RecQ Helicases

"RecQ Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of structurally-related DNA helicases that play an essential role in the maintenance of genome integrity. RecQ helicases were originally discovered in E COLI and are highly conserved across both prokaryotic and eukaryotic organisms. Genetic mutations that result in loss of RecQ helicase activity gives rise to disorders that are associated with CANCER predisposition and premature aging.

Descriptor ID	D053484
MeSH Number(s)	D08.811.277.040.025.159.249 D08.811.399.340.249
Concept/Terms	RecQ Helicases RecQ Helicases Helicases, RecQ RecQ Protein RecQ Family of DNA Helicases RecQL Helicase RecQL Helicase Helicase, RecQL RECQL1 Helicase Helicase, RECQL1 DNA Helicase RecQL DNA-Dependent ATPase Q1 DNA Dependent ATPase Q1 ATP-Dependent DNA Helicase Q1 ATP Dependent DNA Helicase Q1 DNA Helicase Q1 RecQ4 Helicase RecQ4 Helicase RTS Helicase Helicase, RTS RecQL4 Helicase Helicase, RecQL4 ATP-Dependent DNA Helicase Q4 ATP Dependent DNA Helicase Q4 DNA Helicase RecQL4 RecQ5 Helicase RecQ5 Helicase Helicase, RecQ5 RecQ5L Helicase Helicase, RecQ5L ATP-Dependent DNA Helicase Q5 ATP Dependent DNA Helicase Q5 RecQ2 Helicase RecQ2 Helicase Helicase, RecQ2 RecQL3 Helicase Helicase, RecQL3 DNA Helicase, RecQ-like type 2 DNA Helicase, RecQ like type 2 RecQ3 Helicase RecQ3 Helicase Helicase, RecQ3 RecQL2 Helicase Helicase, RecQL2

Below are MeSH descriptors whose meaning is more general than "RecQ Helicases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
DNA Helicases [D08.811.277.040.025.159]
RecQ Helicases [D08.811.277.040.025.159.249]
Isomerases [D08.811.399]
DNA Helicases [D08.811.399.340]
RecQ Helicases [D08.811.399.340.249]

Below are MeSH descriptors whose meaning is related to "RecQ Helicases".

Below are MeSH descriptors whose meaning is more specific than "RecQ Helicases".

RecQ Helicases
Werner Syndrome Helicase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "RecQ Helicases" by people in this website by year, and whether "RecQ Helicases" was a major or minor topic of these publications.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 4 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	3	3
2004	0	1	1
2005	0	4	4
2006	1	1	2
2007	1	0	1
2008	2	0	2
2011	2	0	2
2012	1	0	1
2013	2	0	2
2014	2	0	2
2015	1	0	1
2016	3	0	3
2017	1	0	1
2019	1	0	1
2020	2	0	2
2021	1	0	1
2022	2	0	2
2023	0	1	1

Below are the most recent publications written about "RecQ Helicases" by people in Profiles.

Lashen A, Al-Kawaz A, Jeyapalan JN, Alqahtani S, Shoqafi A, Algethami M, Toss M, Green AR, Mongan NP, Sharma S, Akbari MR, Rakha EA, Madhusudan S. Immune infiltration, aggressive pathology, and poor survival outcomes in RECQL helicase deficient breast cancers. Neoplasia. 2024 01; 47:100957.

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Debnath S, Lu X, Sharma S. Transcriptional regulation by a RecQ helicase. Methods Enzymol. 2022; 673:227-249.

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Debnath S, Lu X, Lal A, Sharma S. Genome-wide investigations on regulatory functions of RECQ1 helicase. Methods. 2022 08; 204:263-268.

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Lu X, Redon CE, Tang W, Parvathaneni S, Bokhari B, Debnath S, Li XL, Muys BR, Song Y, Pongor LS, Sheikh O, Green AR, Madhusudan S, Lal A, Ambs S, Khan J, Aladjem MI, Sharma S. Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells. Mol Cell Biol. 2021 03 24; 41(4).

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Bononi A, Goto K, Ak G, Yoshikawa Y, Emi M, Pastorino S, Carparelli L, Ferro A, Nasu M, Kim JH, Suarez JS, Xu R, Tanji M, Takinishi Y, Minaai M, Novelli F, Pagano I, Gaudino G, Pass HI, Groden J, Grzymski JJ, Metintas M, Akarsu M, Morrow B, Hassan R, Yang H, Carbone M. Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma. Proc Natl Acad Sci U S A. 2020 12 29; 117(52):33466-33473.

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Debnath S, Sharma S. RECQ1 Helicase in Genomic Stability and Cancer. Genes (Basel). 2020 06 05; 11(6).

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Parvathaneni S, Sharma S. The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine. J Biol Chem. 2019 10 18; 294(42):15330-15345.

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Woodrick J, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatkar P, Erkizan HV, Sami F, Su Y, Sch?rer OD, Sharma S, Roy R. A new sub-pathway of long-patch base excision repair involving 5' gap formation. EMBO J. 2017 06 01; 36(11):1605-1622.

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Arora A, Parvathaneni S, Aleskandarany MA, Agarwal D, Ali R, Abdel-Fatah T, Green AR, Ball GR, Rakha EA, Ellis IO, Sharma S, Madhusudan S. Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers. Mol Cancer Ther. 2017 01; 16(1):239-250.

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Sami F, Gary RK, Fang Y, Sharma S. Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain. Mutat Res. 2016 08; 790:8-18.

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