Trypanocidal Agents

"Trypanocidal Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

Descriptor ID	D014344
MeSH Number(s)	D27.505.954.122.250.100.875
Concept/Terms	Trypanocidal Agents Trypanocidal Agents Agents, Trypanocidal Trypanocidal Drugs Drugs, Trypanocidal Trypanosomicides Trypanocides Trypanosomicidal Agents Agents, Trypanosomicidal

Below are MeSH descriptors whose meaning is more general than "Trypanocidal Agents".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Therapeutic Uses [D27.505.954]
Anti-Infective Agents [D27.505.954.122]
Antiparasitic Agents [D27.505.954.122.250]
Antiprotozoal Agents [D27.505.954.122.250.100]
Trypanocidal Agents [D27.505.954.122.250.100.875]

Below are MeSH descriptors whose meaning is related to "Trypanocidal Agents".

Below are MeSH descriptors whose meaning is more specific than "Trypanocidal Agents".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Trypanocidal Agents" by people in this website by year, and whether "Trypanocidal Agents" was a major or minor topic of these publications.

Bar chart showing 30 publications over 16 distinct years, with a maximum of 4 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2004	1	0	1
2006	2	0	2
2007	1	0	1
2009	2	1	3
2010	1	0	1
2011	2	0	2
2012	2	0	2
2013	2	1	3
2014	1	0	1
2015	4	0	4
2016	1	0	1
2018	3	0	3
2019	2	0	2
2020	1	0	1
2023	2	0	2

Below are the most recent publications written about "Trypanocidal Agents" by people in Profiles.

Ajayi O, Metibemu DS, Crown O, Adeyinka OS, Kaiser M, Shoji N, Silva M, Rodriguez A, Ogungbe IV. Discovery of an orally active nitrothiophene-based antitrypanosomal agent. Eur J Med Chem. 2024 Jan 05; 263:115954.

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Silva Grij? Farani P, Iandra da Silva Ferreira B, Begum K, Vilar-Pereira G, Pereira IR, Fern?ndez-Figueroa EA, Cardenas-Ovando RA, Almeida IC, Roy S, Lannes-Vieira J, Moreira OC. Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy. PLoS Negl Trop Dis. 2023 03; 17(3):e0011223.

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Alonso-Padilla J, Abril M, Alarc?n de Noya B, Almeida IC, Angheben A, Araujo Jorge T, Chatelain E, Esteva M, Gasc?n J, Grijalva MJ, Guhl F, Hasslocher-Moreno AM, L?pez MC, Luquetti A, Noya O, Pinazo MJ, Ramsey JM, Ribeiro I, Ruiz AM, Schijman AG, Sosa-Estani S, Thomas MC, Torrico F, Zrein M, Picado A. Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus. PLoS Negl Trop Dis. 2020 04; 14(4):e0008035.

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Villalta F, Rachakonda G. Advances in preclinical approaches to Chagas disease drug discovery. Expert Opin Drug Discov. 2019 11; 14(11):1161-1174.

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Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pav?o BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC. Successful Aspects of the Coadministration of Sterol 14a-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi. ACS Infect Dis. 2019 03 08; 5(3):365-371.

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Zhang H, Collins J, Nyamwihura R, Ware S, Kaiser M, Ogungbe IV. Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent. Bioorg Med Chem Lett. 2018 05 15; 28(9):1647-1651.

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Carothers S, Nyamwihura R, Collins J, Zhang H, Park H, Setzer WN, Ogungbe IV. Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent. Molecules. 2018 Feb 08; 23(2).

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Torrico F, Gascon J, Ortiz L, Alonso-Vega C, Pinazo MJ, Schijman A, Almeida IC, Alves F, Strub-Wourgaft N, Ribeiro I. Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial. Lancet Infect Dis. 2018 04; 18(4):419-430.

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Ogindo CO, Khraiwesh MH, George M, Brandy Y, Brandy N, Gugssa A, Ashraf M, Abbas M, Southerland WM, Lee CM, Bakare O, Fang Y. Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives. Bioorg Med Chem. 2016 08 15; 24(16):3849-55.

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Hoekstra WJ, Hargrove TY, Wawrzak Z, da Gama Jaen Batista D, da Silva CF, Nefertiti AS, Rachakonda G, Schotzinger RJ, Villalta F, Soeiro Mde N, Lepesheva GI. Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi. Antimicrob Agents Chemother. 2016 Feb; 60(2):1058-66.

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