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Jayalakshmi Sridhar, PhD

TitleAssociate Chair, Chemistry Department
Faculty RankAssociate Professor
InstitutionXavier University of Louisiana
Address1 Drexeline St
New Orleans LA 70125
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    R15GM113193     (RILEY, KEVIN E)Jan 1, 2015 - Dec 31, 2018
    NIH
    Generation of Liver X Receptor Agonists with LXRb Subtype Selectivity using Modern Computational and Chemical Synthetic Methods
    Role: Co-Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Goyal N, Do C, Sridhar J, Shaik S, Thompson A, Perry T, Carter L, Foroozesh M. Design, Synthesis, and Biological Studies of Flavone-Based Esters and Acids as Potential P450 2A6 Inhibitors. Chem Res Toxicol. 2023 12 18; 36(12):1973-1979. PMID: 37963190.
      Citations: 1     Fields:    Translation:Humans
    2. Goyal N, Do C, Hill-Odom M, Beamon T, Ponnapakkam T, Liu J, Sridhar J, Huckaba T, Foroozesh M. Study of Ceramide-Flavone Analogs Showing Self-Fluorescence and Anti-Proliferation Activities. J Oncol Res Ther. 2023; 8(2). PMID: 37538786.
      Citations:    
    3. Goyal N, Sridhar J, Do C, Bratton M, Shaik S, Jiang Q, Foroozesh M. Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine. J Cancer Metastasis Treat. 2021; 7. PMID: 34722929.
      Citations:    
    4. Schroeder R, Sfondouris M, Goyal N, Komati R, Weerathunga A, Gettridge C, Stevens CLK, Jones FE, Sridhar J. Identification of New Mono/Dihydroxynaphthoquinone as Lead Agents That Inhibit the Growth of Refractive and Triple-Negative Breast Cancer Cell Lines. ACS Omega. 2019 Jun 30; 4(6):10610-10619. PMID: 31460159.
      Citations:    
    5. Foroozesh M, Sridhar J, Goyal N, Liu J. Coumarins and P450s, Studies Reported to-Date. Molecules. 2019 Apr 24; 24(8). PMID: 31022888.
      Citations: 8     Fields:    Translation:Humans
    6. Goyal N, Bongay-Williams K, Do C, Perry T, Kantrow E, Hill-Odom M, Sridhar J, Foroozesh M. DESIGN AND SYNTHESIS OF DIBENZYLFURAN BASED ETHER AND ESTER DERIVATIVES AS POTENTIAL P450 INHIBITORS. J Undergrad Chem Res. 2018; 17(4):102-104. PMID: 31363349.
      Citations:    
    7. Jha V, Goyal N, Stevens CK, Stevens E, Sridhar J. Synthetic Method to Form 2,2'-Bis(naphthoquinone) Compounds. J Org Chem. 2017 12 15; 82(24):13686-13692. PMID: 29111723.
      Citations:    Fields:    Translation:Cells
    8. Sridhar J, Goyal N, Liu J, Foroozesh M. Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date. Molecules. 2017 Jul 08; 22(7). PMID: 28698457.
      Citations: 24     Fields:    Translation:Humans
    9. Bateman ME, Strong AL, Hunter RS, Bratton MR, Komati R, Sridhar J, Riley KE, Wang G, Hayes DJ, Boue SM, Burow ME, Bunnell BA. Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow. Phytomedicine. 2017 Apr 15; 27:39-51. PMID: 28314478.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Komati R, Spadoni D, Zheng S, Sridhar J, Riley KE, Wang G. Ligands of Therapeutic Utility for the Liver X Receptors. Molecules. 2017 Jan 05; 22(1). PMID: 28067791.
      Citations: 41     Fields:    Translation:HumansCells
    11. Sridhar J, Liu J, Komati R, Schroeder R, Jiang Q, Tram P, Riley K, Foroozesh M. Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme. Drug Metab Lett. 2017; 10(4):270-277. PMID: 28000546.
      Citations: 5     Fields:    Translation:HumansCells
    12. Schroeder RL, Goyal N, Bratton M, Townley I, Pham NA, Tram P, Stone T, Geathers J, Nguyen K, Sridhar J. Identification of quinones as novel PIM1 kinase inhibitors. Bioorg Med Chem Lett. 2016 07 01; 26(13):3187-3191. PMID: 27173800.
      Citations: 6     Fields:    Translation:HumansCells
    13. Schroeder RL, Tram P, Liu J, Foroozesh M, Sridhar J. Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1). Expert Opin Ther Pat. 2016; 26(1):139-47. PMID: 26514241.
      Citations: 1     Fields:    Translation:Humans
    14. Schroeder RL, Stevens CL, Sridhar J. Small molecule tyrosine kinase inhibitors of ErbB2/HER2/Neu in the treatment of aggressive breast cancer. Molecules. 2014 Sep 23; 19(9):15196-212. PMID: 25251190.
      Citations: 37     Fields:    Translation:Humans
    15. Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M. Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. Chem Res Toxicol. 2014 Aug 18; 27(8):1431-9. PMID: 25033111.
