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Wei-Kung Wang, M.D., Sc.D.

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921667
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    Collapse Research 
    Collapse research activities and funding
    R01AI110769     (WANG, WEI-KUNG)Apr 1, 2014 - Mar 31, 2020
    NIH
    Mature virus-like particles as a new strategy for dengue virus vaccines
    Role: Principal Investigator
    P30GM114737     (YANAGIHARA, RICHARD)Jul 1, 2015 - Jun 30, 2021
    NIH
    Pacific Center for Emerging Infectious Diseases Research
    Role: Co-Principal Investigator
    R21AI135292     (WANG, WEI-KUNG)Jun 6, 2018 - May 31, 2021
    NIH
    Serodiagnostic tests to distinguish Zika virus from other flaviviruses
    Role: Principal Investigator
    R01AI149502     (WANG, WEI-KUNG)Jun 5, 2020 - May 31, 2024
    NIH
    Multiplex Serodiagnostic Assays for Pathogenic Arboviruses in Brazil
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Du Y, Li Q, Zhou G, Cai Z, Man Q, Wang WC. Early-life perfluorooctanoic acid exposure disrupts the function of dopamine transporter protein with glycosylation changes implicating the links between decreased dopamine levels and disruptive behaviors in larval zebrafish. Sci Total Environ. 2024 Mar 20; 917:170408. PMID: 38281643.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Chen GH, Dai YC, Hsieh SC, Tsai JJ, Sy AK, Jiz M, Pedroso C, Brites C, Netto EM, Kanki PJ, Saunders DRD, Vanlandingham DL, Higgs S, Huang YS, Wang WK. Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions. Emerg Microbes Infect. 2024 Dec; 13(1):2301666. PMID: 38163752.
      Citations:    Fields:    Translation:AnimalsCells
    3. Du Y, Chen C, Zhou G, Cai Z, Man Q, Liu B, Wang WC. Perfluorooctanoic acid disrupts thyroid-specific genes expression and regulation via the TSH-TSHR signaling pathway in thyroid cells. Environ Res. 2023 Dec 15; 239(Pt 1):117372. PMID: 37827365.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Dai YC, Sy AK, Jiz M, Tsai JJ, Bato J, Quino?es MA, Reyes MAJ, Wang WK. Identification of prior dengue-na?ve Dengvaxia recipients with an increased risk for symptomatic dengue during fever surveillance in the Philippines. Front Immunol. 2023; 14:1202055. PMID: 37554332.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Dai YC, Lin YC, Ching LL, Tsai JJ, Ishikawa K, Tsai WY, Chen JJ, Nerurkar VR, Wang WK. Determining the Time of Booster Dose Based on the Half-Life and Neutralization Titers against SARS-CoV-2 Variants of Concern in Fully Vaccinated Individuals. Microbiol Spectr. 2023 08 17; 11(4):e0408122. PMID: 37428104.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    6. Ching LL, Tseng AC, Nakano E, Salomon RC, Wang WK, Shikuma C, Nerurkar VR. COVID-19 vaccination and booster induced authentic-virus neutralizing antibody response is superior to SARS-CoV-2 natural infection induced response. J Clin Virol. 2022 07; 152:105185. PMID: 35605371.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    7. Hsieh SC, Tsai WY, Wang WK. Obtention of Dengue Virus Membrane Proteins and Role for Virus Assembly. Methods Mol Biol. 2022; 2409:63-76. PMID: 34709636.
      Citations:    Fields:    Translation:HumansCells
    8. Tsai WY, Ching LL, Hsieh SC, Melish ME, Nerurkar VR, Wang WK. A real-time and high-throughput neutralization test based on SARS-CoV-2 pseudovirus containing monomeric infrared fluorescent protein as reporter. Emerg Microbes Infect. 2021 Dec; 10(1):894-904. PMID: 33929934.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Hsieh SC, Tsai WY, Tsai JJ, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK. Identification of Anti-Premembrane Antibody as a Serocomplex-Specific Marker To Discriminate Zika, Dengue, and West Nile Virus Infections. J Virol. 2021 09 09; 95(19):e0061921. PMID: 34232731.
