Reactive Oxygen Species

"Reactive Oxygen Species" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.

Descriptor ID	D017382
MeSH Number(s)	D01.339.431 D01.650.775
Concept/Terms	Reactive Oxygen Species Reactive Oxygen Species Oxygen Species, Reactive Active Oxygen Oxygen, Active Oxygen Radicals Pro-Oxidants Pro Oxidants

Below are MeSH descriptors whose meaning is more general than "Reactive Oxygen Species".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Free Radicals [D01.339]
Reactive Oxygen Species [D01.339.431]
Oxygen Compounds [D01.650]
Reactive Oxygen Species [D01.650.775]

Below are MeSH descriptors whose meaning is related to "Reactive Oxygen Species".

Below are MeSH descriptors whose meaning is more specific than "Reactive Oxygen Species".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Reactive Oxygen Species" by people in this website by year, and whether "Reactive Oxygen Species" was a major or minor topic of these publications.

Bar chart showing 374 publications over 28 distinct years, with a maximum of 26 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	3	3
1999	0	2	2
2000	1	4	5
2001	2	2	4
2002	3	8	11
2003	2	5	7
2004	4	4	8
2005	1	6	7
2006	5	6	11
2007	2	17	19
2008	5	9	14
2009	1	14	15
2010	4	21	25
2011	4	14	18
2012	5	11	16
2013	3	13	16
2014	3	15	18
2015	3	18	21
2016	6	16	22
2017	3	14	17
2018	4	10	14
2019	0	17	17
2020	3	10	13
2021	3	7	10
2022	2	11	13
2023	0	12	12
2024	7	19	26
2025	0	10	10

Below are the most recent publications written about "Reactive Oxygen Species" by people in Profiles.

Katti P, Prasad P, Masenga SK, Venkhatesh P, Vue Z, Marshall AG, Rodriguez B, Le H, Garza-Lopez E, Murphy A, Jenkins B, Kadam A, Shao J, Crabtree A, Martin P, Evans C, Phillips MA, Hubert D, Wandira N, Ochayi OM, Tomar D, Williams CR, Gaddy J, Tomeau B, Bell L, Gillyard T, Hamilton M, Sharma V, Khan MM, Zaganjor E, Ajijola OA, Scudese E, Miller Fleming TW, Kinder A, Dash C, Quintana AM, Mobley BC, Berry JD, Jadiya P, Dai DF, Kirabo A, Kovtun O, Schafer JC, Schaffer S, Pereira RO, Murray DD, Gamble-George J, McReynolds MR, Hinton A. The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney. Aging Cell. 2026 05; 25(5):e70534.

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Gutierrez DA, Robles-Escajeda E, Lopez-Saenz JA, Kirken RA, Borrego EA, Betancourt AP, Nair S, Roy S, Varela-Ramirez A, Aguilera RJ. Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways. Oncol Res. 2026; 34(4):14.

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Rasafar N, Sanchez-Michael LA, Torres A, Andujo LA, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Noveron JC. Novel anticancer alkyl pyridinium derivative exhibits antiproliferative activity via G0/G1 cell cycle arrest and apoptosis activation in triple-negative breast cancer cells. Bioorg Med Chem. 2026 Jun; 137:118638.

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Castedo N, Alfonso A, Alvari?o R, Pech-Puch D, Ageitos L, Rodr?guez J, Vieytes MR, Jim?nez C, Botana LM. Neuroprotective Effects of Furanoditerpenes from Spongia (Spongia) Tubulifera through Cyclophilin D Modulation against Ischemia/Reperfusion Injury in BV2 Microglial Cells. ACS Chem Neurosci. 2026 Apr 01; 17(7):1332-1344.

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Tan AMZ, Celik C, Lee SYT, Veleba M, Manzano CS, Abdul RMK, Thibault G, Kline KA. Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing. Sci Adv. 2026 Jan 16; 12(3):eaeb5297.

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Sayadujjhara M, Yalcin YS, Ghann W, Uddin J, Sitther V. Strain-Specific Impact of Titanium Dioxide Nanoparticles on Fremyella Diplosiphon Physiological and Metabolic Responses. Curr Microbiol. 2025 Dec 01; 83(1):53.

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Dhungana G, Sampath C, Sharma V, Korolkova O, Gangula PR. Role of Nitric Oxide and Nrf2 to Counteract Vascular Endothelial Dysfunction Induced by Periodontal Pathogens Using HUVECs. Cells. 2025 Nov 12; 14(22).

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Sadikaj D, Fekri A, Bautista I, Davis N, Agha Alkla T, Mirza MMH, Wang J, Stallworth P, Hudson-Smith N, Bandosz TJ, Yu X, Greenbaum S, Li W. Importance of S-Doped Porous Carbon Acidity and Visible Light Photoactivity for Its Antibacterial Activity. ACS Appl Mater Interfaces. 2025 Nov 26; 17(47):64106-64117.

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Lazarte JMS, Ofosu-Asante K, Tilghman SL, Lamango NS. PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion. Oncotarget. 2025 Jul 29; 16:621-641.

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Pal A, Bawali P, Brahma A, Rana SR, Mohapatra R, Chakraborty D, Poirah I, Samal S, Banerjee S, Smoot DT, Ashktorab H, Bhattacharyya A. RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells. J Cell Sci. 2025 Jul 15; 138(14).

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