STAT5 Transcription Factor

"STAT5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.

Descriptor ID	D050799
MeSH Number(s)	D12.644.360.024.342.500 D12.776.157.057.186.500 D12.776.476.024.430.500 D12.776.930.840.500
Concept/Terms	STAT5 Transcription Factor STAT5 Transcription Factor Factor, STAT5 Transcription Transcription Factor, STAT5 STAT5 Protein Signal Transducer and Activator of Transcription 5 STAT5b Transcription Factor STAT5b Transcription Factor Transcription Factor, STAT5b STAT5beta Protein STAT5b Protein Signal Transducer and Activator of Transcription 5B STAT5a Transcription Factor STAT5a Transcription Factor Transcription Factor, STAT5a Mammary Gland Factor Signal Transducer and Activator of Transcription 5A STAT5alpha Protein STAT5a Protein Mammary Gland-Specific Nuclear Factor Mammary Gland Specific Nuclear Factor

Below are MeSH descriptors whose meaning is more general than "STAT5 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
STAT Transcription Factors [D12.644.360.024.342]
STAT5 Transcription Factor [D12.644.360.024.342.500]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
STAT Transcription Factors [D12.776.157.057.186]
STAT5 Transcription Factor [D12.776.157.057.186.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
STAT Transcription Factors [D12.776.476.024.430]
STAT5 Transcription Factor [D12.776.476.024.430.500]
Transcription Factors [D12.776.930]
STAT Transcription Factors [D12.776.930.840]
STAT5 Transcription Factor [D12.776.930.840.500]

Below are MeSH descriptors whose meaning is related to "STAT5 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "STAT5 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "STAT5 Transcription Factor" by people in this website by year, and whether "STAT5 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 41 publications over 23 distinct years, with a maximum of 6 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	2	2
1998	0	2	2
1999	0	1	1
2000	0	2	2
2001	0	3	3
2002	0	2	2
2003	0	2	2
2004	0	1	1
2005	0	1	1
2006	2	0	2
2007	0	1	1
2008	3	3	6
2009	2	0	2
2010	0	1	1
2011	1	0	1
2012	1	0	1
2013	2	2	4
2015	0	1	1
2017	0	1	1
2018	0	1	1
2023	1	0	1
2024	1	1	2

Below are the most recent publications written about "STAT5 Transcription Factor" by people in Profiles.

Williams A, Hossack DJ, Thompson N, Sim YE, Wilson C, Schuch V, Hailstorks T, Chakraborty R, Johnson EL. Elevated levels of exogenous prolactin promote inflammation at the maternal-fetal interface via the JAK2/STAT5B signaling axis. Front Immunol. 2024; 15:1496610.

View in: PubMed
Tsuruta T, Matsumura N, Mizukami K, Goto-Koshino Y, Aoi T, Yamada R, Nagao I, Sakamoto M, Nakagawa T, Fukuoka R, Ohmi A, Chambers JK, Uchida K, Momozawa Y, Tomiyasu H. Investigation of the mutations in the genes involved in Janus kinase/signal transducer and activator of transcription pathway in canine large cell gastrointestinal lymphoma. J Vet Med Sci. 2024 Oct 01; 86(10):1052-1055.

View in: PubMed
Rodriguez G, Martinez GS, Negrete OD, Sun S, Guo W, Xie Y, Li L, Xiao C, Ross JA, Kirken RA. JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation. Int J Mol Sci. 2023 Jul 25; 24(15).

View in: PubMed
Ruiz-Medina BE, Cadena-Medina DA, Esparza E, Arrieta AJ, Kirken RA. Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling. Biochem J. 2018 09 18; 475(18):2907-2923.

View in: PubMed
Pellom ST, Dudimah DF, Thounaojam MC, Uzhachenko RV, Singhal A, Richmond A, Shanker A. Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function. Oncotarget. 2017 Jan 31; 8(5):8604-8621.

View in: PubMed
Ruiz-Medina BE, Ross JA, Kirken RA. Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules. J Biol Chem. 2015 Aug 21; 290(34):20972-20983.

View in: PubMed
Gupta BK, Maher DM, Ebeling MC, Stephenson PD, Puumala SE, Koch MR, Aburatani H, Jaggi M, Chauhan SC. Functions and regulation of MUC13 mucin in colon cancer cells. J Gastroenterol. 2014 Oct; 49(10):1378-91.

View in: PubMed
Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li WX. Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10213-8.

View in: PubMed
Nagy ZS, Ross JA, Rodriguez G, Balint BL, Szeles L, Nagy L, Kirken RA. Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells. PLoS One. 2013; 8(2):e57326.

View in: PubMed
Rodriguez G, Ross JA, Nagy ZS, Kirken RA. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. J Biol Chem. 2013 Mar 08; 288(10):7137-46.

View in: PubMed

People

Explore

Similar Concepts

Top Journals