      Citations: 2     Fields:    Translation:HumansCells
    10. Cao J, Wang W, Zhao Z, Liu X, Li QX. Genome, metabolic pathways and characteristics of cometabolism of dibenzothiophene and the biodiesel byproduct glycerol in Paraburkholderia sp. C3. Bioresour Technol. 2021 Apr; 326:124699. PMID: 33535150.
      Citations: 1     Fields:    
    11. Tsai WY, Driesse K, Tsai JJ, Hsieh SC, Sznajder Granat R, Jenkins O, Chang GJ, Wang WK. Enzyme-linked immunosorbent assays using virus-like particles containing mutations of conserved residues on envelope protein can distinguish three flavivirus infections. Emerg Microbes Infect. 2020 Dec; 9(1):1722-1732. PMID: 32684139.
      Citations: 6     Fields:    Translation:HumansCells
    12. Tyson J, Tsai WY, Tsai JJ, M?ssg?rd L, Stramer SL, Lehrer AT, Nerurkar VR, Wang WK. A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections. PLoS Negl Trop Dis. 2019 08; 13(8):e0007649. PMID: 31442225.
      Citations: 14     Fields:    Translation:Humans
    13. Tyson J, Tsai WY, Tsai JJ, Brites C, M?ssg?rd L, Ha Youn H, Pedroso C, Drexler JF, Stramer SL, Balmaseda A, Harris E, Wang WK. Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections. J Clin Microbiol. 2019 02; 57(2). PMID: 30429254.
      Citations: 17     Fields:    Translation:HumansCells
    14. Tsai WY, Chen HL, Tsai JJ, Dejnirattisai W, Jumnainsong A, Mongkolsapaya J, Screaton G, Crowe JE, Wang WK. Potent Neutralizing Human Monoclonal Antibodies Preferentially Target Mature Dengue Virus Particles: Implication for Novel Strategy for Dengue Vaccine. J Virol. 2018 12 01; 92(23). PMID: 30185598.
      Citations: 18     Fields:    Translation:HumansCells
    15. Wang WK, Gubler DJ. Potential Point-of-Care Testing for Dengue Virus in the Field. J Clin Microbiol. 2018 05; 56(5). PMID: 29514934.
      Citations: 7     Fields:    Translation:HumansCells
    16. Tsai WY, Youn HH, Brites C, Tsai JJ, Tyson J, Pedroso C, Drexler JF, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK. Distinguishing Secondary Dengue Virus Infection From Zika Virus Infection With Previous Dengue by a Combination of 3 Simple Serological Tests. Clin Infect Dis. 2017 Nov 13; 65(11):1829-1836. PMID: 29020159.
      Citations: 39     Fields:    Translation:HumansCells
    17. Tsai WY, Lin HE, Wang WK. Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development. Front Microbiol. 2017; 8:1372. PMID: 28775720.
      Citations:    
    18. Hsieh SC, Wu YC, Zou G, Nerurkar VR, Shi PY, Wang WK. Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry. J Biol Chem. 2014 Nov 28; 289(48):33149-60. PMID: 25326389.
      Citations: 25     Fields:    Translation:HumansCells
    19. Hsieh SC, Tsai WY, Nerurkar VR, Wang WK. Characterization of the ectodomain of the envelope protein of dengue virus type 4: expression, membrane association, secretion and particle formation in the absence of precursor membrane protein. PLoS One. 2014; 9(6):e100641. PMID: 24950216.
      Citations: 5     Fields:    Translation:HumansCells
    20. Lai CY, Williams KL, Wu YC, Knight S, Balmaseda A, Harris E, Wang WK. Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases. PLoS Negl Trop Dis. 2013; 7(9):e2451. PMID: 24069496.
      Citations: 44     Fields:    Translation:HumansCells
    21. Tsai WY, Lai CY, Wu YC, Lin HE, Edwards C, Jumnainsong A, Kliks S, Halstead S, Mongkolsapaya J, Screaton GR, Wang WK. High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection. J Virol. 2013 Dec; 87(23):12562-75. PMID: 24027331.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    22. Tsai WY, Hsieh SC, Lai CY, Lin HE, Nerurkar VR, Wang WK. C-terminal helical domains of dengue virus type 4 E protein affect the expression/stability of prM protein and conformation of prM and E proteins. PLoS One. 2012; 7(12):e52600. PMID: 23300717.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
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