Mutagenesis, Insertional

"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

Descriptor ID	D016254
MeSH Number(s)	E05.393.420.601.550 G05.365.590.575 G05.558.550
Concept/Terms	Mutagenesis, Insertional Mutagenesis, Insertional Insertional Mutagenesis Sequence Insertion Sequence Insertion Insertion, Sequence Insertions, Sequence Sequence Insertions Viral Insertional Mutagenesis Viral Insertional Mutagenesis Insertional Mutagenesis, Viral Mutagenesis, Viral Insertional Linker-Insertion Mutagenesis Linker-Insertion Mutagenesis Linker Insertion Mutagenesis Mutagenesis, Linker-Insertion Gene Insertion Gene Insertion Gene Insertions Insertion, Gene Insertions, Gene Insertion Mutation Insertion Mutation Insertion Mutations Mutation, Insertion Mutations, Insertion Insertional Activation Insertional Activation Activation, Insertional Activations, Insertional Insertional Activations Mutagenesis, Cassette Mutagenesis, Cassette Cassette Mutagenesis

Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Insertional".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Protein Engineering [E05.393.420.601]
Mutagenesis, Insertional [E05.393.420.601.550]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Mutagenesis, Insertional [G05.365.590.575]
Mutagenesis [G05.558]
Mutagenesis, Insertional [G05.558.550]

Below are MeSH descriptors whose meaning is related to "Mutagenesis, Insertional".

Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Insertional".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in this website by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publications.

Bar chart showing 29 publications over 15 distinct years, with a maximum of 4 publications in 2003 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2003	1	3	4
2004	0	2	2
2005	1	1	2
2006	0	1	1
2007	1	1	2
2008	1	0	1
2009	3	0	3
2010	0	3	3
2011	0	1	1
2012	0	4	4
2015	0	1	1
2017	0	2	2
2019	1	0	1
2024	0	1	1

Below are the most recent publications written about "Mutagenesis, Insertional" by people in Profiles.

Aki J, Papp SB, Polk B, Jeffreys S, Tompkins MP, Kalalah AA, Eppinger M, Zhang G, Guentzel MN, Chambers JP, Arulanandam BP, Yu JJ. Characterization of Pilin A and Thioredoxin A Mutant Strains of Acinetobacter baumannii, From a Transposon Insertion Library, for Pili Production and Virulence-Associated Properties. Microbiologyopen. 2025 Dec; 14(6):e70183.

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Short JE, Sharek L, Meckler JF, Stoytchev I, Tran CT, Errard C, Hew BE, Johnson BE, Waller DF, Xie S, Higgins JJ, Tabibiazar R, Owens JB. Gene-sized DNA insertion at genomic safe harbors in human cells using a site-directed transposase. Nucleic Acids Res. 2025 Nov 26; 53(22).

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Hew BE, Gupta S, Sato R, Waller DF, Stoytchev I, Short JE, Sharek L, Tran CT, Badran AH, Owens JB. Directed evolution of hyperactive integrases for site specific insertion of transgenes. Nucleic Acids Res. 2024 Aug 12; 52(14):e64.

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Asada H, Tomiyasu H, Okada K, Chambers JK, Goto-Koshino Y, Uchida K, Kagawa Y, Ohno K, Tsujimoto H. Clinical significance of the two-base insertion mutation in the TP53 gene in canine histiocytic sarcoma. Res Vet Sci. 2019 Jun; 124:57-60.

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Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Alml?f JC, Acevedo-V?squez EM, Alarc?n GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la R?a Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frosteg?rd J, Garc?a MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kov?cs L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Cece?a MA, Mart?n J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sj?wall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusi?-Luna T, Vasconcelos C, Vil? LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syv?nen AC, R?nnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarc?n-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021.

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C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D'Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nat Neurosci. 2017 Apr; 20(4):602-611.

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Ou HY, Kuang SN, He X, Molgora BM, Ewing PJ, Deng Z, Osby M, Chen W, Xu HH. Complete genome sequence of hypervirulent and outbreak-associated Acinetobacter baumannii strain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors. Sci Rep. 2015 Mar 02; 5:8643.

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Marh J, Stoytcheva Z, Urschitz J, Sugawara A, Yamashiro H, Owens JB, Stoytchev I, Pelczar P, Yanagimachi R, Moisyadi S. Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19184-9.

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Eppinger M, Radnedge L, Andersen G, Vietri N, Severson G, Mou S, Ravel J, Worsham PL. Novel plasmids and resistance phenotypes in Yersinia pestis: unique plasmid inventory of strain Java 9 mediates high levels of arsenic resistance. PLoS One. 2012; 7(3):e32911.

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Fixen KR, Janakiraman A, Garrity S, Slade DJ, Gray AN, Karahan N, Hochschild A, Goldberg MB. Genetic reporter system for positioning of proteins at the bacterial pole. mBio. 2012; 3(2).

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