Protease Inhibitors

"Protease Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Descriptor ID	D011480
MeSH Number(s)	D27.505.519.389.745
Concept/Terms	Protease Inhibitors Protease Inhibitors Inhibitors, Protease Endopeptidase Inhibitors Inhibitors, Endopeptidase Protease Inhibitor Inhibitor, Protease Peptide Hydrolase Inhibitors Hydrolase Inhibitors, Peptide Inhibitors, Peptide Hydrolase Peptide Peptidohydrolase Inhibitors Inhibitors, Peptide Peptidohydrolase Peptidohydrolase Inhibitors, Peptide Protease Antagonists Antagonists, Protease Antiproteases Peptidase Inhibitors Inhibitors, Peptidase

Below are MeSH descriptors whose meaning is more general than "Protease Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
Protease Inhibitors [D27.505.519.389.745]

Below are MeSH descriptors whose meaning is related to "Protease Inhibitors".

Below are MeSH descriptors whose meaning is more specific than "Protease Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protease Inhibitors" by people in this website by year, and whether "Protease Inhibitors" was a major or minor topic of these publications.

Bar chart showing 41 publications over 17 distinct years, with a maximum of 6 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	1	2
1997	0	1	1
1999	1	1	2
2002	1	0	1
2003	2	1	3
2004	3	1	4
2005	3	0	3
2008	2	2	4
2009	0	2	2
2011	5	1	6
2012	1	2	3
2016	2	1	3
2017	1	0	1
2020	0	2	2
2022	0	2	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Protease Inhibitors" by people in Profiles.

Holmes J, Islam SM, Milligan KA. Exploring Cannabinoids as Potential Inhibitors of SARS-CoV-2 Papain-like Protease: Insights from Computational Analysis and Molecular Dynamics Simulations. Viruses. 2024 May 30; 16(6).

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Samanta PN, Majumdar D, Leszczynski J. Elucidating Atomistic Insight into the Dynamical Responses of the SARS-CoV-2 Main Protease for the Binding of Remdesivir Analogues: Leveraging Molecular Mechanics To Decode the Inhibition Mechanism. J Chem Inf Model. 2023 06 12; 63(11):3404-3422.

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Brooks KM, Pinilla M, Stek AM, Shapiro DE, Barr E, Febo IL, Paul ME, Deville JG, George K, Knowles K, Rungruengthanakit K, Browning R, Chakhtoura N, Capparelli EV, Mirochnick M, Best BM. Pharmacokinetics of Tenofovir Alafenamide With Boosted Protease Inhibitors in Pregnant and Postpartum Women Living With HIV: Results From IMPAACT P1026s. J Acquir Immune Defic Syndr. 2022 07 01; 90(3):343-350.

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Kumar V, Kar S, De P, Roy K, Leszczynski J. Identification of potential antivirals against 3CLpro enzyme for the treatment of SARS-CoV-2: A multi-step virtual screening study. SAR QSAR Environ Res. 2022 May; 33(5):357-386.

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Toropov AA, Toropova AP, Veselinovic AM, Leszczynska D, Leszczynski J. SARS-CoV Mpro inhibitory activity of aromatic disulfide compounds: QSAR model. J Biomol Struct Dyn. 2022 02; 40(2):780-786.

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Kapusta K, Kar S, Collins JT, Franklin LM, Kolodziejczyk W, Leszczynski J, Hill GA. Protein reliability analysis and virtual screening of natural inhibitors for SARS-CoV-2 main protease (Mpro) through docking, molecular mechanic & dynamic, and ADMET profiling. J Biomol Struct Dyn. 2021 10; 39(17):6810-6827.

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Burton LJ, Dougan J, Jones J, Smith BN, Randle D, Henderson V, Odero-Marah VA. Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor. Mol Cell Biol. 2017 03 01; 37(5).

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Wilder CL, Walton C, Watson V, Stewart FAA, Johnson J, Peyton SR, Payne CK, Odero-Marah V, Platt MO. Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells. Int J Biochem Cell Biol. 2016 10; 79:199-208.

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Hossain A, Heron D, Davenport I, Huckaba T, Graves R, Mandal T, Muniruzzaman S, Wang S, Bhattacharjee PS. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 08; 149:100-106.

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Byler KG, Collins JT, Ogungbe IV, Setzer WN. Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation. Comput Biol Chem. 2016 Oct; 64:163-184.

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