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Vivek R. Nerurkar, PhD

TitleChair
Faculty RankProfessor and Chair
InstitutionUniversity of Hawaii
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921668
ORCID ORCID Icon0000-0002-2044-2784 Additional info
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    Collapse Overview 
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    Dr. Vivek R. Nerurkar, who joined the University of Hawaii at Manoa (UHM) in 1994, to develop the Research Centers in Minority Institutions (RCMI), NCRR-supported Retrovirology Activity following a five-year appointment as a Visiting Fellow and Visiting Associate of the NINDS, NIH, has mentored over 100 undergraduate and graduate students, technicians and postdoctoral fellows in laboratory-based research during the past 25 years. Dr. Nerurkar’s major area of research interest is in infectious diseases, specifically to study the pathogenesis of orphan diseases and orphan microbial agents. Over the past two decades he has conducted research in the diverse but related areas of virology, specifically neurovirology.

    Dr. Nerurkar conducts research on pathogenesis of West Nile virus-associated meningoencephalitis and pathogenesis of the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). A talented virologist, Dr. Nerurkar, has extensive experience in classical and molecular microbiological techniques, as documented in publications appearing in peer-reviewed journals and in successful grant applications from local and national agencies. He has utilized molecular methods to study a wide range of emerging and re-emerging microbial pathogens. Dr. Nerurkar has collaborated nationally and internationally with investigators from various ethnic backgrounds. He has extensive experience of conducting research in international arena and his abilities to train minority students, enrolled at the UHM (a minority institution) and international students and postdoctoral fellows, is well documented in the form of collaborative publications. He is member of the graduate faculty of the Department of Cell and Molecular Biology (CMB), JABSOM; Department of Molecular Biosciences and Biosystems Engineering (MBBE), College of Tropical Agriculture and Human Resources (CTAHR); and Department of Microbiology, College of Natural Sciences (CNS), UHM. He is part of the NIH Short Term Education Program for Underrepresented Persons (STEP UP) Summer program, which trains high school and undergraduate students in laboratory research. He is also a mentor of the NIMH, NIH R25 grant, which trains minorities and other disadvantaged students and faculty in conducting research on mental health related issues. Dr. Nerurkar will serve as a Core Director and Mentor on this proposal.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zorilla R, Ching LL, Elisara T, Kramer K, Nerurkar VR. Re-Emerging, Under-Recognized Zoonotic, and Neglected Tropical Diseases in Hawai'i. Jpn J Infect Dis. 2024 Jul 24; 77(4):187-200. PMID: 38825457.
      Citations:    Fields:    Translation:HumansAnimals
    2. Yoon H, Dean LS, Jiyarom B, Khadka VS, Deng Y, Nerurkar VR, Chow DC, Shikuma CM, Devendra G, Koh Y, Park J. Single-cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptoms. Front Immunol. 2023; 14:1268510. PMID: 38259488.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ravi K, Kaur T, Khan AS, Pope B, Nguyen KY, Muralidhar K, Krupp K, Hernandez BY, Angela S, Madhivanan P, Nerurkar VR. Oral Human Papillomavirus Infection among Smokeless Tobacco-using Tribal Women in Mysuru, India. Indian J Community Med. 2023 Sep-Oct; 48(5):775-780. PMID: 37970149.
      Citations:    
    4. Dai YC, Lin YC, Ching LL, Tsai JJ, Ishikawa K, Tsai WY, Chen JJ, Nerurkar VR, Wang WK. Determining the Time of Booster Dose Based on the Half-Life and Neutralization Titers against SARS-CoV-2 Variants of Concern in Fully Vaccinated Individuals. Microbiol Spectr. 2023 08 17; 11(4):e0408122. PMID: 37428104.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    5. Giannakopoulos S, Strange DP, Jiyarom B, Abdelaal O, Bradshaw AW, Nerurkar VR, Ward MA, Bakse J, Yap J, Vanapruks S, Boisvert WA, Tallquist MD, Shikuma C, Sadri-Ardekani H, Clapp P, Murphy SV, Verma S. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. PLoS Pathog. 2023 05; 19(5):e1011409. PMID: 37200377.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Dean LS, Devendra G, Jiyarom B, Subia N, Tallquist MD, Nerurkar VR, Chang SP, Chow DC, Shikuma CM, Park J. Corrigendum: Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequelae of SARS-CoV-2 infection. Front Immunol. 2023; 14:1209624. PMID: 37187732.
      Citations:    Fields:    
    7. Park J, Dean LS, Jiyarom B, Gangcuangco LM, Shah P, Awamura T, Ching LL, Nerurkar VR, Chow DC, Igno F, Shikuma CM, Devendra G. Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals. Front Immunol. 2023; 14:1151780. PMID: 37077911.
