Codon, Nonsense

"Codon, Nonsense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Descriptor ID	D018389
MeSH Number(s)	D13.444.735.544.355.250.235 G05.360.335.355.250.235 G05.365.590.195
Concept/Terms	Codon, Nonsense Codon, Nonsense Premature Termination Codon Codon, Premature Termination Codons, Premature Termination Premature Termination Codons Termination Codon, Premature Termination Codons, Premature Premature Stop Codon Codon, Premature Stop Codons, Premature Stop Premature Stop Codons Stop Codon, Premature Stop Codons, Premature Nonsense Codon Codons, Nonsense Nonsense Codons Codon, Termination, Premature Mutation, Nonsense Mutation, Nonsense Mutations, Nonsense Nonsense Mutations Nonsense Mutation Ochre Nonsense Codon Ochre Nonsense Codon Codon, Ochre Nonsense Codons, Ochre Nonsense Nonsense Codon, Ochre Nonsense Codons, Ochre Ochre Nonsense Codons Ochre Nonsense Mutation Ochre Nonsense Mutation Mutation, Ochre Nonsense Mutations, Ochre Nonsense Nonsense Mutation, Ochre Nonsense Mutations, Ochre Ochre Nonsense Mutations Amber Nonsense Mutation Amber Nonsense Mutation Amber Nonsense Mutations Mutation, Amber Nonsense Mutations, Amber Nonsense Nonsense Mutation, Amber Nonsense Mutations, Amber Opal Nonsense Mutation Opal Nonsense Mutation Mutation, Opal Nonsense Mutations, Opal Nonsense Nonsense Mutation, Opal Nonsense Mutations, Opal Opal Nonsense Mutations Amber Nonsense Codon Amber Nonsense Codon Amber Nonsense Codons Codon, Amber Nonsense Codons, Amber Nonsense Nonsense Codons, Amber Nonsense Codon, Amber Codon, Unassigned Codon, Unassigned Codons, Unassigned Unassigned Codons Unassigned Codon Opal Nonsense Codon Opal Nonsense Codon Codon, Opal Nonsense Codons, Opal Nonsense Nonsense Codon, Opal Nonsense Codons, Opal Opal Nonsense Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Nonsense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Codon, Nonsense [D13.444.735.544.355.250.235]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Codon, Nonsense [G05.360.335.355.250.235]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Codon, Nonsense [G05.365.590.195]

Below are MeSH descriptors whose meaning is more specific than "Codon, Nonsense".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Nonsense" by people in this website by year, and whether "Codon, Nonsense" was a major or minor topic of these publications.

Bar chart showing 16 publications over 13 distinct years, with a maximum of 2 publications in 2013 and 2016 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2007	0	1	1
2008	0	1	1
2009	1	0	1
2010	1	0	1
2011	0	1	1
2012	0	1	1
2013	0	2	2
2016	0	2	2
2017	0	1	1
2021	0	1	1
2023	0	2	2
2024	0	1	1

Below are the most recent publications written about "Codon, Nonsense" by people in Profiles.

Reyes-Nava NG, Paz D, Pinales BE, Perez I, Gil CB, Gonzales AV, Grajeda BI, Estevao IL, Ellis CC, Castro VL, Quintana AM. Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development. Differentiation. 2024 Jul-Aug; 138:100790.

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Diaz Quiroz JF, Ojha N, Shayhidin EE, De Silva D, Dabney J, Lancaster A, Coull J, Milstein S, Fraley AW, Brown CR, Rosenthal JJC. Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing. Nucleic Acids Res. 2023 04 24; 51(7):e41.

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Castro VL, Paz D, Virrueta V, Estevao IL, Grajeda BI, Ellis CC, Quintana AM. Missense and nonsense mutations of the zebrafish hcfc1a gene result in contrasting mTor and radial glial phenotypes. Gene. 2023 May 15; 864:147290.

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Salanga CM, Salanga MC. Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants. Int J Mol Sci. 2021 Mar 27; 22(7).

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Vallecillo-Viejo IC, Liscovitch-Brauer N, Montiel-Gonzalez MF, Eisenberg E, Rosenthal JJC. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme. RNA Biol. 2018 01 02; 15(1):104-114.

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Montiel-Gonz?lez MF, Vallecillo-Viejo IC, Rosenthal JJ. An efficient system for selectively altering genetic information within mRNAs. Nucleic Acids Res. 2016 12 01; 44(21):e157.

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Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 05 01; 9(5):585-96.

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Montiel-Gonzalez MF, Vallecillo-Viejo I, Yudowski GA, Rosenthal JJ. Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18285-90.

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Price EP, Sarovich DS, Mayo M, Tuanyok A, Drees KP, Kaestli M, Beckstrom-Sternberg SM, Babic-Sternberg JS, Kidd TJ, Bell SC, Keim P, Pearson T, Currie BJ. Within-host evolution of Burkholderia pseudomallei over a twelve-year chronic carriage infection. mBio. 2013 Jul 16; 4(4).

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Conley ME, Dobbs AK, Quintana AM, Bosompem A, Wang YD, Coustan-Smith E, Smith AM, Perez EE, Murray PJ. Agammaglobulinemia and absent B lineage cells in a patient lacking the p85a subunit of PI3K. J Exp Med. 2012 Mar 12; 209(3):463-70.

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