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Axel T Lehrer

TitleProf. Dr. rer. nat.
Faculty RankProfessor
InstitutionUniversity of Hawaii at Manoa
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921614
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    Collapse Research 
    Collapse research activities and funding
    R43AI055225     (LEHRER, AXEL T)Jul 1, 2004 - Mar 31, 2007
    NIH
    Recombinant Subunit Vaccine for Tick-Borne Encephalitis
    Role: Principal Investigator
    R43AI066616     (LEHRER, AXEL T)Jun 15, 2007 - Nov 30, 2009
    NIH
    Development of a Recombinant Subunit Ebola Vaccine
    Role: Principal Investigator
    R01AI119185     (LEHRER, AXEL T)Aug 28, 2015 - Jul 31, 2021
    NIH
    Defining a Protective Ebola Vaccine in Non-Human Primates
    Role: Principal Investigator
    R01AI132323     (LEHRER, AXEL T)Jun 20, 2017 - May 31, 2022
    NIH
    Preclinical Development of a Thermostable Trivalent Filovirus Vaccine
    Role: Principal Investigator
    U01GH002256     (LEHRER, AXEL T)Sep 30, 2019 - Sep 29, 2024
    NIH
    Epidemiology and Immunity to Ebola Virus and Other Emerging Viral Infections in Liberia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mayerlen LI, Wong TAS, To A, Smith O, Chuang E, Donini O, Lehrer AT. Thermostable bivalent & trivalent filovirus vaccines from insect cells: potency demonstrated after 3?months and 2?years. Vaccine. 2025 Oct 03; 64:127684. PMID: 40902221.
      Citations:    Fields:    
    2. G?bel S, Mayerlen L, Eiser IY, Fichtmueller L, Clements D, Reichl U, Genzel Y, Lehrer A. Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using Drosophila S2 Cells. Eng Life Sci. 2025 May; 25(5):e70022. PMID: 40391203.
      Citations:    
    3. Merritt S, Halbrook M, Kompany JP, Chandrasekaran P, Smith OA, Hoff NA, Tambu M, Martin SA, Wong TA, Jarra A, Barrall AL, Musene K, Beya M, Orr R, Myers T, MacGill T, Hensley LE, Muyembe-Tamfum JJ, Kaba D, Berry IM, Mbala-Kingebeni P, Lehrer AT, Rimoin AW. Comparison of EBOV GP IgG antibody reactivity: Results from two immunoassays in the Democratic Republic of the Congo. J Virol Methods. 2025 07; 336:115154. PMID: 40194662.
      Citations:    Fields:    Translation:HumansCells
    4. To A, Kamara VM, Tekah DM, Jalloh MA, Kamara SB, Wong TAS, Ball AH, Mayerlen LI, Ishikawa KM, Ahn HJ, Shobayo B, Teahton J, Haun BK, Wang WK, Berestecky JM, Nerurkar VR, Humphrey PS, Lehrer AT. Baseline Seroprevalence of Arboviruses in Liberia Using a Multiplex IgG Immunoassay. Trop Med Infect Dis. 2025 Apr 03; 10(4). PMID: 40278765.
      Citations:    
    5. Odo T, Haun BK, Williams CA, Ball A, To A, Wong TAS, Ching L, Nakano E, Van Ry A, Pessaint L, Andersen H, Donini O, Nerurkar VR, Lehrer AT. Use of a Multiplex Immunoassay Platform to Investigate Multifaceted Antibody Responses in SARS-CoV-2 Vaccinees with and Without Prior Infection. COVID. 2025 Apr; 5(4). PMID: 40406038.
      Citations:    
    6. Bailey R, Kahoekapu K, To A, Mayerlen LI, Kae H, Manninen G, Haun B, Berestecky J, Shikuma C, Lehrer AT, MacPherson I. Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors. bioRxiv. 2025 Mar 12. PMID: 40161655.
      Citations:    
    7. Ball A, Wong TAS, Lehrer AT. Detection of Serum Antibodies Targeting the Marburg Virus Glycoprotein Using a Multiplex Immunoassay Platform. Methods Mol Biol. 2025; 2877:345-354. PMID: 39585632.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Smith OA, Fujimoto B, Wong TAS, To A, Odo T, Ball A, Haun BK, Muramatsu H, Tam YK, Pardi N, Lehrer AT. Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes. COVID. 2025 Jan; 5(1). PMID: 40406709.
