Enzyme Inhibitors

"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Descriptor ID	D004791
MeSH Number(s)	D27.505.519.389
Concept/Terms	Enzyme Inhibitors Enzyme Inhibitors Inhibitors, Enzyme

Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]

Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.

Bar chart showing 351 publications over 29 distinct years, with a maximum of 34 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	1	2
1996	1	3	4
1997	0	1	1
1998	1	6	7
1999	2	9	11
2000	3	12	15
2001	3	10	13
2002	6	18	24
2003	6	28	34
2004	6	22	28
2005	8	9	17
2006	8	20	28
2007	7	10	17
2008	7	12	19
2009	7	11	18
2010	4	13	17
2011	6	15	21
2012	7	2	9
2013	6	10	16
2014	1	5	6
2015	0	6	6
2016	6	5	11
2017	2	4	6
2018	3	6	9
2019	2	4	6
2020	2	1	3
2021	0	1	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.

Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms. Nat Commun. 2024 May 06; 15(1):3785.

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Xu C, Yadav-Samudrala BJ, Xu C, Nath B, Mistry T, Jiang W, Niphakis MJ, Cravatt BF, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S. Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms. Cells. 2022 03 02; 11(5).

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Yuan YC, Bai XL, Liu YM, Tang XY, Yuan H, Liao X. Ligand fishing based on cell surface display of enzymes for inhibitor screening. Anal Chim Acta. 2021 Apr 29; 1156:338359.

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Suzol SH, Hasan Howlader A, Galv?n AE, Radhakrishnan M, Wnuk SF, Rosen BP, Yoshinaga M. Semisynthesis of the Organoarsenical Antibiotic Arsinothricin. J Nat Prod. 2020 09 25; 83(9):2809-2813.

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Seguinot-Tarafa I, Luna N, Suarez E, Appleyard CB, Flores I. Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis. Reprod Sci. 2020 09; 27(9):1812-1820.

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Ekpenyong O, Gao X, Ma J, Cooper C, Nguyen L, Olaleye OA, Liang D, Xie H. Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases. Drug Des Devel Ther. 2020; 14:1263-1277.

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Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells. ACS Chem Neurosci. 2019 09 18; 10(9):4018-4030.

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Neupane RP, Parrish SM, Neupane JB, Yoshida WY, Yip MLR, Turkson J, Harper MK, Head JD, Williams PG. Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans. Mar Drugs. 2019 Jul 19; 17(7).

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Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 07 08; 36(1):100-114.e25.

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Young LA, O'Connor LO, de Renty C, Veldman-Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya-Mendoza A, Reimer C, Bartek J, Lau A, O'Connor MJ. Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress. Cancer Res. 2019 07 15; 79(14):3762-3775.

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