"Frameshift Mutation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
| Descriptor ID |
D016368
|
| MeSH Number(s) |
G05.365.590.265
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| Concept/Terms |
Frameshift Mutation- Frameshift Mutation
- Frameshift Mutations
- Mutations, Frameshift
- Out-of-Frame Mutation
- Mutation, Out-of-Frame
- Mutations, Out-of-Frame
- Out of Frame Mutation
- Out-of-Frame Mutations
- Frame Shift Mutation
- Frame Shift Mutations
- Mutation, Frame Shift
- Mutations, Frame Shift
- Mutation, Frameshift
Out-of-Frame Insertion- Out-of-Frame Insertion
- Insertion, Out-of-Frame
- Insertions, Out-of-Frame
- Out of Frame Insertion
- Out-of-Frame Insertions
Out-of-Frame Deletion- Out-of-Frame Deletion
- Deletion, Out-of-Frame
- Deletions, Out-of-Frame
- Out of Frame Deletion
- Out-of-Frame Deletions
|
Below are MeSH descriptors whose meaning is more general than "Frameshift Mutation".
Below are MeSH descriptors whose meaning is more specific than "Frameshift Mutation".
This graph shows the total number of publications written about "Frameshift Mutation" by people in this website by year, and whether "Frameshift Mutation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Frameshift Mutation" by people in Profiles.
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Bedoukian EC, Rentas S, Skraban C, Shao Q, Treat J, Laird DW, Sullivan KE. Palmoplantar keratoderma with deafness phenotypic variability in a patient with an inherited GJB2 frameshift variant and novel missense variant. Mol Genet Genomic Med. 2021 02; 9(2):e1574.
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Yamashita-Kawanishi N, Ito S, Ishiyama D, Chambers JK, Uchida K, Kasuya F, Haga T. Characterization of Bovine papillomavirus 28 (BPV28) and a novel genotype BPV29 associated with vulval papillomas in cattle. Vet Microbiol. 2020 Nov; 250:108879.
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Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM. A potential screening tool for IPEX syndrome. Pediatr Dev Pathol. 2007 Mar-Apr; 10(2):98-105.
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Kanaan Y, Kpenu E, Utley K, Adams-Campbell L, Dunston GM, Brody LC, Broome C. Inherited BRCA2 mutations in African Americans with breast and/or ovarian cancer: a study of familial and early onset cases. Hum Genet. 2003 Oct; 113(5):452-60.
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Flores-Rozas H, Kolodner RD. The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12404-9.
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Sunter G, Hartitz MD, Hormuzdi SG, Brough CL, Bisaro DM. Genetic analysis of tomato golden mosaic virus: ORF AL2 is required for coat protein accumulation while ORF AL3 is necessary for efficient DNA replication. Virology. 1990 Nov; 179(1):69-77.