Receptors, TNF-Related Apoptosis-Inducing Ligand

"Receptors, TNF-Related Apoptosis-Inducing Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved DEATH DOMAINS that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Descriptor ID	D053220
MeSH Number(s)	D12.776.543.750.690.600 D12.776.543.750.705.852.760.396
Concept/Terms	Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, TNF Related Apoptosis Inducing Ligand Tumor Necrosis Factor Receptor Superfamily, Member 10 TRAIL Receptors Receptors, TRAIL Receptors, Tumor Necrosis Factor, Member 10 TNF-Related Apoptosis-Inducing Ligand Receptors TNF Related Apoptosis Inducing Ligand Receptors Receptors, Tumor Necrosis Factor, Member 10d Receptors, Tumor Necrosis Factor, Member 10d Decoy Receptor 2, Tumor Necrosis Factor Receptor, TRAIL-4 Receptor, TRAIL 4 TRAIL-4 Receptor DCR2 Receptor Receptor, DCR2 CD264 Antigen Antigen, CD264 TRAIL Receptor 4 Receptor 4, TRAIL Receptors, Tumor Necrosis Factor, Member 10a Receptors, Tumor Necrosis Factor, Member 10a Tumor Necrosis Factor Receptor Superfamily, Member 10a APO2 Receptor Receptor, APO2 Receptor, TRAIL-1 Receptor, TRAIL 1 TRAIL-1 Receptor TRAIL Receptor 1 DR4 Receptor Receptor, DR4 CD261 Antigen Antigen, CD261 Death Receptor-4 Death Receptor 4 Receptor-4, Death Receptors, Tumor Necrosis Factor, Member 10b Receptors, Tumor Necrosis Factor, Member 10b TRAIL Receptor 2 Receptor, TRAIL-2 Receptor, TRAIL 2 TRAIL-2 Receptor DR5 Receptor Receptor, DR5 Tumor Necrosis Factor Receptor Superfamily, Member 10b TNF-Related Apoptosis-Inducing Ligand Receptor 2 TNF Related Apoptosis Inducing Ligand Receptor 2 CD262 Antigen Antigen, CD262 Death Receptor-5 Death Receptor 5

Below are MeSH descriptors whose meaning is more general than "Receptors, TNF-Related Apoptosis-Inducing Ligand".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Death Domain [D12.776.543.750.690]
Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.690.600]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.705.852.760.396]

Below are MeSH descriptors whose meaning is related to "Receptors, TNF-Related Apoptosis-Inducing Ligand".

Below are MeSH descriptors whose meaning is more specific than "Receptors, TNF-Related Apoptosis-Inducing Ligand".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in this website by year, and whether "Receptors, TNF-Related Apoptosis-Inducing Ligand" was a major or minor topic of these publications.

Bar chart showing 9 publications over 5 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	0	1
2008	1	1	2
2010	2	1	3
2012	0	2	2
2021	1	0	1

Below are the most recent publications written about "Receptors, TNF-Related Apoptosis-Inducing Ligand" by people in Profiles.

Shivange G, Mondal T, Lyerly E, Bhatnagar S, Landen CN, Reddy S, Kim J, Doan B, Riddle P, Tushir-Singh J. A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors. Cell Rep. 2021 11 02; 37(5):109953.

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Gopalan A, Yu W, Jiang Q, Jang Y, Sanders BG, Kline K. Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. Mol Nutr Food Res. 2012 Dec; 56(12):1803-11.

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Xiong A, Yu W, Tiwary R, Sanders BG, Kline K. Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells. Mol Nutr Food Res. 2012 Jun; 56(6):923-34.

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Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K. Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One. 2010 Jul 29; 5(7):e11865.

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Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. Clin Cancer Res. 2010 Apr 15; 16(8):2320-32.

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Park SK, Sanders BG, Kline K. Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling. Breast Cancer Res Treat. 2010 Nov; 124(2):361-75.

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Shanker A, Brooks AD, Tristan CA, Wine JW, Elliott PJ, Yagita H, Takeda K, Smyth MJ, Murphy WJ, Sayers TJ. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J Natl Cancer Inst. 2008 May 07; 100(9):649-62.

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Hallett WH, Ames E, Motarjemi M, Barao I, Shanker A, Tamang DL, Sayers TJ, Hudig D, Murphy WJ. Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition. J Immunol. 2008 Jan 01; 180(1):163-70.

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Yu W, Park SK, Jia L, Tiwary R, Scott WW, Li J, Wang P, Simmons-Menchaca M, Sanders BG, Kline K. RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Lett. 2008 Feb 08; 259(2):165-76.

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