      Citations: 8     Fields:    Translation:HumansCells
    8. Dean LS, Devendra G, Jiyarom B, Subia N, Tallquist MD, Nerurkar VR, Chang SP, Chow DC, Shikuma CM, Park J. Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequalae of SARS-CoV-2 infection. Front Immunol. 2022; 13:1076724. PMID: 36591237.
      Citations:    Fields:    Translation:HumansCells
    9. Maison DP, Cleveland SB, Nerurkar VR. Genomic analysis of SARS-CoV-2 variants of concern circulating in Hawai'i to facilitate public-health policies. PLoS One. 2022; 17(12):e0278287. PMID: 36454775.
      Citations:    Fields:    Translation:HumansCells
    10. Dai YC, Lin YC, Ching LL, Tseng AC, Qin Y, Nerurkar VR, Wang WK. Identification of severe acute respiratory syndrome coronavirus 2 breakthrough infections by anti-nucleocapsid antibody among fully vaccinated non-healthcare workers during the transition from the delta to omicron wave. Front Med (Lausanne). 2022; 9:1019490. PMID: 36523785.
      Citations:    
    11. Maison DP, Ching LL, Cleveland SB, Tseng AC, Nakano E, Shikuma CM, Nerurkar VR. Dynamic SARS-CoV-2 emergence algorithm for rationally-designed logical next-generation vaccines. Commun Biol. 2022 10 10; 5(1):1081. PMID: 36217024.
      Citations:    
    12. Giannakopoulos S, Strange DP, Jiyarom B, Abdelaal O, Bradshaw AW, Nerurkar VR, Ward MA, Bakse J, Yap J, Vanapruks S, Boisvert W, Tallquist MD, Shikuma C, Sadri-Ardekani H, Clapp P, Murphy S, Verma S. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. bioRxiv. 2022 Sep 22. PMID: 36172118.
      Citations:    
    13. Ching LL, Tseng AC, Nakano E, Salomon RC, Wang WK, Shikuma C, Nerurkar VR. COVID-19 vaccination and booster induced authentic-virus neutralizing antibody response is superior to SARS-CoV-2 natural infection induced response. J Clin Virol. 2022 07; 152:105185. PMID: 35605371.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    14. Tsai WY, Ching LL, Hsieh SC, Melish ME, Nerurkar VR, Wang WK. A real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter. Emerg Microbes Infect. 2021 Dec; 10(1):894-904. PMID: 33929934.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Maison DP, Ching LL, Cleveland SB, Tseng AC, Nakano E, Shikuma CM, Nerurkar VR. Algorithm for the Quantitation of Variants of Concern for Rationally Designed Vaccines Based on the Isolation of SARS-CoV-2 Hawai'i Lineage B.1.243. bioRxiv. 2021 Aug 19. PMID: 34751271.
      Citations:    
    16. Maison DP, Cleveland SB, Nerurkar VR. Genomic Analysis of SARS-CoV-2 Variants of Concern Circulating in Hawai'i to Facilitate Public-Health Policies. Res Sq. 2021 Jul 29. PMID: 33821261.
      Citations:    
    17. Chirmule N, Nair P, Desai B, Khare R, Nerurkar V, Gaur A. Predicting the severity of disease progression in COVID-19 at the individual and population level: A mathematical model. medRxiv. 2021 Apr 07. PMID: 33851191.
      Citations:    
    18. Maison DP, Ching LL, Shikuma CM, Nerurkar VR. Genetic Characteristics and Phylogeny of 969-bp S Gene Sequence of SARS-CoV-2 from Hawai'i Reveals the Worldwide Emerging P681H Mutation. Hawaii J Health Soc Welf. 2021 03 01; 80(3):52-61. PMID: 33718878.
      Citations: 26     Fields:    Translation:HumansCells
    19. Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Potential Dual Role of West Nile Virus NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication. Viruses. 2021 01 31; 13(2). PMID: 33572517.
      Citations: 1     Fields:    Translation:HumansCells
    20. Maison DP, Ching LL, Shikuma CM, Nerurkar VR. Genetic Characteristics and Phylogeny of 969-bp S Gene Sequence of SARS-CoV-2 from Hawaii Reveals the Worldwide Emerging P681H Mutation. bioRxiv. 2021 Jan 07. PMID: 33442699.
      Citations:    
    21. Chirmule N, Khare R, Nair P, Desai B, Nerurkar V, Gaur A. Predicting the Severity of Disease Progression in COVID-19 at the Individual and Population Level: A Mathematical Model. Clin Exp Pharmacol. 2021; 11(5). PMID: 34367726.
      Citations:    
    22. Ching LL, Nerurkar VR, Lim E, Shohet RV, Melish ME, Bratincsak A. Elevated Levels of Pentraxin 3 Correlate With Neutrophilia and Coronary Artery Dilation During Acute Kawasaki Disease. Front Pediatr. 2020; 8:295. PMID: 32670996.
