NF-E2-Related Factor 2

"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.

Descriptor ID	D051267
MeSH Number(s)	D12.776.260.108.737 D12.776.930.127.737
Concept/Terms	NF-E2-Related Factor 2 NF-E2-Related Factor 2 NF E2 Related Factor 2 Nuclear Factor E2-Related Factor 2 Nuclear Factor E2 Related Factor 2 Nfe2l2 Protein Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein

Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
NF-E2-Related Factor 2 [D12.776.260.108.737]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
NF-E2-Related Factor 2 [D12.776.930.127.737]

Below are MeSH descriptors whose meaning is related to "NF-E2-Related Factor 2".

Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.

Bar chart showing 61 publications over 18 distinct years, with a maximum of 9 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2008	3	0	3
2009	1	0	1
2010	3	0	3
2011	3	1	4
2012	2	0	2
2013	3	1	4
2014	1	2	3
2015	4	0	4
2016	2	0	2
2017	1	0	1
2018	5	1	6
2019	3	1	4
2020	6	3	9
2021	2	4	6
2022	0	4	4
2023	0	3	3
2024	1	0	1

Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.

Sampath C, Chukkapalli SS, Raju AV, Alluri LSC, Srisai D, Gangula PR. Cinnamaldehyde Protects against P. gingivalis Induced Intestinal Epithelial Barrier Dysfunction in IEC-6 Cells via the PI3K/Akt-Mediated NO/Nrf2 Signaling Pathway. Int J Mol Sci. 2024 Apr 26; 25(9).

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Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman B, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V, Li Y, Weissman B, Yuan H, Williams KP, Ben Major M, Chen X. Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia. Redox Biol. 2023 11; 67:102901.

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Barber K, Mendonca P, Evans JA, Soliman KFA. Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells. Int J Mol Sci. 2023 Jun 29; 24(13).

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Baranova A, Cao H, Teng S, Su KP, Zhang F. Shared genetics and causal associations between COVID-19 and multiple sclerosis. J Med Virol. 2023 01; 95(1):e28431.

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Adinew GM, Messeha SS, Taka E, Badisa RB, Soliman KFA. Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells. Nutrients. 2022 Nov 13; 14(22).

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Metibemu DS, Ogungbe IV. Carotenoids in Drug Discovery and Medicine: Pathways and Molecular Targets Implicated in Human Diseases. Molecules. 2022 Sep 15; 27(18).

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Adinew G, Messeha SS, Badisa R, Taka E, Soliman KFA. Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD-L1 in MDA-MB-231 Triple-Negative Breast Cancer Cells. FASEB J. 2022 05; 36 Suppl 1.

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Sampath C, Raju AV, Freeman ML, Srinivasan S, Gangula PR. Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function. Am J Physiol Gastrointest Liver Physiol. 2022 03 01; 322(3):G368-G382.

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Awoyomi OV, Adeoye YD, Oyagbemi AA, Ajibade TO, Asenuga ER, Gbadamosi IT, Ogunpolu BS, Falayi OO, Hassan FO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Oguntibeju OO, Yakubu MA. Luteolin mitigates potassium dichromate-induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim-1/Nrf2 signaling pathways. Environ Toxicol. 2021 Nov; 36(11):2146-2160.

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Thakur V, Alcoreza N, Delgado M, Joddar B, Chattopadhyay M. Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats. Biomolecules. 2021 04 13; 11(4).

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