"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
| Descriptor ID |
D045585
|
| MeSH Number(s) |
D08.811.277.352.355.325.350
|
| Concept/Terms |
Flap Endonuclease-1- Flap Endonuclease-1
- Endonuclease-1, Flap
- Flap Endonuclease 1
- RTH-1 Nuclease
- Nuclease, RTH-1
- RTH 1 Nuclease
- RAD2 Homolog-1 Nuclease
- RAD2 Homolog 1 Nuclease
- FEN-1
- Fen1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Flap Endonucleases".
Below are MeSH descriptors whose meaning is more specific than "Flap Endonucleases".
This graph shows the total number of publications written about "Flap Endonucleases" by people in this website by year, and whether "Flap Endonucleases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 2 | 1 | 3 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Flap Endonucleases" by people in Profiles.
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Sami F, Lu X, Parvathaneni S, Roy R, Gary RK, Sharma S. RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin. Biochem J. 2015 Jun 01; 468(2):227-44.
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Entezam A, Lokanga AR, Le W, Hoffman G, Usdin K. Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse model. Hum Mutat. 2010 May; 31(5):611-6.
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Sharma S, Sommers JA, Brosh RM. Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases. Protein Pept Lett. 2008; 15(1):89-102.
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Sharma S, Sommers JA, Gary RK, Friedrich-Heineken E, H?bscher U, Brosh RM. The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res. 2005; 33(21):6769-81.
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Sharma S, Sommers JA, Brosh RM. In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet. 2004 Oct 01; 13(19):2247-61.
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Sharma S, Sommers JA, Wu L, Bohr VA, Hickson ID, Brosh RM. Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem. 2004 Mar 12; 279(11):9847-56.
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Sharma S, Otterlei M, Sommers JA, Driscoll HC, Dianov GL, Kao HI, Bambara RA, Brosh RM. WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell. 2004 Feb; 15(2):734-50.
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Sharma S, Sommers JA, Driscoll HC, Uzdilla L, Wilson TM, Brosh RM. The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem. 2003 Jun 27; 278(26):23487-96.