      Citations:    
    9. McLaury AR, Haun BK, To A, Mayerlen L, Medina LO, Lai CY, Wong TAS, Nakano E, Strange D, Aquino D, Huang YS, Higgs S, Vanlandingham DL, Garcia A, Berestecky JM, Lehrer AT. Characterization of Two Highly Specific Monoclonal Antibodies Targeting the Glycan Loop of the Zika Virus Envelope Protein. Viral Immunol. 2024 04; 37(3):167-175. PMID: 38574259.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Haun BK, To A, Williams CA, Ball A, Fong K, Wong TAS, Shobayo B, Teahton J, Ching L, Kamara V, Tekah DM, Humphrey P, Berestecky J, Nerurkar VR, Lehrer AT. A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT). Immuno. 2024 Mar; 4(1):108-124. PMID: 39391865.
      Citations:    
    11. Mayerlen LI, Wong TAS, Lehrer AT. A Microsphere Immunoassay for the Quantitative Detection of Antigens in Cell Culture Supernatant. Methods Mol Biol. 2024; 2829:277-286. PMID: 38951344.
      Citations:    Fields:    Translation:AnimalsCells
    12. To A, Wong TAS, Ball AH, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Elyard HA, Borisevich V, Agans KN, Deer DJ, Woolsey C, Cross RW, Geisbert TW, Donini O, Lehrer AT. Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection. Vaccine. 2024 01 25; 42(3):598-607. PMID: 38158300.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Williams CA, Wong TAS, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Andersen H, Geisbert TW, Lehrer AT. High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection. Immuno. 2023 Dec; 3(4):358-374. PMID: 40242024.
      Citations:    
    14. Williams CA, Wong TAS, Ball AH, Lieberman MM, Lehrer AT. Maternal Immunization Using a Protein Subunit Vaccine Mediates Passive Immunity against Zaire ebolavirus in a Murine Model. Viruses. 2022 12 14; 14(12). PMID: 36560788.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Chen D, Yun X, Lee D, DiCostanzo JR, Donini O, Shikuma CM, Thompson K, Lehrer AT, Shimoda L, Suk JS. Telmisartan Nanosuspension for Inhaled Therapy of COVID-19 Lung Disease and Other Respiratory Infections. Mol Pharm. 2023 01 02; 20(1):750-757. PMID: 36448927.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. Preston KB, Wong TAS, Lieberman MM, To A, Lai CY, Granados A, Thomasson H, Misamore J, Yalley-Ogunro J, Cabus M, Andersen H, Donini O, Lehrer AT, Randolph TW. Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates. J Pharm Sci. 2022 12; 111(12):3424-3434. PMID: 35609629.
      Citations: 1     Fields:    Translation:AnimalsCells
    17. To A, Lai CY, Wong TAS, Namekar M, Lieberman MM, Lehrer AT. Adjuvants Differentially Modulate the Immunogenicity of Lassa Virus Glycoprotein Subunits in Mice. Front Trop Dis. 2022; 3. PMID: 37034031.
      Citations:    
    18. To A, Wong TAS, Lieberman MM, Thompson K, Ball AH, Pessaint L, Greenhouse J, Daham N, Cook A, Narvaez B, Flinchbaugh Z, Van Ry A, Yalley-Ogunro J, Andersen Elyard H, Lai CY, Donini O, Lehrer AT. A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant. ACS Infect Dis. 2022 04 08; 8(4):825-840. PMID: 35263081.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Lai CY, To A, Ann S Wong T, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Furuyama W, Marzi A, Donini O, Lehrer AT. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice. Vaccine X. 2021 Nov 05; 100126. PMID: 34778744.
      Citations:    
    20. Lehrer AT, Chuang E, Namekar M, Williams CA, Wong TAS, Lieberman MM, Granados A, Misamore J, Yalley-Ogunro J, Andersen H, Geisbert JB, Agans KN, Cross RW, Geisbert TW. Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses. Front Immunol. 2021; 12:703986. PMID: 34484200.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Preston KB, Wong TAS, To A, Tashiro TE, Lieberman MM, Granados A, Feliciano K, Harrison J, Yalley-Ogunro J, Elyard HA, Donini O, Lehrer AT, Randolph TW. Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant. Vaccine. 2021 09 15; 39(39):5650-5657. PMID: 34400019.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Lai CY, To A, Wong TAS, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Donini O, Lehrer AT. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice. bioRxiv. 2021 Mar 03. PMID: 33688645.
