the most recent publications written about "Autophagy" by people in Profiles.

Gonz?lez-Ch?vez SA, Chaparro-Barrera E, Loya-Rivera M, Rodr?guez-Castillo AJ, Prieto-Carrasco R, Aguilera RJ, Betancourt AP, Mohl JE, Ruizesparza-Hinojos DA, Ram?rez-P?rez SJ, Berm?dez M, Pacheco-Tena C. Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis. Neuropeptides. 2025 Aug; 112:102533.

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Battle D, Qiu X, Alex M, Rivers L, Hamilton JAG, Takayama S, Zhao X. Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity. Cells. 2025 02 27; 14(5).

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Yang C, Pang X, Teng S, Wilson S, Gu X, Xie G. MYC Overexpression Enhances Sensitivity to MEK Inhibition in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2025 Jan 12; 26(2).

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Celada SI, Li G, Celada LJ, Kanagasabai T, Lu W, Brown LK, Mark ZA, Izban MG, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Wang X, Chen Z. Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2. Sci Signal. 2024 12 17; 17(867):eadk4122.

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Ijatuyi TT, Lawal AO, Akinjiyan MO, Ojo FM, Koledoye OF, Agboola OO, Dahunsi DT, Folorunso IM, Elekofehinti OO. Effects of Bryophyllum pinnatum on Dysfunctional Autophagy in Rats Lungs Exposed to Zinc Oxide Nanoparticles. Int Immunopharmacol. 2024 Nov 15; 141:113005.

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Ye Y, Reyes AM, Li C, White JC, Gardea-Torresdey JL. Mechanistic Insight into the Internalization, Distribution, and Autophagy Process of Manganese Nanoparticles in Capsicum annuum L.: Evidence from Orthogonal Microscopic Analysis. Environ Sci Technol. 2023 07 04; 57(26):9773-9781.

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Pajarillo E, Kim S, Digman A, Dutton M, Son DS, Aschner M, Lee E. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023 07; 299(7):104879.

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Ahmed SA, Mendonca P, Elhag R, Soliman KFA. Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation. Int J Mol Sci. 2022 Dec 17; 23(24).

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Ortega MA, Villiger RK, Harrison-Chau M, Lieu S, Tamashiro KK, Lee AJ, Fujimoto BA, Patwardhan GY, Kepler J, Fogelgren B. Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-?B signaling. Dis Model Mech. 2022 10 01; 15(10).

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Hu F, Peng Y, Chang S, Luo X, Yuan Y, Zhu X, Xu Y, Du K, Chen Y, Deng S, Yu F, Feng X, Fan X, Ashktorab H, Smoot D, Meltzer SJ, Li S, Wei Y, Zhang X, Jin Z. Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma. Cancer Lett. 2022 10 01; 545:215826.

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