Receptors, Tumor Necrosis Factor, Type I

"Receptors, Tumor Necrosis Factor, Type I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Descriptor ID	D047888
MeSH Number(s)	D12.776.543.750.690.750 D12.776.543.750.705.852.760.597
Concept/Terms	Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Member 1A TNFR p60 TNFR-I Tumor Necrosis Factor Receptor Type I TNFR1 Tumor Necrosis Factor Receptor 1A TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) Tumor Necrosis Factor Receptor Type 1 Antigens, CD120a CD120a Antigens TNFRSF1A Receptor Receptor, TNFRSF1A Tumor Necrosis Factor Receptor Superfamily, Member 1A CD 120a Antigen 120a Antigen, CD Antigen, CD 120a CD120a Antigen Antigen, CD120a

Below are MeSH descriptors whose meaning is more general than "Receptors, Tumor Necrosis Factor, Type I".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Death Domain [D12.776.543.750.690]
Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.690.750]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.705.852.760.597]

Below are MeSH descriptors whose meaning is related to "Receptors, Tumor Necrosis Factor, Type I".

Below are MeSH descriptors whose meaning is more specific than "Receptors, Tumor Necrosis Factor, Type I".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in this website by year, and whether "Receptors, Tumor Necrosis Factor, Type I" was a major or minor topic of these publications.

Bar chart showing 18 publications over 12 distinct years, with a maximum of 4 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	3	3
2004	1	3	4
2005	1	0	1
2006	1	1	2
2007	0	1	1
2010	0	1	1
2013	0	1	1
2014	0	1	1
2016	1	0	1
2017	0	1	1
2022	0	1	1
2025	1	0	1

Below are the most recent publications written about "Receptors, Tumor Necrosis Factor, Type I" by people in Profiles.

Cabrera-Fuentes HA, Ruiz-Meana M, Barreto G, Serebruany VL, S?nchez-Vega JT, P?rez-Campos E, Kostin S, B?ning A, Jarqu?n Gonz?lez EE, Al-Suhaimi EA, Rodriguez-Montesinos J, Inserte J, Pedretti S, Yap J, Irei J, Sedding DG, Lecour S, Liehn EA, Garcia-Dorado D, Hausenloy DJ, Boisvert WA, Preissner KT. Extracellular RNA drives TNF-a/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1. Pharmacol Res. 2025 Nov; 221:107944.

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Chakraborty R, Maltz MR, Del Castillo D, Tandel PN, Messih N, Anguiano M, Lo DD. Selective Targeting of Tumour Necrosis Factor Receptor 1 Induces Stable Protection from Crohn's-Like Ileitis in TNF?ARE Mice. J Crohns Colitis. 2022 Jul 14; 16(6):978-991.

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Parnell EA, Walch EM, Lo DD. Inducible Colonic M Cells Are Dependent on TNFR2 but Not Lt?r, Identifying Distinct Signalling Requirements for Constitutive Versus Inducible M Cells. J Crohns Colitis. 2017 Jun 01; 11(6):751-760.

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Chang YW, Assari S, Prossin AR, Stertz L, McInnis MG, Evans SJ. Bipolar disorder moderates associations between linoleic acid and markers of inflammation. J Psychiatr Res. 2017 02; 85:29-36.

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Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. TNF-TNFR2/p75 signaling inhibits early and increases delayed nontargeted effects in bone marrow-derived endothelial progenitor cells. J Biol Chem. 2014 May 16; 289(20):14178-93.

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Duhart JM, Leone MJ, Paladino N, Evans JA, Castanon-Cervantes O, Davidson AJ, Golombek DA. Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-a. J Immunol. 2013 Nov 01; 191(9):4656-64.

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Son DS, Terranova PF, Roby KF. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010 Jul; 151(7):3407-19.

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Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007 Nov; 39(11):1397-402.

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Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC. Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. Exp Neurol. 2006 Dec; 202(2):410-20.

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Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, Franzoso G, Carbone M. TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10397-10402.

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