Viral Nonstructural Proteins

"Viral Nonstructural Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins encoded by a VIRAL GENOME that are produced in the organisms they infect, but not packaged into the VIRUS PARTICLES. Some of these proteins may play roles within the infected cell during VIRUS REPLICATION or act in regulation of virus replication or VIRUS ASSEMBLY.

Descriptor ID	D017361
MeSH Number(s)	D12.776.964.900
Concept/Terms	Viral Nonstructural Proteins Viral Nonstructural Proteins Proteins, Viral Nonstructural NS Proteins, Viral Proteins, Viral NS Viral Nonstructural Protein Nonstructural Protein, Viral Protein, Viral Nonstructural Viral NS Proteins Nonstructural Proteins, Viral Viral Non-Structural Proteins Non-Structural Proteins, Viral Proteins, Viral Non-Structural Viral Non Structural Proteins Viral Nonstructural Proteins NS2 Viral Nonstructural Proteins NS2 Viral Nonstructural Proteins NS1 Viral Nonstructural Proteins NS1

Below are MeSH descriptors whose meaning is more general than "Viral Nonstructural Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Viral Proteins [D12.776.964]
Viral Nonstructural Proteins [D12.776.964.900]

Below are MeSH descriptors whose meaning is related to "Viral Nonstructural Proteins".

Below are MeSH descriptors whose meaning is more specific than "Viral Nonstructural Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Viral Nonstructural Proteins" by people in this website by year, and whether "Viral Nonstructural Proteins" was a major or minor topic of these publications.

Bar chart showing 31 publications over 15 distinct years, with a maximum of 5 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2007	1	0	1
2010	0	1	1
2011	4	1	5
2012	1	0	1
2013	2	0	2
2014	1	0	1
2016	2	1	3
2017	0	2	2
2018	1	0	1
2019	1	2	3
2020	2	2	4
2021	1	2	3
2023	0	1	1
2024	2	0	2

Below are the most recent publications written about "Viral Nonstructural Proteins" by people in Profiles.

Adeyinka OS, Metibemu DS, Hampton T, Ojobor JC, Crown O, Falode J, Barrera MD, Alem F, Narayanan A, Ogungbe IV. Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection. Eur J Med Chem. 2026 Apr 15; 308:118696.

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Cardona-Ospina JA, Roy V, Marcano-Jim?nez DE, Bos S, Duarte E, Zambrana JV, Bal A, An BK, Dias AG, Zhiteneva J, Huffaker J, Montenegro C, Kuan G, Ramos-Benitez MJ, Balmaseda A, Alter G, Harris E. IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans. Nat Immunol. 2026 Jan; 27(1):126-134.

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Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity. Viruses. 2024 08 16; 16(8).

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Metibemu DS, Adeyinka OS, Falode J, Crown O, Ogungbe IV. Inhibitors of the Structural and Nonstructural Proteins of Alphaviruses. ACS Infect Dis. 2024 08 09; 10(8):2507-2524.

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Jacobson JM, Zahrieh D, Strand CA, Cruz-Correa M, Pungpapong S, Roberts LR, Mandrekar SJ, Rodriguez LM, Boyer J, Marrero I, Kraynyak KA, Morrow MP, Sylvester AJ, Pawlicki JM, Gillespie E, Barranco E, Richmond E, Umar A, Weiner DB, Limburg PJ. Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) Infection. Cancer Prev Res (Phila). 2023 03 01; 16(3):163-173.

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Medina FA, Vila F, Premkumar L, Lorenzi O, Paz-Bailey G, Alvarado LI, Rivera-Amill V, de Silva A, Waterman S, Mu?oz-Jord?n J. Capacity of a Multiplex IgM Antibody Capture ELISA to Differentiate Zika and Dengue Virus Infections in Areas of Concurrent Endemic Transmission. Am J Trop Med Hyg. 2021 12 20; 106(2):585-592.

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Hsieh SC, Tsai WY, Tsai JJ, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK. Identification of Anti-Premembrane Antibody as a Serocomplex-Specific Marker To Discriminate Zika, Dengue, and West Nile Virus Infections. J Virol. 2021 09 09; 95(19):e0061921.

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Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Potential Dual Role of West Nile Virus NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication. Viruses. 2021 01 31; 13(2).

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Jung LS, Gund TM, Narayan M. Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment. Protein J. 2020 12; 39(6):619-630.

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Wan S, Cao S, Wang X, Zhou Y, Yan W, Gu X, Wu TC, Pang X. Generation and preliminary characterization of vertebrate-specific replication-defective Zika virus. Virology. 2021 01 02; 552:73-82.

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