"Receptors, Death Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
| Descriptor ID |
D053218
|
| MeSH Number(s) |
D12.776.543.750.690
|
| Concept/Terms |
Receptors, Death Domain- Receptors, Death Domain
- Death Receptors
- Death Domain Receptors
- Receptors, Death Domain Family
- Receptors, DR Family
- DR Family Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Death Domain".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Death Domain".
This graph shows the total number of publications written about "Receptors, Death Domain" by people in this website by year, and whether "Receptors, Death Domain" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Death Domain" by people in Profiles.
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Park SJ, Kumar M, Kwon HI, Seong RK, Han K, Song JM, Kim CJ, Choi YK, Shin OS. Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice. Sci Rep. 2015 Nov 18; 5:16512.
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Shen Y, Herde R, Doxey BW, Xu C, Gray PD, Kuwada SK. Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model. Int J Cancer. 2012 Apr 01; 130(7):1494-503.
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Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010 Mar; 30(6):1341-56.