      Citations:    
    23. Gallo LG, Martinez-Cajas J, Peixoto HM, Pereira ACEDS, Carter JE, McKeown S, Schaub B, Ventura CV, de Fran?a GVA, Pomar L, Ventura LO, Nerurkar VR, de Ara?jo WN, Velez MP. Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis. BMC Public Health. 2020 Jun 01; 20(1):827. PMID: 32487247.
      Citations: 9     Fields:    Translation:HumansCells
    24. Ching L, Chang SP, Nerurkar VR. COVID-19 Special Column: Principles Behind the Technology for Detecting SARS-CoV-2, the Cause of COVID-19. Hawaii J Health Soc Welf. 2020 05 01; 79(5):136-142. PMID: 32432217.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    25. Kaufusi PH, Tseng AC, Kelley JF, Nerurkar VR. Selective Reactivity of Anti-Japanese Encephalitis Virus NS4B Antibody Towards Different Flaviviruses. Viruses. 2020 02 14; 12(2). PMID: 32075019.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Tyson J, Tsai WY, Tsai JJ, M?ssg?rd L, Stramer SL, Lehrer AT, Nerurkar VR, Wang WK. A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections. PLoS Negl Trop Dis. 2019 08; 13(8):e0007649. PMID: 31442225.
      Citations: 14     Fields:    Translation:Humans
    27. Haun BK, Kamara V, Dweh AS, Garalde-Machida K, Forkay SSE, Takaaze M, Namekar M, Wong TAS, Bell-Gam Woto AER, Humphreys P, Weeks OI, Fallah MP, Berestecky JM, Nerurkar VR, Lehrer AT. Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: A preliminary report. PLoS Negl Trop Dis. 2019 07; 13(7):e0007614. PMID: 31329600.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Nerurkar PV, Orias D, Soares N, Kumar M, Nerurkar VR. Momordica charantia (bitter melon) modulates adipose tissue inflammasome gene expression and adipose-gut inflammatory cross talk in high-fat diet (HFD)-fed mice. J Nutr Biochem. 2019 06; 68:16-32. PMID: 31005847.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Mfuh KO, Achonduh-Atijegbe OA, Bekindaka ON, Esemu LF, Mbakop CD, Gandhi K, Leke RGF, Taylor DW, Nerurkar VR. A comparison of thick-film microscopy, rapid diagnostic test, and polymerase chain reaction for accurate diagnosis of Plasmodium falciparum malaria. Malar J. 2019 Mar 12; 18(1):73. PMID: 30866947.
      Citations: 32     Fields:    Translation:HumansAnimals
    30. Azouz F, Arora K, Krause K, Nerurkar VR, Kumar M. Integrated MicroRNA and mRNA Profiling in Zika Virus-Infected Neurons. Viruses. 2019 02 16; 11(2). PMID: 30781519.
      Citations: 26     Fields:    Translation:AnimalsCells
    31. Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M. Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Front Microbiol. 2019; 10:259. PMID: 30814992.
      Citations:    
    32. Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S. Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis". J Virol. 2018 08 01; 92(15). PMID: 30018145.
      Citations: 1     Fields:    
    33. Lloyd YM, Esemu LF, Antallan J, Thomas B, Tassi Yunga S, Obase B, Christine N, Leke RGF, Culleton R, Mfuh KO, Nerurkar VR, Taylor DW. PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers. Trop Med Health. 2018; 46:22. PMID: 29977122.
      Citations:    
    34. To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere. 2018 Jan-Feb; 3(1). PMID: 29359186.
      Citations: 30     Fields:    
    35. Bratincsak A, Limm-Chan BN, Nerurkar VR, Ching LL, Reddy VD, Lim E, Shohet RV, Melish ME. Study design and rationale to assess Doxycycline Efficacy in preventing coronary Artery Lesions in children with Kawasaki disease (DEAL trial) - A phase II clinical trial. Contemp Clin Trials. 2018 02; 65:33-38. PMID: 29313803.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    36. Mfuh KO, Tassi Yunga S, Esemu LF, Bekindaka ON, Yonga J, Djontu JC, Mbakop CD, Taylor DW, Nerurkar VR, Leke RGF. Detection of Plasmodium falciparum DNA in saliva samples stored at room temperature: potential for a non-invasive saliva-based diagnostic test for malaria. Malar J. 2017 10 27; 16(1):434. PMID: 29078786.
      Citations: 13     Fields:    Translation:HumansAnimals
    37. Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR. A guinea pig model of Zika virus infection. Virol J. 2017 04 11; 14(1):75. PMID: 28399888.
      Citations: 44     Fields:    Translation:AnimalsCells
    38. Yanagihara R, Nerurkar VR, Hui G, Jacobs GA. Medical School Hotline: Pacific Center for Emerging Infectious Diseases Research. Hawaii J Med Public Health. 2017 01; 76(1):23-26. PMID: 28090400.
