Amino Acid Substitution

"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

Descriptor ID	D019943
MeSH Number(s)	E05.393.420.601.035 G05.558.109
Concept/Terms	Amino Acid Substitution Amino Acid Substitution Amino Acid Substitutions Substitution, Amino Acid Substitutions, Amino Acid

Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Genetic Engineering [E05.393.420]
Protein Engineering [E05.393.420.601]
Amino Acid Substitution [E05.393.420.601.035]
Biological Sciences [G]
Genetic Phenomena [G05]
Mutagenesis [G05.558]
Amino Acid Substitution [G05.558.109]

Below are MeSH descriptors whose meaning is related to "Amino Acid Substitution".

Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.

Bar chart showing 103 publications over 24 distinct years, with a maximum of 11 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	2	2
2000	1	1	2
2001	1	3	4
2002	0	3	3
2003	1	6	7
2004	3	6	9
2005	0	3	3
2006	0	7	7
2007	0	6	6
2008	0	5	5
2009	0	4	4
2010	2	9	11
2011	1	4	5
2012	0	5	5
2013	1	7	8
2014	0	2	2
2015	0	2	2
2016	0	2	2
2017	0	8	8
2018	0	1	1
2019	0	4	4
2020	1	0	1
2021	0	1	1

Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.

Piserchio A, Long K, Lee K, Kumar EA, Abzalimov R, Dalby KN, Ghose R. Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation. Protein Sci. 2021 06; 30(6):1221-1234.

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Stokes ES, Gilchrist ML, Calhoun DH. Prediction of improved therapeutics for fabry disease patients generated by mutagenesis of the a-galactosidase A active site, dimer interface, and glycosylation region. Protein Expr Purif. 2020 11; 175:105710.

View in: PubMed
Khayat R, Wen K, Alimova A, Gavrilov B, Katz A, Galarza JM, Gottlieb P. Structural characterization of the PCV2d virus-like particle at 3.3?? resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes. Virology. 2019 11; 537:186-197.

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Guilherme JPLF, Bigliassi M, Lancha Junior AH. Association study of SLC6A2 gene Thr99Ile variant (rs1805065) with athletic status in the Brazilian population. Gene. 2019 Jul 30; 707:53-57.

View in: PubMed
Hernandez JA, Castro VL, Reyes-Nava N, Montes LP, Quintana AM. Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood Adv. 2019 04 23; 3(8):1244-1254.

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Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with ?-lactams. Int J Antimicrob Agents. 2019 May; 53(5):620-628.

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Hepp CM, Cocking JH, Valentine M, Young SJ, Damian D, Samuels-Crow KE, Sheridan K, Fofanov VY, Furstenau TN, Busch JD, Erickson DE, Lancione RC, Smith K, Will J, Townsend J, Keim PS, Engelthaler DM. Phylogenetic analysis of West Nile Virus in Maricopa County, Arizona: Evidence for dynamic behavior of strains in two major lineages in the American Southwest. PLoS One. 2018; 13(11):e0205801.

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Zhang DL, Wu J, Shah BN, Greut?laers KC, Ghosh MC, Ollivierre H, Su XZ, Thuma PE, Bedu-Addo G, Mockenhaupt FP, Gordeuk VR, Rouault TA. Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. Science. 2018 03 30; 359(6383):1520-1523.

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Zhao ZM, Campbell MC, Li N, Lee DSW, Zhang Z, Townsend JP. Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence. Mol Biol Evol. 2017 Nov 01; 34(11):3006-3022.

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Bhattacharya S, Reddy D, Jani V, Gadewal N, Shah S, Reddy R, Bose K, Sonavane U, Joshi R, Smoot D, Ashktorab H, Gupta S. Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics. Epigenetics Chromatin. 2017 10 18; 10(1):48.

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