Receptors, Notch

"Receptors, Notch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.

Descriptor ID	D051880
MeSH Number(s)	D12.776.543.750.725 D12.776.930.770
Concept/Terms	Receptors, Notch Receptors, Notch Notch Proteins Notch Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, Notch".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Notch [D12.776.543.750.725]
Transcription Factors [D12.776.930]
Receptors, Notch [D12.776.930.770]

Below are MeSH descriptors whose meaning is related to "Receptors, Notch".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Notch".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Notch" by people in this website by year, and whether "Receptors, Notch" was a major or minor topic of these publications.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 4 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	1	1	2
2007	0	1	1
2009	1	0	1
2011	1	1	2
2012	0	1	1
2013	3	0	3
2014	1	2	3
2015	1	2	3
2016	1	0	1
2017	2	0	2
2018	1	0	1
2019	0	2	2
2020	1	1	2
2021	3	1	4
2022	0	1	1
2023	0	1	1
2025	1	0	1

Below are the most recent publications written about "Receptors, Notch" by people in Profiles.

Sidhu RS, Guo S, Wang G, Liu M. Role of Notch and its oncogenic signaling crosstalk in glioma and glioma stem cells. Gene. 2025 Oct 15; 969:149761.

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Roy SD, Nagarajan S, Jalal MS, Basar MA, Duttaroy A. New mutant alleles for Spargel/dPGC-1 highlights the function of Spargel RRM domain in oogenesis and expands the role of Spargel in embryogenesis and intracellular transport. G3 (Bethesda). 2023 08 30; 13(9).

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P?rez E, Venkatanarayan A, Lundell MJ. Hunchback prevents notch-induced apoptosis in the serotonergic lineage of Drosophila Melanogaster. Dev Biol. 2022 06; 486:109-120.

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Chen X, Emerson MM. Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states. Sci Rep. 2021 07 15; 11(1):14525.

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Guntur AR, Venkatanarayan A, Gangula S, Lundell MJ. Zfh-2 facilitates Notch-induced apoptosis in the CNS and appendages of Drosophila melanogaster. Dev Biol. 2021 07; 475:65-79.

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Shi M, Ren S, Chen H, Li J, Huang C, Li Y, Han Y, Li Y, Sun Z, Chen X, Xiong Z. Alcohol drinking inhibits NOTCH-PAX9 signaling in esophageal squamous epithelial cells. J Pathol. 2021 04; 253(4):384-395.

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Li Y, Li Y, Chen X. NOTCH and Esophageal Squamous Cell Carcinoma. Adv Exp Med Biol. 2021; 1287:59-68.

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Dutta P, Nath S, Li J, Li WX. Drosophila SERTAD domain protein Taranis is required in somatic cells for maintenance of male germline stem cells. Dev Dyn. 2021 02; 250(2):237-248.

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Goruganthu MUL, Shanker A, Dikov MM, Carbone DP. Specific Targeting of Notch Ligand-Receptor Interactions to Modulate Immune Responses: A Review of Clinical and Preclinical Findings. Front Immunol. 2020; 11:1958.

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Tchekneva EE, Goruganthu MUL, Uzhachenko RV, Thomas PL, Antonucci A, Chekneva I, Koenig M, Piao L, Akhter A, de Aquino MTP, Ranganathan P, Long N, Magliery T, Valujskikh A, Evans JV, Arasada RR, Massion PP, Carbone DP, Shanker A, Dikov MM. Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T?cell immunity. J Immunother Cancer. 2019 04 02; 7(1):95.

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