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Axel Lehrer, PhD

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921614
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    Collapse Research 
    Collapse research activities and funding
    R43AI055225     (LEHRER, AXEL T)Jul 1, 2004 - Mar 31, 2007
    NIH
    Recombinant Subunit Vaccine for Tick-Borne Encephalitis
    Role: Principal Investigator
    R43AI066616     (LEHRER, AXEL T)Jun 15, 2007 - Nov 30, 2009
    NIH
    Development of a Recombinant Subunit Ebola Vaccine
    Role: Principal Investigator
    R01AI119185     (LEHRER, AXEL T)Aug 28, 2015 - Jul 31, 2021
    NIH
    Defining a Protective Ebola Vaccine in Non-Human Primates
    Role: Principal Investigator
    R01AI132323     (LEHRER, AXEL T)Jun 20, 2017 - May 31, 2022
    NIH
    Preclinical Development of a Thermostable Trivalent Filovirus Vaccine
    Role: Principal Investigator
    U01GH002256     (LEHRER, AXEL T)Sep 30, 2019 - Sep 29, 2024
    NIH
    GH19-003, Epidemiology and Immunity to Ebola Virus and Other Emerging Viral Infections in Liberia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McLaury AR, Haun BK, To A, Mayerlen L, Medina LO, Lai CY, Wong TAS, Nakano E, Strange D, Aquino D, Huang YS, Higgs S, Vanlandingham DL, Garcia A, Berestecky JM, Lehrer AT. Characterization of Two Highly Specific Monoclonal Antibodies Targeting the Glycan Loop of the Zika Virus Envelope Protein. Viral Immunol. 2024 04; 37(3):167-175. PMID: 38574259.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Mayerlen LI, Wong TAS, Lehrer AT. A Microsphere Immunoassay for the Quantitative Detection of Antigens in Cell Culture Supernatant. Methods Mol Biol. 2024; 2829:277-286. PMID: 38951344.
      Citations:    Fields:    Translation:AnimalsCells
    3. To A, Wong TAS, Ball AH, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Elyard HA, Borisevich V, Agans KN, Deer DJ, Woolsey C, Cross RW, Geisbert TW, Donini O, Lehrer AT. Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection. Vaccine. 2024 Jan 25; 42(3):598-607. PMID: 38158300.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Williams CA, Wong TAS, Ball AH, Lieberman MM, Lehrer AT. Maternal Immunization Using a Protein Subunit Vaccine Mediates Passive Immunity against Zaire ebolavirus in a Murine Model. Viruses. 2022 12 14; 14(12). PMID: 36560788.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    5. Chen D, Yun X, Lee D, DiCostanzo JR, Donini O, Shikuma CM, Thompson K, Lehrer AT, Shimoda L, Suk JS. Telmisartan Nanosuspension for Inhaled Therapy of COVID-19 Lung Disease and Other Respiratory Infections. Mol Pharm. 2023 01 02; 20(1):750-757. PMID: 36448927.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Preston KB, Wong TAS, Lieberman MM, To A, Lai CY, Granados A, Thomasson H, Misamore J, Yalley-Ogunro J, Cabus M, Andersen H, Donini O, Lehrer AT, Randolph TW. Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates. J Pharm Sci. 2022 12; 111(12):3424-3434. PMID: 35609629.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. To A, Lai CY, Wong TAS, Namekar M, Lieberman MM, Lehrer AT. Adjuvants Differentially Modulate the Immunogenicity of Lassa Virus Glycoprotein Subunits in Mice. Front Trop Dis. 2022; 3. PMID: 37034031.
      Citations:    
    8. To A, Wong TAS, Lieberman MM, Thompson K, Ball AH, Pessaint L, Greenhouse J, Daham N, Cook A, Narvaez B, Flinchbaugh Z, Van Ry A, Yalley-Ogunro J, Andersen Elyard H, Lai CY, Donini O, Lehrer AT. A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant. ACS Infect Dis. 2022 04 08; 8(4):825-840. PMID: 35263081.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Lai CY, To A, Ann S Wong T, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Furuyama W, Marzi A, Donini O, Lehrer AT. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice. Vaccine X. 2021 Nov 05; 100126. PMID: 34778744.
