Proliferating Cell Nuclear Antigen

"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

Descriptor ID	D018809
MeSH Number(s)	D12.776.660.740 D23.050.290.750 D23.101.140.600
Concept/Terms	Proliferating Cell Nuclear Antigen Proliferating Cell Nuclear Antigen PCNA Antigen, Proliferating Cell Nuclear

Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Proliferating Cell Nuclear Antigen [D12.776.660.740]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Nuclear [D23.050.290]
Proliferating Cell Nuclear Antigen [D23.050.290.750]
Biomarkers [D23.101]
Biomarkers, Tumor [D23.101.140]
Proliferating Cell Nuclear Antigen [D23.101.140.600]

Below are MeSH descriptors whose meaning is related to "Proliferating Cell Nuclear Antigen".

Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.

Bar chart showing 34 publications over 22 distinct years, with a maximum of 6 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	1	1	2
1996	1	1	2
1997	0	1	1
1999	0	1	1
2000	1	0	1
2002	1	0	1
2004	1	0	1
2005	1	1	2
2006	0	2	2
2007	0	1	1
2008	0	2	2
2009	0	6	6
2010	0	3	3
2011	1	0	1
2012	0	1	1
2013	1	0	1
2014	0	1	1
2015	1	0	1
2018	1	0	1
2019	1	0	1
2023	0	1	1

Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.

Celada SI, Li G, Celada LJ, Lu W, Kanagasabai T, Feng W, Cao Z, Salsabeel N, Mao N, Brown LK, Mark ZA, Izban MG, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Wang X, Chen Z. Lysosome-dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer. Mol Oncol. 2023 10; 17(10):2126-2146.

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Pradhan S, Kalia I, Roy SS, Singh OP, Adak T, Singh AP, Dhar SK. Molecular characterization and expression profile of an alternate proliferating cell nuclear antigen homolog PbPCNA2 in Plasmodium berghei. IUBMB Life. 2019 09; 71(9):1293-1301.

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Khan F, Ricks-Santi LJ, Zafar R, Kanaan Y, Naab T. Expression of p27 and c-Myc by immunohistochemistry in breast ductal cancers in African American women. Ann Diagn Pathol. 2018 Jun; 34:170-174.

View in: PubMed
Polotskaia A, Xiao G, Reynoso K, Martin C, Qiu WG, Hendrickson RC, Bargonetti J. Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1220-9.

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Brown DI, Lass?gue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. PLoS One. 2014; 9(5):e96657.

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Campbell MJ, Wolf D, Mukhtar RA, Tandon V, Yau C, Au A, Baehner F, van't Veer L, Berry D, Esserman LJ. The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context. PLoS One. 2013; 8(10):e79114.

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Fleming JM, Miller TC, Kidacki M, Ginsburg E, Stuelten CH, Stewart DA, Troester MA, Vonderhaar BK. Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo. Breast Cancer Res. 2012 Jun 25; 14(3):R97.

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Mukhtar RA, Moore AP, Nseyo O, Baehner FL, Au A, Moore DH, Twomey P, Campbell MJ, Esserman LJ. Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity. Breast Cancer Res Treat. 2011 Nov; 130(2):635-44.

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Stemb?rek J, Buchtov? M, Kr?l T, Matalov? E, Lozanoff S, M?ek I. Early morphogenesis of heterodont dentition in minipigs. Eur J Oral Sci. 2010 Dec; 118(6):547-58.

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Sharan C, Halder SK, Thota C, Jaleel T, Nair S, Al-Hendy A. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril. 2011 Jan; 95(1):247-53.

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