Below are the most recent publications written about "Trypanocidal Agents" by people in Profiles.
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Vilar-Pereira G, Casta?o-Barrios LM, Pereira IR, da Silva Pinheiro AP, do Esp?rito Santo Prot?sio da Silva T, Hernandez-Velasco LL, Silva Grij? Farani P, Kulkarni A, Roy S, Mata Dos Santos HA, de Oliveira Lopes R, Tinoco LW, Britto C, Moreira OC, Silva AA, Lannes-Vieira J. Combined benznidazole and pentoxifylline therapy improves behavioral and cognitive changes in association with the regulation of systemic inflammatory profile in chronic experimental Chagas disease. PLoS One. 2025; 20(11):e0334708.
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Ajayi O, Metibemu DS, Crown O, Adeyinka OS, Kaiser M, Shoji N, Silva M, Rodriguez A, Ogungbe IV. Discovery of an orally active nitrothiophene-based antitrypanosomal agent. Eur J Med Chem. 2024 Jan 05; 263:115954.
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Silva Grij? Farani P, Iandra da Silva Ferreira B, Begum K, Vilar-Pereira G, Pereira IR, Fern?ndez-Figueroa EA, Cardenas-Ovando RA, Almeida IC, Roy S, Lannes-Vieira J, Moreira OC. Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy. PLoS Negl Trop Dis. 2023 03; 17(3):e0011223.
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Alonso-Padilla J, Abril M, Alarc?n de Noya B, Almeida IC, Angheben A, Araujo Jorge T, Chatelain E, Esteva M, Gasc?n J, Grijalva MJ, Guhl F, Hasslocher-Moreno AM, L?pez MC, Luquetti A, Noya O, Pinazo MJ, Ramsey JM, Ribeiro I, Ruiz AM, Schijman AG, Sosa-Estani S, Thomas MC, Torrico F, Zrein M, Picado A. Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus. PLoS Negl Trop Dis. 2020 04; 14(4):e0008035.
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Villalta F, Rachakonda G. Advances in preclinical approaches to Chagas disease drug discovery. Expert Opin Drug Discov. 2019 11; 14(11):1161-1174.
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Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pav?o BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC. Successful Aspects of the Coadministration of Sterol 14a-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi. ACS Infect Dis. 2019 03 08; 5(3):365-371.
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Zhang H, Collins J, Nyamwihura R, Ware S, Kaiser M, Ogungbe IV. Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent. Bioorg Med Chem Lett. 2018 05 15; 28(9):1647-1651.
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Carothers S, Nyamwihura R, Collins J, Zhang H, Park H, Setzer WN, Ogungbe IV. Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent. Molecules. 2018 Feb 08; 23(2).
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Torrico F, Gascon J, Ortiz L, Alonso-Vega C, Pinazo MJ, Schijman A, Almeida IC, Alves F, Strub-Wourgaft N, Ribeiro I. Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial. Lancet Infect Dis. 2018 04; 18(4):419-430.
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Ogindo CO, Khraiwesh MH, George M, Brandy Y, Brandy N, Gugssa A, Ashraf M, Abbas M, Southerland WM, Lee CM, Bakare O, Fang Y. Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives. Bioorg Med Chem. 2016 08 15; 24(16):3849-55.