      Citations:    
    23. Haun BK, Lai CY, Williams CA, Wong TAS, Lieberman MM, Pessaint L, Andersen H, Lehrer AT. CoVaccine HT? Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 Immunization. Front Immunol. 2020; 11:599587. PMID: 33193454.
      Citations: 23     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Preston KB, Monticello CR, Wong TAS, To A, Donini O, Lehrer AT, Randolph TW. Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays. J Pharm Sci. 2020 12; 109(12):3716-3727. PMID: 32931778.
      Citations: 6     Fields:    Translation:Cells
    25. Haun BK, Lai CY, Williams CA, Wong TA, Lieberman MM, Pessaint L, Andersen-Elyard H, Lehrer AT. CoVaccine HT? adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation. bioRxiv. 2020 Jul 26. PMID: 32743582.
      Citations:    
    26. Tyson J, Tsai WY, Tsai JJ, M?ssg?rd L, Stramer SL, Lehrer AT, Nerurkar VR, Wang WK. A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections. PLoS Negl Trop Dis. 2019 08; 13(8):e0007649. PMID: 31442225.
      Citations: 17     Fields:    Translation:Humans
    27. Haun BK, Kamara V, Dweh AS, Garalde-Machida K, Forkay SSE, Takaaze M, Namekar M, Wong TAS, Bell-Gam Woto AER, Humphreys P, Weeks OI, Fallah MP, Berestecky JM, Nerurkar VR, Lehrer AT. Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: A preliminary report. PLoS Negl Trop Dis. 2019 07; 13(7):e0007614. PMID: 31329600.
      Citations: 17     Fields:    Translation:AnimalsCells
    28. Lehrer AT, Wong TS, Lieberman MM, Johns L, Medina L, Feldmann F, Feldmann H, Marzi A. Recombinant subunit vaccines protect guinea pigs from lethal Ebola virus challenge. Vaccine. 2019 11 08; 37(47):6942-6950. PMID: 31324500.
      Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Chisholm CF, Kang TJ, Dong M, Lewis K, Namekar M, Lehrer AT, Randolph TW. Thermostable Ebola virus vaccine formulations lyophilized in the presence of aluminum hydroxide. Eur J Pharm Biopharm. 2019 Mar; 136:213-220. PMID: 30703544.
      Citations: 12     Fields:    Translation:AnimalsCells
    30. Medina LO, To A, Lieberman MM, Wong TAS, Namekar M, Nakano E, Andersen H, Yalley-Ogunro J, Greenhouse J, Higgs S, Huang YS, Vanlandingham DL, Horton JS, Clements DE, Lehrer AT. A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates. Front Immunol. 2018; 9:2464. PMID: 30467501.
      Citations: 26     Fields:    Translation:AnimalsCells
    31. To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere. 2018 Jan-Feb; 3(1). PMID: 29359186.
      Citations: 38     Fields:    
    32. Lai CY, Strange DP, Wong TAS, Lehrer AT, Verma S. Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4. Front Microbiol. 2017; 8:1571. PMID: 28861075.
      Citations:    
    33. Lehrer AT, Wong TS, Lieberman MM, Humphreys T, Clements DE, Bakken RR, Hart MK, Pratt WD, Dye JM. Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice. Vaccine. 2018 05 24; 36(22):3090-3100. PMID: 28216187.
      Citations: 30     Fields:    Translation:AnimalsCells
    34. Cregar-Hernandez L, Jiao GS, Johnson AT, Lehrer AT, Wong TA, Margosiak SA. Small molecule pan-dengue and West Nile virus NS3 protease inhibitors. Antivir Chem Chemother. 2011 May 12; 21(5):209-17. PMID: 21566267.
      Citations: 21     Fields:    Translation:AnimalsCells
    35. Lehrer AT, Holbrook MR. Tick-borne Encephalitis Vaccines. J Bioterror Biodef. 2011; 2011(Suppl 1):3. PMID: 23997980.
      Citations:    
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