"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
| Descriptor ID |
D009569
|
| MeSH Number(s) |
D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
|
| Concept/Terms |
Nitric Oxide- Nitric Oxide
- Oxide, Nitric
- Nitrogen Monoxide
- Monoxide, Nitrogen
- Nitric Oxide, Endothelium-Derived
- Endothelium-Derived Nitric Oxide
- Nitric Oxide, Endothelium Derived
- Endogenous Nitrate Vasodilator
- Nitrate Vasodilator, Endogenous
- Vasodilator, Endogenous Nitrate
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
|
Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".
Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".
This graph shows the total number of publications written about "Nitric Oxide" by people in this website by year, and whether "Nitric Oxide" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 3 | 0 | 3 |
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 4 | 6 |
| 2001 | 0 | 5 | 5 |
| 2002 | 11 | 8 | 19 |
| 2003 | 8 | 8 | 16 |
| 2004 | 9 | 8 | 17 |
| 2005 | 10 | 8 | 18 |
| 2006 | 8 | 6 | 14 |
| 2007 | 8 | 6 | 14 |
| 2008 | 5 | 5 | 10 |
| 2009 | 7 | 4 | 11 |
| 2010 | 9 | 12 | 21 |
| 2011 | 7 | 5 | 12 |
| 2012 | 5 | 7 | 12 |
| 2013 | 3 | 9 | 12 |
| 2014 | 1 | 10 | 11 |
| 2015 | 7 | 9 | 16 |
| 2016 | 3 | 7 | 10 |
| 2017 | 3 | 3 | 6 |
| 2018 | 2 | 9 | 11 |
| 2019 | 5 | 0 | 5 |
| 2020 | 7 | 4 | 11 |
| 2021 | 5 | 5 | 10 |
| 2022 | 1 | 7 | 8 |
| 2023 | 4 | 8 | 12 |
| 2024 | 4 | 1 | 5 |
| 2025 | 3 | 3 | 6 |
To return to the timeline,
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Below are the most recent publications written about "Nitric Oxide" by people in Profiles.
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Baskaran P, Aldhaeefi M, Asaadi A, Jones M, King E, Rungkitwattanakul D, Wingate L. Empagliflozin and hydralazine-isosorbide dinitrate combination therapy improves outcomes in Black patients with heart failure. Int J Clin Pharmacol Ther. 2025 Nov; 63(11):553-556.
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O'Connor JL, Fountos DM, Firouzan B, Azizi F, Ghasemi R, Kashfi K. The role of gasotransmitters in Parkinson's disease: Interplay of nitric oxide, carbon monoxide, and hydrogen sulfide. Neurotherapeutics. 2025 Oct; 22(6):e00710.
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Armina-Rodriguez A, Vald?s Fernandez BN, Ocasio-Malav? C, Cantres Rosario YM, Carrasquillo Carri?n K, Mel?ndez LM, Roche Lima A, Tosado Rodriguez EL, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-?B, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. Int J Mol Sci. 2025 Jul 18; 26(14).
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Jeddi S, Kashfi K, Ghasemi A. The potential role of nitrate, a nitric oxide donor, in the prevention and treatment of diabetic osteoporosis. Front Endocrinol (Lausanne). 2025; 16:1480838.
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Farahani A, Farahani A, Kashfi K, Ghasemi A. Inhibition of hepatic gluconeogenesis in type 2 diabetes by metformin: complementary role of nitric oxide. Med Gas Res. 2025 Dec 01; 15(4):507-519.
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Ferrini MG, Abraham A, Mill?n R, Graciano L, Eleswarapu SV, Rajfer J. Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. PLoS One. 2025; 20(2):e0316798.
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Ghasemi A, Jeddi S, Kashfi K. Brain glucose metabolism: Role of nitric oxide. Biochem Pharmacol. 2025 02; 232:116728.
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Chattopadhyay M, Nath N, Kodela R, Metkar S, Soyemi SA, Kashfi K. NOSH-aspirin (NBS-1120) inhibits estrogen receptor-negative breast cancer in?vitro and in?vivo by modulating redox-sensitive signaling pathways. J Pharmacol Exp Ther. 2025 Jan; 392(1):100019.
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Dos Reis RA, Sarkar I, Rodrigues MG, Matson JB, Seabra AB, Kashfi K. NO- and H2S- releasing nanomaterials: A crosstalk signaling pathway in cancer. Nitric Oxide. 2024 Oct 01; 151:17-30.
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Bahadoran Z, Mirmiran P, Hosseinpanah F, Kashfi K, Ghasemi A. Nitric oxide-based treatments improve wound healing associated with diabetes mellitus. Med Gas Res. 2025 Mar 01; 15(1):23-35.