      Citations: 1     Fields:    Translation:Humans
    39. Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerurkar VR. Prevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012. PLoS Negl Trop Dis. 2016 12; 10(12):e0005262. PMID: 27997547.
      Citations: 9     Fields:    Translation:HumansCells
    40. Achonduh-Atijegbe OA, Mfuh KO, Mbange AH, Chedjou JP, Taylor DW, Nerurkar VR, Mbacham WF, Leke R. Prevalence of malaria, typhoid, toxoplasmosis and rubella among febrile children in Cameroon. BMC Infect Dis. 2016 11 08; 16(1):658. PMID: 27825318.
      Citations: 14     Fields:    Translation:HumansAnimals
    41. Kumar M, Belcaid M, Nerurkar VR. Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis. Sci Rep. 2016 05 23; 6:26350. PMID: 27211830.
      Citations: 28     Fields:    Translation:AnimalsCells
    42. Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, Melish ME. Clinical and Imaging Findings in an Infant With Zika Embryopathy. Clin Infect Dis. 2016 09 15; 63(6):805-11. PMID: 27193747.
      Citations: 32     Fields:    Translation:Humans
    43. Kaufusi PH, Tseng A, Nerurkar VR. Functional Analysis of West Nile Virus Proteins in Human Cells. Methods Mol Biol. 2016; 1435:45-60. PMID: 27188549.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    44. Kumar M, Nerurkar VR. In Vitro and In Vivo Blood-Brain Barrier Models to Study West Nile Virus Pathogenesis. Methods Mol Biol. 2016; 1435:103-13. PMID: 27188553.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    45. Kumar M, Roe K, O'Connell M, Nerurkar VR. Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain. J Neuroinflammation. 2015 Sep 22; 12:178. PMID: 26392176.
      Citations: 8     Fields:    Translation:AnimalsCells
    46. Ton TG, Gladding SP, Zunt JR, John C, Nerurkar VR, Moyer CA, Hobbs N, McCoy M, Kolars JC. The development and implementation of a competency-based curriculum for training in global health research. Am J Trop Med Hyg. 2015 Jan; 92(1):163-71. PMID: 25371189.
      Citations: 16     Fields:    
    47. Hsieh SC, Wu YC, Zou G, Nerurkar VR, Shi PY, Wang WK. Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry. J Biol Chem. 2014 Nov 28; 289(48):33149-60. PMID: 25326389.
      Citations: 25     Fields:    Translation:HumansCells
    48. Hsieh SC, Tsai WY, Nerurkar VR, Wang WK. Characterization of the ectodomain of the envelope protein of dengue virus type 4: expression, membrane association, secretion and particle formation in the absence of precursor membrane protein. PLoS One. 2014; 9(6):e100641. PMID: 24950216.
      Citations: 5     Fields:    Translation:HumansCells
    49. Kumar M, O'Connell M, Namekar M, Nerurkar VR. Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain. Viruses. 2014 Jun 06; 6(6):2328-39. PMID: 24915459.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    50. Kumar M, Roe K, Nerurkar PV, Orillo B, Thompson KS, Verma S, Nerurkar VR. Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus. J Neuroinflammation. 2014 Apr 21; 11:80. PMID: 24750819.
      Citations: 41     Fields:    Translation:AnimalsCells
    51. Kumar M, Nerurkar VR. Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus. Virology. 2014 Mar; 452-453:143-51. PMID: 24606691.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    52. Kaufusi PH, Kelley JF, Yanagihara R, Nerurkar VR. Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B. PLoS One. 2014; 9(1):e84040. PMID: 24465392.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    53. Wu C, Nerurkar VR, Lu Y. New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3. Retrovirology. 2013 Oct 24; 10:112. PMID: 24156557.
      Citations: 1     Fields:    Translation:HumansCells
    54. Namekar M, Ellis EM, O'Connell M, Elm J, Gurary A, Park SY, Imrie A, Nerurkar VR. Evaluation of a new commercially available immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of dengue virus infection. J Clin Microbiol. 2013 Sep; 51(9):3102-6. PMID: 23824771.
      Citations: 19     Fields:    Translation:HumansCells
    55. Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S. Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J Virol. 2013 Apr; 87(7):3655-67. PMID: 23302887.
      Citations: 65     Fields:    Translation:AnimalsCells
    56. Tsai WY, Hsieh SC, Lai CY, Lin HE, Nerurkar VR, Wang WK. C-terminal helical domains of dengue virus type 4 E protein affect the expression/stability of prM protein and conformation of prM and E proteins. PLoS One. 2012; 7(12):e52600. PMID: 23300717.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    57. Namekar M, Kumar M, O'Connell M, Nerurkar VR. Effect of serum heat-inactivation and dilution on detection of anti-WNV antibodies in mice by West Nile virus E-protein microsphere immunoassay. PLoS One. 2012; 7(9):e45851. PMID: 23049879.