      Citations: 3     Fields:    Translation:Cells
    16. Zheng S, Zhong Q, Xi Y, Mottamal M, Zhang Q, Schroeder RL, Sridhar J, He L, McFerrin H, Wang G. Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. J Med Chem. 2014 Aug 14; 57(15):6653-67. PMID: 25007006.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Sridhar J, Sfondouris ME, Bratton MR, Nguyen TL, Townley I, Klein Stevens CL, Jones FE. Identification of quinones as HER2 inhibitors for the treatment of trastuzumab resistant breast cancer. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):126-31. PMID: 24355130.
      Citations: 5     Fields:    Translation:HumansCells
    18. Liu J, Sridhar J, Foroozesh M. Cytochrome P450 family 1 inhibitors and structure-activity relationships. Molecules. 2013 Nov 25; 18(12):14470-95. PMID: 24287985.
      Citations: 34     Fields:    Translation:HumansAnimals
    19. Foroozesh M, Jiang Q, Sridhar J, Liu J, Dotson B, McClain E. DESIGN, SYNTHESIS, AND EVALUATION OF CARBAZOLE ANALOGS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013 Sep; 12(4):92-95. PMID: 25580095.
      Citations:    
    20. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J Med Chem. 2013 May 23; 56(10):4082-92. PMID: 23600958.
      Citations: 15     Fields:    Translation:HumansCells
    21. Foroozesh M, Jiang Q, Sridhar J, Liu J, Dotson B, McClain E. DESIGN, SYNTHESIS, AND EVALUATION OF A FAMILY OF PROPARGYL PYRIDINYL ETHERS AS POTENTIAL CYTOCHROME P450 INHIBITORS. J Undergrad Chem Res. 2013; 12(4):91-94. PMID: 25544835.
      Citations:    
    22. Sridhar J, Liu J, Foroozesh M, Stevens CL. Insights on cytochrome p450 enzymes and inhibitors obtained through QSAR studies. Molecules. 2012 Aug 03; 17(8):9283-305. PMID: 22864238.
      Citations: 18     Fields:    Translation:HumansCells
    23. Liu J, Nguyen TT, Dupart PS, Sridhar J, Zhang X, Zhu N, Stevens CL, Foroozesh M. 7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2. Chem Res Toxicol. 2012 May 21; 25(5):1047-57. PMID: 22443586.
      Citations: 11     Fields:    Translation:HumansCells
    24. Sridhar J, Liu J, Foroozesh M, Klein Stevens CL. Inhibition of cytochrome p450 enzymes by quinones and anthraquinones. Chem Res Toxicol. 2012 Feb 20; 25(2):357-65. PMID: 22185593.
      Citations: 19     Fields:    Translation:HumansAnimals
    25. Sridhar J, Ellis J, Dupart P, Liu J, Stevens CL, Foroozesh M. Development of flavone propargyl ethers as potent and selective inhibitors of cytochrome P450 enzymes 1A1 and 1A2. Drug Metab Lett. 2012; 6(4):275-84. PMID: 23506553.
      Citations: 9     Fields:    
    26. Jiang Q, Payton-Stewart F, Elliott S, Driver J, Rhodes LV, Zhang Q, Zheng S, Bhatnagar D, Boue SM, Collins-Burow BM, Sridhar J, Stevens C, McLachlan JA, Wiese TE, Burow ME, Wang G. Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26; 53(16):6153-63. PMID: 20669983.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Sridhar J, Jin P, Liu J, Foroozesh M, Stevens CL. In silico studies of polyaromatic hydrocarbon inhibitors of cytochrome P450 enzymes 1A1, 1A2, 2A6, and 2B1. Chem Res Toxicol. 2010 Mar 15; 23(3):600-7. PMID: 20078084.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    28. Sridhar J, Akula N, Pattabiraman N. Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J. 2006 Mar 24; 8(1):E204-21. PMID: 16584130.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    29. Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3beta inhibitors that block tau phosphorylation and decrease alpha-synuclein protein expression in a cellular model of Parkinson's disease. ChemMedChem. 2006 Feb; 1(2):256-66. PMID: 16892358.
      Citations: 42     Fields:    Translation:HumansCells
    30. Sridhar J, Akula N, Sivanesan D, Narasimhan M, Rathinavelu A, Pattabiraman N. Identification of novel angiogenesis inhibitors. Bioorg Med Chem Lett. 2005 Sep 15; 15(18):4125-9. PMID: 15993586.
      Citations: 1     Fields:    Translation:HumansCells
    31. Akula N, Bhalla J, Sridhar J, Pattabiraman N. Binding modes of 6,7 di-substituted 4-anilinoquinoline-3-carbonitriles to EGFR. Bioorg Med Chem Lett. 2004 Jul 05; 14(13):3397-400. PMID: 15177440.
      Citations:    Fields:    Translation:Cells
    32. Sridhar J, Wei ZL, Nowak I, Lewin NE, Ayres JA, Pearce LV, Blumberg PM, Kozikowski AP. New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity. J Med Chem. 2003 Sep 11; 46(19):4196-204. PMID: 12954072.
      Citations: 6     Fields:    Translation:HumansCells
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