Cytochrome P-450 CYP2E1

"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.

Descriptor ID	D019392
MeSH Number(s)	D08.244.453.491.375 D08.811.682.662.582.338 D08.811.682.690.708.170.450.375 D12.776.422.220.453.491.375
Concept/Terms	Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP2E1 Cytochrome P 450 CYP2E1 Cytochrome P-450-J Cytochrome P 450 J 4-Nitrophenol-2-Hydroxylase 4 Nitrophenol 2 Hydroxylase Dimethylnitrosamine N-Demethylase Dimethylnitrosamine N Demethylase Cytochrome P450 2E1 N-Nitrosodimethylamine Demethylase N Nitrosodimethylamine Demethylase CYP 2E1 Cytochrome P-450 IIE1 Cytochrome P 450 IIE1 CYP IIE1 CYPIIE1 Cytochrome P-450 (ALC) CYP2E1

Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 2 [D08.244.453.491]
Cytochrome P-450 CYP2E1 [D08.244.453.491.375]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxidoreductases Acting on CH-NH Group Donors [D08.811.682.662]
Oxidoreductases, N-Demethylating [D08.811.682.662.582]
Cytochrome P-450 CYP2E1 [D08.811.682.662.582.338]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 2 [D08.811.682.690.708.170.450]
Cytochrome P-450 CYP2E1 [D08.811.682.690.708.170.450.375]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 2 [D12.776.422.220.453.491]
Cytochrome P-450 CYP2E1 [D12.776.422.220.453.491.375]

Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in this website by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2002	0	1	1
2003	1	0	1
2004	1	0	1
2005	2	0	2
2006	0	1	1
2007	1	1	2
2008	0	1	1
2009	1	0	1
2012	1	0	1
2013	1	1	2
2015	1	2	3
2017	2	0	2
2024	0	1	1

Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles.

Ofosu-Boateng M, Shaik F, Choi S, Ekuban FA, Gebreyesus LH, Twum E, Nnamani DO, Yeyeodu ST, Yadak N, Collier DM, Gyamfi MA. High-fat diet induced obesity promotes inflammation, oxidative stress, and hepatotoxicity in female FVB/N mice. Biofactors. 2024 May-Jun; 50(3):572-591.

View in: PubMed
Kumar S, Sinha N, Gerth KA, Rahman MA, Yallapu MM, Midde NM. Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications. Biochem Biophys Res Commun. 2017 09 23; 491(3):675-680.

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Abdelmegeed MA, Choi Y, Godlewski G, Ha SK, Banerjee A, Jang S, Song BJ. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. Sci Rep. 2017 01 04; 7:39764.

View in: PubMed
Jang S, Yu LR, Abdelmegeed MA, Gao Y, Banerjee A, Song BJ. Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. Redox Biol. 2015 Dec; 6:552-564.

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Spruiell K, Gyamfi AA, Yeyeodu ST, Richardson RM, Gonzalez FJ, Gyamfi MA. Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity. J Pharmacol Exp Ther. 2015 Sep; 354(3):459-70.

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Rao PS, Midde NM, Miller DD, Chauhan S, Kumar A, Kumar S. Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1. Curr Drug Metab. 2015; 16(6):486-503.

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Banerjee A, Abdelmegeed MA, Jang S, Song BJ. Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators. PLoS One. 2013; 8(10):e76850.

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Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Free Radic Biol Med. 2013 Dec; 65:1238-1245.

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Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ. Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012 Oct; 57(4):860-6.

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Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 2010 Jan; 82(1):96-104.

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