      Citations: 28     Fields:    Translation:AnimalsCells
    58. Kumar M, Roe K, Nerurkar PV, Namekar M, Orillo B, Verma S, Nerurkar VR. Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. PLoS One. 2012; 7(8):e44682. PMID: 22953001.
      Citations: 35     Fields:    Translation:AnimalsCells
    59. Roe K, Kumar M, Lum S, Orillo B, Nerurkar VR, Verma S. West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases. J Gen Virol. 2012 Jun; 93(Pt 6):1193-1203. PMID: 22398316.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    60. Kelley JF, Kaufusi PH, Nerurkar VR. Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability. Virology. 2012 Jan 20; 422(2):326-37. PMID: 22129847.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    61. Nerurkar PV, Nishioka A, Eck PO, Johns LM, Volper E, Nerurkar VR. Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese mice. Br J Nutr. 2012 Jul; 108(2):218-228. PMID: 22011624.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    62. Kelley JF, Kaufusi PH, Volper EM, Nerurkar VR. Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines. Virology. 2011 Sep 15; 418(1):27-39. PMID: 21810535.
      Citations: 13     Fields:    Translation:HumansCells
    63. Snee LS, Nerurkar VR, Dooley DA, Efird JT, Shovic AC, Nerurkar PV. Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management. Nutr J. 2011 Jul 28; 10:78. PMID: 21794176.
      Citations: 8     Fields:    Translation:HumansAnimals
    64. Nerurkar PV, Johns LM, Buesa LM, Kipyakwai G, Volper E, Sato R, Shah P, Feher D, Williams PG, Nerurkar VR. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation. 2011 Jun 03; 8:64. PMID: 21639917.
      Citations: 55     Fields:    Translation:Animals
    65. Verma S, Kumar M, Nerurkar VR. Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes. J Gen Virol. 2011 Mar; 92(Pt 3):507-15. PMID: 21106803.
      Citations: 20     Fields:    Translation:HumansCells
    66. Kumar M, Verma S, Nerurkar VR. Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death. J Neuroinflammation. 2010 Oct 31; 7:73. PMID: 21034511.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    67. Zhang L, Qi F, Gaudino G, Strianese O, Yang H, Morris P, Pass HI, Nerurkar VR, Bocchetta M, Carbone M. Tissue Tropism of SV40 Transformation of Human Cells: Role of the Viral Regulatory Region and of Cellular Oncogenes. Genes Cancer. 2010 Oct; 1(10):1008-20. PMID: 21779427.
      Citations:    
    68. Chapagain ML, Nerurkar VR. Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier. J Infect Dis. 2010 Jul 15; 202(2):184-91. PMID: 20550458.
      Citations: 62     Fields:    Translation:HumansCells
    69. Nerurkar PV, Lee YK, Nerurkar VR. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med. 2010 Jun 29; 10:34. PMID: 20587058.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    70. Rai MA, Nerurkar VR, Khoja S, Khan S, Yanagihara R, Rehman A, Kazmi SU, Ali SH. Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan. BMC Infect Dis. 2010 Jan 12; 10:7. PMID: 20064274.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    71. Verma S, Kumar M, Gurjav U, Lum S, Nerurkar VR. Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor. Virology. 2010 Feb 05; 397(1):130-8. PMID: 19922973.
      Citations: 76     Fields:    Translation:HumansCells
    72. Lieberman MM, Nerurkar VR, Luo H, Cropp B, Carrion R, de la Garza M, Coller BA, Clements D, Ogata S, Wong T, Martyak T, Weeks-Levy C. Immunogenicity and protective efficacy of a recombinant subunit West Nile virus vaccine in rhesus monkeys. Clin Vaccine Immunol. 2009 Sep; 16(9):1332-7. PMID: 19641099.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    73. Verma S, Lo Y, Chapagain M, Lum S, Kumar M, Gurjav U, Luo H, Nakatsuka A, Nerurkar VR. West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier. Virology. 2009 Mar 15; 385(2):425-33. PMID: 19135695.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    74. Chapagain ML, Sumibcay L, Gurjav U, Kaufusi PH, Kast RE, Nerurkar VR. Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells. J Neurovirol. 2008 Oct; 14(5):448-54. PMID: 18989819.
      Citations: 15     Fields:    Translation:HumansCells
    75. Wu C, Nerurkar VR, Yanagihara R, Lu Y. Effective modifications for improved homologous recombination and high-efficiency generation of recombinant adenovirus-based vectors. J Virol Methods. 2008 Nov; 153(2):120-8. PMID: 18755219.
