Cytochrome P-450 CYP2D6

"Cytochrome P-450 CYP2D6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

Descriptor ID	D019389
MeSH Number(s)	D08.244.453.005.600 D08.244.453.491.372 D08.811.682.690.708.170.010.600 D08.811.682.690.708.170.450.368 D12.776.422.220.453.010.600 D12.776.422.220.453.491.368
Concept/Terms	Cytochrome P-450 CYP2D6 Cytochrome P-450 CYP2D6 CYP2D6, Cytochrome P-450 Cytochrome P 450 CYP2D6 P-450 CYP2D6, Cytochrome Sparteine Monooxygenase Monooxygenase, Sparteine Cytochrome P450 2D6 P450 2D6, Cytochrome Debrisoquine 4-Monooxygenase 4-Monooxygenase, Debrisoquine Debrisoquine 4 Monooxygenase Imipramine 2-Hydroxylase 2-Hydroxylase, Imipramine Imipramine 2 Hydroxylase CYP2D6 CYP 2D6 Debrisoquine 4-Hydroxylase 4-Hydroxylase, Debrisoquine Debrisoquine 4 Hydroxylase Debrisoquine Hydroxylase Hydroxylase, Debrisoquine

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2D6".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Aryl Hydrocarbon Hydroxylases [D08.244.453.005]
Cytochrome P-450 CYP2D6 [D08.244.453.005.600]
Cytochrome P450 Family 2 [D08.244.453.491]
Cytochrome P-450 CYP2D6 [D08.244.453.491.372]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]
Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.450.368]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
Cytochrome P-450 CYP2D6 [D12.776.422.220.453.010.600]
Cytochrome P450 Family 2 [D12.776.422.220.453.491]
Cytochrome P-450 CYP2D6 [D12.776.422.220.453.491.368]

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 CYP2D6".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2D6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP2D6" by people in this website by year, and whether "Cytochrome P-450 CYP2D6" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2010 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2007	1	1	2
2010	2	0	2
2012	0	1	1
2013	1	0	1
2015	1	0	1
2016	0	1	1
2022	0	2	2

Below are the most recent publications written about "Cytochrome P-450 CYP2D6" by people in Profiles.

Mondal T, Loffredo CA, Simhadri J, Nunlee-Bland G, Korba B, Johnson J, Cotin S, Moses G, Quartey R, Howell CD, Noreen Z, Arif M, Ghosh S. Insights on the pathogenesis of type 2 diabetes as revealed by signature genomic classifiers in an African American population in the Washington, DC area. Diabetes Metab Res Rev. 2023 01; 39(1):e3589.

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Mondal T, Loffredo CA, Trnovec T, Palkovicova Murinova L, Noreen Z, Nnanabu T, Conka K, Drobna B, Ghosh S. Gene expression signatures in PCB-exposed Slovak children in relation to their environmental exposures and socio-physical characteristics. Environ Sci Pollut Res Int. 2022 Aug; 29(40):60531-60541.

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C?spedes-Garro C, Naranjo MG, Rodrigues-Soares F, LLerena A, Duconge J, Montan?-Jaime LK, Roblejo H, Fari?as H, Campos ML, Ram?rez R, Serrano V, Villagr?n CI, Pe?as-LLed? EM. Pharmacogenetic research activity in Central America and the Caribbean: a systematic review. Pharmacogenomics. 2016 10; 17(15):1707-1724.

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Zhong Q, Zhang C, Zhang Q, Miele L, Zheng S, Wang G. Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status. BMC Cancer. 2015 Sep 09; 15:625.

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Duconge J, Cadilla CL. CYP2D6's functional status associated with the length of hospitalization stay in psychiatric patients: a twist in the tale or evidence that matters? Biomark Med. 2013 Dec; 7(6):913-4.

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Jiao GS, Kim S, Moayeri M, Crown D, Thai A, Cregar-Hernandez L, McKasson L, Sankaran B, Lehrer A, Wong T, Johns L, Margosiak SA, Leppla SH, Johnson AT. Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15; 22(6):2242-6.

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Gonz?lez-Tejera G, Gaedigk A, Corey S. Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients. P R Health Sci J. 2010 Sep; 29(3):299-304.

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Gaedigk A, Isidoro-Garc?a M, Pearce RE, S?nchez S, Garc?a-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S. Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep; 66(9):859-64.

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Tamayo JM, Pumariega A, Rothe EM, Kelsey D, Allen AJ, V?lez-Borr?s J, Williams D, Anderson SG, Durell TM. Latino versus Caucasian response to atomoxetine in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2008 Feb; 18(1):44-53.

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Ozdemir V, Bertilsson L, Miura J, Carpenter E, Reist C, Harper P, Wid?n J, Svensson JO, Albers LJ, Kennedy JL, Endrenyi L, Kalow W. CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6-serotonin-dopamine crosstalk revisited. Pharmacogenet Genomics. 2007 May; 17(5):339-47.

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