Cytochrome P-450 CYP1A1

"Cytochrome P-450 CYP1A1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

Descriptor ID	D019363
MeSH Number(s)	D08.244.453.005.332 D08.244.453.100.500 D08.811.682.690.708.170.010.277 D08.811.682.690.708.170.020.500 D12.776.422.220.453.010.332 D12.776.422.220.453.100.500
Concept/Terms	Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 Cytochrome P 450 CYP1A1 EROD Ethoxyresorufin Dealkylase Ethylresorufin O-Deethylase CYP1A1 Protein 7-Ethoxyresorufin O-Deethylase CYP1A1 Cytochrome P450 IA1 Ethoxyresorufin O-Deethylase CYP 1A1

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP1A1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Aryl Hydrocarbon Hydroxylases [D08.244.453.005]
Cytochrome P-450 CYP1A1 [D08.244.453.005.332]
Cytochrome P450 Family 1 [D08.244.453.100]
Cytochrome P-450 CYP1A1 [D08.244.453.100.500]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.010.277]
Cytochrome P450 Family 1 [D08.811.682.690.708.170.020]
Cytochrome P-450 CYP1A1 [D08.811.682.690.708.170.020.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
Cytochrome P-450 CYP1A1 [D12.776.422.220.453.010.332]
Cytochrome P450 Family 1 [D12.776.422.220.453.100]
Cytochrome P-450 CYP1A1 [D12.776.422.220.453.100.500]

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 CYP1A1".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP1A1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP1A1" by people in this website by year, and whether "Cytochrome P-450 CYP1A1" was a major or minor topic of these publications.

Bar chart showing 30 publications over 14 distinct years, with a maximum of 5 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	1	2
2003	1	2	3
2006	2	3	5
2008	2	0	2
2009	0	3	3
2010	0	1	1
2012	2	0	2
2013	1	1	2
2014	1	1	2
2015	0	3	3
2016	0	1	1
2017	2	0	2
2018	0	1	1
2024	0	1	1

Below are the most recent publications written about "Cytochrome P-450 CYP1A1" by people in Profiles.

Ferguson DT, Taka E, Messeha S, Flores-Rozas H, Reed SL, Redmond BV, Soliman KFA, Kanga KJW, Darling-Reed SF. The Garlic Compound, Diallyl Trisulfide, Attenuates Benzo[a]Pyrene-Induced Precancerous Effect through Its Antioxidant Effect, AhR Inhibition, and Increased DNA Repair in Human Breast Epithelial Cells. Nutrients. 2024 Jan 19; 16(2).

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Huderson AC, Rekha Devi PV, Niaz MS, Adunyah SE, Ramesh A. Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis. Invest New Drugs. 2019 04; 37(2):238-251.

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Sridhar J, Goyal N, Liu J, Foroozesh M. Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date. Molecules. 2017 Jul 08; 22(7).

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Sridhar J, Liu J, Komati R, Schroeder R, Jiang Q, Tram P, Riley K, Foroozesh M. Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme. Drug Metab Lett. 2017; 10(4):270-277.

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Yang F, Yang H, Ramesh A, Goodwin JS, Okoro EU, Guo Z. Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One. 2016; 11(9):e0162561.

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Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica. 2016; 46(3):211-24.

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Ghotbaddini M, Powell JB. The AhR Ligand, TCDD, Regulates Androgen Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells. Int J Environ Res Public Health. 2015 Jul 06; 12(7):7506-18.

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Humphrey-Johnson A, Abukalam R, Eltom SE. Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett. 2015 Mar 04; 233(2):59-67.

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Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M. Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. Chem Res Toxicol. 2014 Aug 18; 27(8):1431-9.

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Mantey JA, Rekhadevi PV, Diggs DL, Ramesh A. Metabolism of benzo(a)pyrene by subcellular fractions of gastrointestinal (GI) tract and liver in Apc(Min) mouse model of colon cancer. Tumour Biol. 2014 May; 35(5):4929-35.

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