      Citations: 3     Fields:    Translation:HumansCells
    76. Jarvi SI, Lieberman MM, Hofmeister E, Nerurkar VR, Wong T, Weeks-Levy C. Protective efficacy of a recombinant subunit West Nile virus vaccine in domestic geese (Anser anser). Vaccine. 2008 Oct 03; 26(42):5338-44. PMID: 18723064.
      Citations: 8     Fields:    Translation:AnimalsCells
    77. Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R, Nerurkar VR. In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity. Virol J. 2008 May 31; 5:66. PMID: 18513435.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    78. Yang Y, Wu C, Wu J, Nerurkar VR, Yanagihara R, Lu Y. Inhibition of West Nile Virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells. J Med Virol. 2008 May; 80(5):930-6. PMID: 18360908.
      Citations: 6     Fields:    Translation:HumansCells
    79. Nerurkar PV, Nerurkar VR. Respected Sir(2): magic target for diabetes. Cellscience. 2008 Apr 27; 4(4):82-96. PMID: 20577646.
      Citations:    
    80. Nerurkar PV, Nerurkar VR. Can Sir(2) regulate cancer? Cellscience. 2008 Apr 01; 4(4):50-56. PMID: 19750026.
      Citations:    
    81. Nerurkar PV, Lee YK, Motosue M, Adeli K, Nerurkar VR. Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions. Br J Nutr. 2008 Oct; 100(4):751-9. PMID: 18321395.
      Citations: 18     Fields:    Translation:Animals
    82. Arai S, Bennett SN, Sumibcay L, Cook JA, Song JW, Hope A, Parmenter C, Nerurkar VR, Yates TL, Yanagihara R. Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States. Am J Trop Med Hyg. 2008 Feb; 78(2):348-51. PMID: 18256444.
      Citations: 44     Fields:    Translation:AnimalsCells
    83. Arai S, Song JW, Sumibcay L, Bennett SN, Nerurkar VR, Parmenter C, Cook JA, Yates TL, Yanagihara R. Hantavirus in northern short-tailed shrew, United States. Emerg Infect Dis. 2007 Sep; 13(9):1420-3. PMID: 18252128.
      Citations: 46     Fields:    Translation:AnimalsCells
    84. Co JK, Verma S, Gurjav U, Sumibcay L, Nerurkar VR. Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy. J Infect Dis. 2007 Sep 01; 196(5):712-8. PMID: 17674314.
      Citations: 19     Fields:    Translation:HumansCells
    85. Shiramizu B, Hu N, Frisque RJ, Nerurkar VR. High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. Cell Mol Biol (Noisy-le-grand). 2007 May 15; 53(3):4-12. PMID: 17531143.
      Citations: 7     Fields:    Translation:HumansCells
    86. Chapagain ML, Verma S, Mercier F, Yanagihara R, Nerurkar VR. Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A. Virology. 2007 Jul 20; 364(1):55-63. PMID: 17399760.
      Citations: 37     Fields:    Translation:HumansCells
    87. Rai MA, Warraich HJ, Ali SH, Nerurkar VR. HIV/AIDS in Pakistan: the battle begins. Retrovirology. 2007 Mar 21; 4:22. PMID: 17376244.
      Citations: 16     Fields:    Translation:HumansPHPublic Health
    88. Nerurkar PV, Lee YK, Linden EH, Lim S, Pearson L, Frank J, Nerurkar VR. Lipid lowering effects of Momordica charantia (Bitter Melon) in HIV-1-protease inhibitor-treated human hepatoma cells, HepG2. Br J Pharmacol. 2006 Aug; 148(8):1156-64. PMID: 16847441.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    89. Chapagain ML, Nguyen T, Bui T, Verma S, Nerurkar VR. Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC. Virol J. 2006 Jan 09; 3:3. PMID: 16398941.
      Citations: 14     Fields:    Translation:HumansCells
    90. Zeng L, Planelles V, Sui Z, Gartner S, Maggirwar SB, Dewhurst S, Ye L, Nerurkar VR, Yanagihara R, Lu Y. HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. J Gene Med. 2006 Jan; 8(1):18-28. PMID: 16142830.
      Citations: 11     Fields:    Translation:HumansCells
    91. Verma S, Ziegler K, Ananthula P, Co JK, Frisque RJ, Yanagihara R, Nerurkar VR. JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets. Virology. 2006 Feb 20; 345(2):457-67. PMID: 16297951.
      Citations: 27     Fields:    Translation:HumansCells
    92. Tonry JH, Brown CB, Cropp CB, Co JK, Bennett SN, Nerurkar VR, Kuberski T, Gubler DJ. West Nile virus detection in urine. Emerg Infect Dis. 2005 Aug; 11(8):1294-6. PMID: 16102323.
