Receptor, erbB-3

"Receptor, erbB-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.

Descriptor ID	D020893
MeSH Number(s)	D08.811.913.696.620.682.725.400.009.500 D12.776.543.750.630.009.500 D12.776.543.750.750.400.074.500 D12.776.624.664.700.790 D23.101.140.721
Concept/Terms	Receptor, ErbB-3 Receptor, ErbB-3 ErbB-3 Receptor Receptor, ErbB 3 Proto-Oncogene Protein erbB-3 Proto Oncogene Protein erbB 3 erbB-3, Proto-Oncogene Protein erbB-3 Protein erbB 3 Protein HER-3 Proto-Oncogene Protein HER 3 Proto Oncogene Protein Proto-Oncogene Protein, HER-3 Tyrosine Kinase-type Cell Surface Receptor HER3 Tyrosine Kinase type Cell Surface Receptor HER3 Proto-Oncogene Proteins erbB-3 Proto Oncogene Proteins erbB 3 erbB-3, Proto-Oncogene Proteins Proto-oncogene-like Protein c-ErbB-2 Protein c-ErbB-2, Proto-oncogene-like Proto oncogene like Protein c ErbB 2 c-ErbB-2, Proto-oncogene-like Protein c-erbB-3 Protein c erbB 3 Protein Proto-Oncogene Protein c-erbB-3 Proto Oncogene Protein c erbB 3 c-erbB-3, Proto-Oncogene Protein

Below are MeSH descriptors whose meaning is more general than "Receptor, erbB-3".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
ErbB Receptors [D08.811.913.696.620.682.725.400.009]
Receptor, ErbB-3 [D08.811.913.696.620.682.725.400.009.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
ErbB Receptors [D12.776.543.750.630.009]
Receptor, ErbB-3 [D12.776.543.750.630.009.500]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
ErbB Receptors [D12.776.543.750.750.400.074]
Receptor, ErbB-3 [D12.776.543.750.750.400.074.500]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Receptor, ErbB-3 [D12.776.624.664.700.790]
Biological Factors [D23]
Biomarkers [D23.101]
Biomarkers, Tumor [D23.101.140]
Receptor, ErbB-3 [D23.101.140.721]

Below are MeSH descriptors whose meaning is related to "Receptor, erbB-3".

Below are MeSH descriptors whose meaning is more specific than "Receptor, erbB-3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptor, erbB-3" by people in this website by year, and whether "Receptor, erbB-3" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2009 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2007	1	0	1
2009	2	0	2
2010	1	0	1
2011	0	1	1
2013	1	0	1
2014	0	1	1
2016	0	1	1
2017	0	2	2

Below are the most recent publications written about "Receptor, erbB-3" by people in Profiles.

Chowdhury I, Branch A, Mehrabi S, Ford BD, Thompson WE. Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival. Endocrinology. 2017 10 01; 158(10):3647-3660.

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Ma Z, Parris AB, Xiao Z, Howard EW, Kosanke SD, Feng X, Yang X. Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice. J Exp Clin Cancer Res. 2017 01 06; 36(1):6.

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Sheng X, Bowen N, Wang Z. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer. 2016 Mar 18; 15:25.

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Abid SN, Richardson TE, Powell HM, Jaichander P, Chaudhary J, Chapman KM, Hamra FK. A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IX. Biol Reprod. 2014 Feb; 90(2):32.

View in: PubMed
Huang J, Wang S, Lyu H, Cai B, Yang X, Wang J, Liu B. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells. Mol Cancer. 2013 Nov 11; 12(1):134.

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Huang X, Wang S, Lee CK, Yang X, Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2-overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Lett. 2011 Aug 01; 307(1):72-79.

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Huang X, Gao L, Wang S, McManaman JL, Thor AD, Yang X, Esteva FJ, Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. Cancer Res. 2010 Feb 01; 70(3):1204-14.

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Liu B, Ordonez-Ercan D, Fan Z, Huang X, Edgerton SM, Yang X, Thor AD. Estrogenic promotion of ErbB2 tyrosine kinase activity in mammary tumor cells requires activation of ErbB3 signaling. Mol Cancer Res. 2009 Nov; 7(11):1882-92.

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Miller TW, P?rez-Torres M, Narasanna A, Guix M, St?l O, P?rez-Tenorio G, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res. 2009 May 15; 69(10):4192-201.

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Liu B, Ordonez-Ercan D, Fan Z, Edgerton SM, Yang X, Thor AD. Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. Int J Cancer. 2007 May 01; 120(9):1874-82.

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