Serpins

"Serpins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES.

Descriptor ID	D015843
MeSH Number(s)	D12.644.861 D12.776.872 D27.505.519.389.745.800.675
Concept/Terms	Serpins Serpins Serpin Protease Inhibitors Inhibitors, Serpin Protease Protease Inhibitors, Serpin Serpin Peptidase Inhibitors Inhibitors, Serpin Peptidase Peptidase Inhibitors, Serpin Serpin Superfamily Serpin Superfamily Superfamily, Serpin

Below are MeSH descriptors whose meaning is more general than "Serpins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Serpins [D12.644.861]
Proteins [D12.776]
Serpins [D12.776.872]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protease Inhibitors [D27.505.519.389.745]
Serine Proteinase Inhibitors [D27.505.519.389.745.800]
Serpins [D27.505.519.389.745.800.675]

Below are MeSH descriptors whose meaning is related to "Serpins".

Below are MeSH descriptors whose meaning is more specific than "Serpins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Serpins" by people in this website by year, and whether "Serpins" was a major or minor topic of these publications.

Bar chart showing 22 publications over 14 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	2	0	2
2003	3	0	3
2004	0	1	1
2005	1	0	1
2006	1	0	1
2008	1	1	2
2010	1	0	1
2011	1	1	2
2012	3	1	4
2014	1	0	1
2017	1	0	1
2018	0	1	1
2020	1	0	1
2024	1	0	1

Below are the most recent publications written about "Serpins" by people in Profiles.

Wu L, Liu Y, He Q, Ao G, Xu N, He W, Liu X, Huang L, Yu Q, Kanamaru H, Dong S, Zhu S, Yuan Y, Han M, Ling Y, Liu L, Wu C, Zhou Y, Sherchan P, Flores JJ, Tang J, Chen X, He X, Zhang JH. PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2024 Jul 21; 21(1):178.

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Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. 2020 06 03; 106(5):727-742.e6.

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Verdes A, Simpson D, Holford M. Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae). Genome Biol Evol. 2018 01 01; 10(1):249-268.

View in: PubMed
Shii L, Song L, Maurer K, Zhang Z, Sullivan KE. SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs. Mol Immunol. 2017 08; 88:20-31.

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Mu?iz A, Greene WA, Plamper ML, Choi JH, Johnson AJ, Tsin AT, Wang HC. Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle. Invest Ophthalmol Vis Sci. 2014 Jan 09; 55(1):198-209.

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He Q, Ananaba GA, Patrickson J, Pitts S, Yi Y, Yan F, Eko FO, Lyn D, Black CM, Igietseme JU, Thierry-Palmer M. Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice. J Steroid Biochem Mol Biol. 2013 May; 135:7-14.

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Parvathaneni K, Grigsby JG, Betts BS, Tsin AT. Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways. J Ocul Pharmacol Ther. 2013 Feb; 29(1):27-32.

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Jerebtsova M, Kumari N, Obuhkov Y, Nekhai S. Adenoviral E4 gene stimulates secretion of pigmental epithelium derived factor (PEDF) that maintains long-term survival of human glomerulus-derived endothelial cells. Mol Cell Proteomics. 2012 Nov; 11(11):1378-88.

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Neal CL, Henderson V, Smith BN, McKeithen D, Graham T, Vo BT, Odero-Marah VA. Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells. BMC Cancer. 2012 Aug 02; 12:336.

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Grigsby JG, Parvathaneni K, Almanza MA, Botello AM, Mondragon AA, Allen DM, Tsin AT. Effects of tamoxifen versus raloxifene on retinal capillary endothelial cell proliferation. J Ocul Pharmacol Ther. 2011 Jun; 27(3):225-33.

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