      Citations: 27     Fields:    Translation:HumansCells
    93. Nerurkar PV, Pearson L, Efird JT, Adeli K, Theriault AG, Nerurkar VR. Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. J Nutr. 2005 Apr; 135(4):702-6. PMID: 15795421.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    94. Lorenzo E, Colon MC, Almodovar S, Maldonado IM, Gonzalez S, Costa SE, Hill MD, Mendoza R, Sepulveda G, Yanagihara R, Nerurkar V, Kumar R, Yamamura Y, Scott WA, Kumar A. Influence of CD4+ T cell counts on viral evolution in HIV-infected individuals undergoing suppressive HAART. Virology. 2004 Dec 05; 330(1):116-26. PMID: 15527839.
      Citations: 5     Fields:    Translation:HumansCells
    95. Ziegler K, Bui T, Frisque RJ, Grandinetti A, Nerurkar VR. A rapid in vitro polyomavirus DNA replication assay. J Virol Methods. 2004 Dec 01; 122(1):123-7. PMID: 15488630.
      Citations: 41     Fields:    Translation:Cells
    96. Hoffmann PR, Woodrow RJ, Calimlim PS, Sciulli R, Effler PV, Miyamoto V, Imrie A, Yanagihara R, Nerurkar VR. West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools. J Med Entomol. 2004 Jul; 41(4):731-5. PMID: 15311468.
      Citations: 9     Fields:    Translation:AnimalsCells
    97. Chua PK, Melish ME, Yu Q, Yanagihara R, Yamamoto KS, Nerurkar VR. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin Diagn Lab Immunol. 2003 Mar; 10(2):308-14. PMID: 12626459.
      Citations: 18     Fields:    Translation:Humans
    98. Shiramizu B, Yu Q, Hu N, Yanagihara R, Nerurkar VR. Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol. 2002 Dec; 19(8):543-51. PMID: 12487829.
      Citations: 9     Fields:    Translation:HumansCells
    99. Yanagihara R, Nerurkar VR, Scheirich I, Agostini HT, Mgone CS, Cui X, Jobes DV, Cubitt CL, Ryschkewitsch CF, Hrdy DB, Friedlaender JS, Stoner GL. JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements. Hum Biol. 2002 Jun; 74(3):473-88. PMID: 12180767.
      Citations: 6     Fields:    Translation:HumansCells
    100. Yu Q, Shiramizu B, Nerurkar VR, Hu N, Shikuma CM, Melish ME, Cascio K, Imrie A, Lu Y, Yanagihara R. TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration. J Med Virol. 2002 Feb; 66(2):276-84. PMID: 11782940.
      Citations: 4     Fields:    Translation:HumansCells
    101. Nerurkar PV, Shikuma CM, Nerurkar VR. Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-associated lipodystrophy. Clin Biochem. 2001 Oct; 34(7):519-29. PMID: 11738387.
      Citations: 2     Fields:    Translation:HumansCells
    102. Yu Q, Lu Y, Nerurkar VR, Yanagihara R. Studies on the Turtle Tumor Susceptibility Gene TSG101: Full-Length cDNA Sequence, Genomic Structural Analysis, and Role in Green Turtle Fibropapilloma. J Aquat Anim Health. 2000 Dec; 12(4):274-282. PMID: 36530584.
      Citations:    Fields:    
    103. Lu Y, Yu Q, Zamzow JP, Wang Y, Losey GS, Balazs GH, Nerurkar VR, Yanagihara R. Detection of Green Turtle Herpesviral Sequence in Saddleback Wrasse Thalassoma duperrey: A Possible Mode of Transmission of Green Turtle Fibropapilloma. J Aquat Anim Health. 2000 Mar; 12(1):58-63. PMID: 28880781.
      Citations: 6     Fields:    
    104. Nerurkar VR, Woodward CL, Nguyen HT, DeWolfe Miller F, Tashima LT, Zalles-Ganley A, Chua PK, Peterson JE, Chi PK, Hoang LT, Detels R, Yanagihara R. Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam. Int J Infect Dis. 1999; 3(4):181-5. PMID: 10575145.
      Citations: 2     Fields:    Translation:HumansCells
    105. Lu Y, Nerurkar VR, Dashwood WM, Woodward CL, Ablan S, Shikuma CM, Grandinetti A, Chang H, Nguyen HT, Wu Z, Yamamura Y, Boto WO, Merriwether A, Kurata T, Detels R, Yanagihara R. Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders. Int J Infect Dis. 1999; 3(4):186-91. PMID: 10575146.
      Citations: 11     Fields:    Translation:HumansCells
    106. Nerurkar VR, Chua PK, Hoffmann PR, Dashwood WM, Shikuma CM, Yanagihara R. High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission. J Med Virol. 1998 Oct; 56(2):123-7. PMID: 9746067.
