Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
| Descriptor ID |
D019860
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| MeSH Number(s) |
D08.811.913.696.620.682.725.800.315 D12.776.624.664.700.128
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| Concept/Terms |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- p56 lck
- Proto-Oncogene Protein c-lck
- Protein c-lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- c-lck, Proto-Oncogene Protein
- Proto-Oncogene Protein lck
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein lck
- lck, Proto-Oncogene Protein
- lck Kinase
- Kinase, lck
- Protein Tyrosine Kinase p56(lck)
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in this website by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.
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Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91.
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Kawamura A, Hindi S, Mihai DM, James L, Aminova O. Binding is not enough: flexibility is needed for photocrosslinking of Lck kinase by benzophenone photoligands. Bioorg Med Chem. 2008 Oct 01; 16(19):8824-9.
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Hindi S, Deng H, James L, Kawamura A. Selective photolabeling of Lck kinase in complex proteome. Bioorg Med Chem Lett. 2006 Nov 01; 16(21):5625-8.
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Stepkowski SM, Erwin-Cohen RA, Behbod F, Wang ME, Qu X, Tejpal N, Nagy ZS, Kahan BD, Kirken RA. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 2002 Jan 15; 99(2):680-9.
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Popik W, Hesselgesser JE, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998 Aug; 72(8):6406-13.
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Adunyah SE, Wheeler BJ, Cooper RS. Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Commun. 1997 Mar 27; 232(3):754-8.
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Popik W, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol. 1996 Nov; 16(11):6532-41.