Cytochrome P-450 CYP2D6

"Cytochrome P-450 CYP2D6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

Descriptor ID	D019389
MeSH Number(s)	D08.244.453.005.600 D08.244.453.491.372 D08.811.682.690.708.170.010.600 D08.811.682.690.708.170.450.368 D12.776.422.220.453.010.600 D12.776.422.220.453.491.368
Concept/Terms	Cytochrome P-450 CYP2D6 Cytochrome P-450 CYP2D6 CYP2D6, Cytochrome P-450 Cytochrome P 450 CYP2D6 P-450 CYP2D6, Cytochrome Sparteine Monooxygenase Monooxygenase, Sparteine Cytochrome P450 2D6 P450 2D6, Cytochrome Debrisoquine 4-Monooxygenase 4-Monooxygenase, Debrisoquine Debrisoquine 4 Monooxygenase Imipramine 2-Hydroxylase 2-Hydroxylase, Imipramine Imipramine 2 Hydroxylase CYP2D6 CYP 2D6 Debrisoquine 4-Hydroxylase 4-Hydroxylase, Debrisoquine Debrisoquine 4 Hydroxylase Debrisoquine Hydroxylase Hydroxylase, Debrisoquine

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2D6".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Aryl Hydrocarbon Hydroxylases [D08.244.453.005]
Cytochrome P-450 CYP2D6 [D08.244.453.005.600]
Cytochrome P450 Family 2 [D08.244.453.491]
Cytochrome P-450 CYP2D6 [D08.244.453.491.372]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Aryl Hydrocarbon Hydroxylases [D08.811.682.690.708.170.010]
Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.010.600]
Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
Cytochrome P-450 CYP2D6 [D08.811.682.690.708.170.450.368]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Aryl Hydrocarbon Hydroxylases [D12.776.422.220.453.010]
Cytochrome P-450 CYP2D6 [D12.776.422.220.453.010.600]
Cytochrome P450 Family 2 [D12.776.422.220.453.491]
Cytochrome P-450 CYP2D6 [D12.776.422.220.453.491.368]

Below are MeSH descriptors whose meaning is related to "Cytochrome P-450 CYP2D6".

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2D6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP2D6" by people in this website by year, and whether "Cytochrome P-450 CYP2D6" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2010 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2007	1	1	2
2010	2	0	2
2012	0	1	1
2013	1	0	1
2015	1	0	1
2016	0	1	1
2022	0	2	2

Below are the most recent publications written about "Cytochrome P-450 CYP2D6" by people in Profiles.

Bishop JR, Zhou C, Gaedigk A, Krone B, Kittles R, Cook EH, Newcorn JH, Stein MA. Dopamine Transporter and CYP2D6 Gene Relationships with Attention-Deficit/Hyperactivity Disorder Treatment Response in the Methylphenidate and Atomoxetine Crossover Study. J Child Adolesc Psychopharmacol. 2024 Dec; 34(10):458-469.

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Mondal T, Loffredo CA, Simhadri J, Nunlee-Bland G, Korba B, Johnson J, Cotin S, Moses G, Quartey R, Howell CD, Noreen Z, Arif M, Ghosh S. Insights on the pathogenesis of type 2 diabetes as revealed by signature genomic classifiers in an African American population in the Washington, DC area. Diabetes Metab Res Rev. 2023 01; 39(1):e3589.

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Mondal T, Loffredo CA, Trnovec T, Palkovicova Murinova L, Noreen Z, Nnanabu T, Conka K, Drobna B, Ghosh S. Gene expression signatures in PCB-exposed Slovak children in relation to their environmental exposures and socio-physical characteristics. Environ Sci Pollut Res Int. 2022 Aug; 29(40):60531-60541.

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C?spedes-Garro C, Naranjo MG, Rodrigues-Soares F, LLerena A, Duconge J, Montan?-Jaime LK, Roblejo H, Fari?as H, Campos ML, Ram?rez R, Serrano V, Villagr?n CI, Pe?as-LLed? EM. Pharmacogenetic research activity in Central America and the Caribbean: a systematic review. Pharmacogenomics. 2016 10; 17(15):1707-1724.

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Zhong Q, Zhang C, Zhang Q, Miele L, Zheng S, Wang G. Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status. BMC Cancer. 2015 Sep 09; 15:625.

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Duconge J, Cadilla CL. CYP2D6's functional status associated with the length of hospitalization stay in psychiatric patients: a twist in the tale or evidence that matters? Biomark Med. 2013 Dec; 7(6):913-4.

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Jiao GS, Kim S, Moayeri M, Crown D, Thai A, Cregar-Hernandez L, McKasson L, Sankaran B, Lehrer A, Wong T, Johns L, Margosiak SA, Leppla SH, Johnson AT. Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15; 22(6):2242-6.

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Gonz?lez-Tejera G, Gaedigk A, Corey S. Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Rican psychiatry patients: a preliminary report and potential implications for breast cancer patients. P R Health Sci J. 2010 Sep; 29(3):299-304.

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Gaedigk A, Isidoro-Garc?a M, Pearce RE, S?nchez S, Garc?a-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S. Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep; 66(9):859-64.

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Tamayo JM, Pumariega A, Rothe EM, Kelsey D, Allen AJ, V?lez-Borr?s J, Williams D, Anderson SG, Durell TM. Latino versus Caucasian response to atomoxetine in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2008 Feb; 18(1):44-53.

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