      Citations: 12     Fields:    Translation:HumansCells
    107. Nerurkar VR, Wu Z, Dashwood WM, Woodward CL, Zhang M, Detels R, Yanagihara R. Complete nef gene sequence of HIV type 1 subtype B' from professional plasma donors in the People's Republic of China. AIDS Res Hum Retroviruses. 1998 Mar 20; 14(5):461-4. PMID: 9546806.
      Citations: 1     Fields:    Translation:HumansCells
    108. Wakayama I, Song KJ, Nerurkar VR, Yoshida S, Garruto RM. Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum. Brain Res. 1997 Feb 14; 748(1-2):237-40. PMID: 9067468.
      Citations: 5     Fields:    Translation:AnimalsCells
    109. Wakayama I, Nerurkar VR, Strong MJ, Garruto RM. Comparative study of chronic aluminum-induced neurofilamentous aggregates with intracytoplasmic inclusions of amyotrophic lateral sclerosis. Acta Neuropathol. 1996 Dec; 92(6):545-54. PMID: 8960311.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    110. Kordek R, Nerurkar VR, Liberski PP, Isaacson S, Yanagihara R, Gajdusek DC. Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9754-8. PMID: 8790403.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    111. Nerurkar VR, Nguyen HT, Dashwood WM, Hoffmann PR, Yin C, Morens DM, Kaplan AH, Detels R, Yanagihara R. HIV type 1 subtype E in commercial sex workers and injection drug users in southern Vietnam. AIDS Res Hum Retroviruses. 1996 Jun 10; 12(9):841-3. PMID: 8738437.
      Citations: 2     Fields:    Translation:HumansCells
    112. Liberski PP, Nerurkar VR, Yanagihara R, Gajdusek DC. Tumor necrosis factor alpha (TNF-alpha) is involved in the pathogenesis of the panencephalopathic type of Creutzfeldt-Jakob disease. Mol Chem Neuropathol. 1995 Feb-Apr; 24(2-3):223-5. PMID: 7632323.
      Citations: 1     Fields:    Translation:AnimalsCells
    113. Switzer WM, Owen SM, Pieniazek DA, Nerurkar VR, Duenas-Barajas E, Heneine W, Lal RB. Molecular analysis of human T-cell lymphotropic virus type II from Wayuu Indians of Colombia demonstrates two subtypes of HTLV-IIb. Virus Genes. 1995; 10(2):153-62. PMID: 8560775.
      Citations: 10     Fields:    Translation:HumansCells
    114. Nerurkar VR, Song JW, Song KJ, Nagle JW, Hjelle B, Jenison S, Yanagihara R. Genetic evidence for a hantavirus enzootic in deer mice (Peromyscus maniculatus) captured a decade before the recognition of hantavirus pulmonary syndrome. Virology. 1994 Nov 01; 204(2):563-8. PMID: 7941323.
      Citations: 18     Fields:    Translation:AnimalsCells
    115. Liberski PP, Yanagihara R, Nerurkar V, Gajdusek DC. Further ultrastructural studies of lesions produced in the optic nerve by tumor necrosis factor alpha (TNF-alpha): a comparison with experimental Creutzfeldt-Jakob disease. Acta Neurobiol Exp (Wars). 1994; 54(3):209-18. PMID: 7817836.
      Citations:    Fields:    Translation:HumansAnimals
    116. Nerurkar VR, Song KJ, Gajdusek DC, Yanagihara R. Genetically distinct hantavirus in deer mice. Lancet. 1993 Oct 23; 342(8878):1058-9. PMID: 8105294.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    117. Joshi SV, Vaidya SG, Nerurkar VR, Soman C. Treatment of gamma radiation-induced transplanted leukemia in ICRC mice by liposomally encapsulated 5-fluoro uracil. Leuk Res. 1993 Jul; 17(7):601-7. PMID: 8326742.
      Citations:    Fields:    Translation:Animals
    118. Nerurkar VR, Wakayama I, Rowe T, Yanagihara R, Garruto RM. Preliminary observations on the in vitro toxicity of N-butylbenzenesulfonamide: a newly discovered neurotoxin. Ann N Y Acad Sci. 1993 May 28; 679:280-7. PMID: 8512189.
      Citations: 2     Fields:    Translation:AnimalsCells
    119. Wakayama I, Nerurkar VR, Garruto RM. Immunocytochemical and ultrastructural evidence of dendritic degeneration in motor neurons of aluminum-intoxicated rabbits. Acta Neuropathol. 1993; 85(2):122-8. PMID: 8442404.
      Citations: 2     Fields:    Translation:AnimalsCells
    120. Nerurkar VA, Yanagihara R. Specificity of an oligonucleotide primer pair and of a single-base substitution in the amplification and detection of env gene sequences of HTLV-I variants from Papua New Guinea and the Solomon Islands. AIDS Res Hum Retroviruses. 1992 Jul; 8(7):1199-200. PMID: 1520532.
      Citations: 1     Fields:    Translation:HumansCells
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