"JC Virus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.
Descriptor ID |
D007577
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MeSH Number(s) |
B04.280.210.620.615.400 B04.613.204.670.615.400
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Concept/Terms |
JC Virus- JC Virus
- Polyomavirus, JC
- JC polyomavirus
- Polyomavirus hominis 2
- John Cunningham Virus
- Virus, John Cunningham
- Human Polyomavirus JC
- Polyomavirus JC, Human
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Below are MeSH descriptors whose meaning is more general than "JC Virus".
Below are MeSH descriptors whose meaning is more specific than "JC Virus".
This graph shows the total number of publications written about "JC Virus" by people in this website by year, and whether "JC Virus" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
1998 | 0 | 1 | 1 |
2000 | 1 | 0 | 1 |
2001 | 3 | 0 | 3 |
2002 | 1 | 0 | 1 |
2003 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2007 | 3 | 0 | 3 |
2008 | 1 | 0 | 1 |
2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "JC Virus" by people in Profiles.
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Chapagain ML, Nerurkar VR. Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier. J Infect Dis. 2010 Jul 15; 202(2):184-91.
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Chapagain ML, Sumibcay L, Gurjav U, Kaufusi PH, Kast RE, Nerurkar VR. Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells. J Neurovirol. 2008 Oct; 14(5):448-54.
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Co JK, Verma S, Gurjav U, Sumibcay L, Nerurkar VR. Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy. J Infect Dis. 2007 Sep 01; 196(5):712-8.
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Shiramizu B, Hu N, Frisque RJ, Nerurkar VR. High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies. Cell Mol Biol (Noisy-le-grand). 2007 May 15; 53(3):4-12.
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Chapagain ML, Verma S, Mercier F, Yanagihara R, Nerurkar VR. Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A. Virology. 2007 Jul 20; 364(1):55-63.
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Chapagain ML, Nguyen T, Bui T, Verma S, Nerurkar VR. Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC. Virol J. 2006 Jan 09; 3:3.
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Verma S, Ziegler K, Ananthula P, Co JK, Frisque RJ, Yanagihara R, Nerurkar VR. JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets. Virology. 2006 Feb 20; 345(2):457-67.
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Carbone M, Burck C, Rdzanek M, Rudzinski J, Cutrone R, Bocchetta M. Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformation. Cancer Res. 2003 Oct 01; 63(19):6125-9.
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Yanagihara R, Nerurkar VR, Scheirich I, Agostini HT, Mgone CS, Cui X, Jobes DV, Cubitt CL, Ryschkewitsch CF, Hrdy DB, Friedlaender JS, Stoner GL. JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements. Hum Biol. 2002 Jun; 74(3):473-88.
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Cubitt CL, Cui X, Agostini HT, Nerurkar VR, Scheirich I, Yanagihara R, Ryschkewitsch CF, Stoner GL. Predicted amino acid sequences for 100 JCV strains. J Neurovirol. 2001 Aug; 7(4):339-44.