      Citations:    
    10. Lehrer AT, Chuang E, Namekar M, Williams CA, Wong TAS, Lieberman MM, Granados A, Misamore J, Yalley-Ogunro J, Andersen H, Geisbert JB, Agans KN, Cross RW, Geisbert TW. Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses. Front Immunol. 2021; 12:703986. PMID: 34484200.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    11. Preston KB, Wong TAS, To A, Tashiro TE, Lieberman MM, Granados A, Feliciano K, Harrison J, Yalley-Ogunro J, Elyard HA, Donini O, Lehrer AT, Randolph TW. Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant. Vaccine. 2021 09 15; 39(39):5650-5657. PMID: 34400019.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Lai CY, To A, Wong TAS, Lieberman MM, Clements DE, Senda JT, Ball AH, Pessaint L, Andersen H, Donini O, Lehrer AT. Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice. bioRxiv. 2021 Mar 03. PMID: 33688645.
      Citations:    
    13. Haun BK, Lai CY, Williams CA, Wong TAS, Lieberman MM, Pessaint L, Andersen H, Lehrer AT. CoVaccine HT? Adjuvant Potentiates Robust Immune Responses to Recombinant SARS-CoV-2 Spike S1 Immunization. Front Immunol. 2020; 11:599587. PMID: 33193454.
      Citations: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    14. Preston KB, Monticello CR, Wong TAS, To A, Donini O, Lehrer AT, Randolph TW. Preservation of Quaternary Structure in Thermostable, Lyophilized Filovirus Glycoprotein Vaccines: A Search for Stability-Indicating Assays. J Pharm Sci. 2020 12; 109(12):3716-3727. PMID: 32931778.
      Citations: 3     Fields:    Translation:Cells
    15. Haun BK, Lai CY, Williams CA, Wong TA, Lieberman MM, Pessaint L, Andersen-Elyard H, Lehrer AT. CoVaccine HT? adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation. bioRxiv. 2020 Jul 26. PMID: 32743582.
      Citations:    
    16. Tyson J, Tsai WY, Tsai JJ, M?ssg?rd L, Stramer SL, Lehrer AT, Nerurkar VR, Wang WK. A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections. PLoS Negl Trop Dis. 2019 08; 13(8):e0007649. PMID: 31442225.
      Citations: 14     Fields:    Translation:Humans
    17. Haun BK, Kamara V, Dweh AS, Garalde-Machida K, Forkay SSE, Takaaze M, Namekar M, Wong TAS, Bell-Gam Woto AER, Humphreys P, Weeks OI, Fallah MP, Berestecky JM, Nerurkar VR, Lehrer AT. Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: A preliminary report. PLoS Negl Trop Dis. 2019 07; 13(7):e0007614. PMID: 31329600.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Lehrer AT, Wong TS, Lieberman MM, Johns L, Medina L, Feldmann F, Feldmann H, Marzi A. Recombinant subunit vaccines protect guinea pigs from lethal Ebola virus challenge. Vaccine. 2019 11 08; 37(47):6942-6950. PMID: 31324500.
      Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    19. Chisholm CF, Kang TJ, Dong M, Lewis K, Namekar M, Lehrer AT, Randolph TW. Thermostable Ebola virus vaccine formulations lyophilized in the presence of aluminum hydroxide. Eur J Pharm Biopharm. 2019 Mar; 136:213-220. PMID: 30703544.
      Citations: 9     Fields:    Translation:AnimalsCells
    20. Medina LO, To A, Lieberman MM, Wong TAS, Namekar M, Nakano E, Andersen H, Yalley-Ogunro J, Greenhouse J, Higgs S, Huang YS, Vanlandingham DL, Horton JS, Clements DE, Lehrer AT. A Recombinant Subunit Based Zika Virus Vaccine Is Efficacious in Non-human Primates. Front Immunol. 2018; 9:2464. PMID: 30467501.
      Citations: 21     Fields:    Translation:AnimalsCells
    21. To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT. Recombinant Zika Virus Subunits Are Immunogenic and Efficacious in Mice. mSphere. 2018 Jan-Feb; 3(1). PMID: 29359186.
      Citations: 30     Fields:    
    22. Lai CY, Strange DP, Wong TAS, Lehrer AT, Verma S. Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4. Front Microbiol. 2017; 8:1571. PMID: 28861075.
      Citations:    
    23. Lehrer AT, Wong TS, Lieberman MM, Humphreys T, Clements DE, Bakken RR, Hart MK, Pratt WD, Dye JM. Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice. Vaccine. 2018 05 24; 36(22):3090-3100. PMID: 28216187.
      Citations: 24     Fields:    Translation:AnimalsCells
    24. Jiao GS, Kim S, Moayeri M, Crown D, Thai A, Cregar-Hernandez L, McKasson L, Sankaran B, Lehrer A, Wong T, Johns L, Margosiak SA, Leppla SH, Johnson AT. Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15; 22(6):2242-6. PMID: 22342144.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Pusic KM, Hashimoto CN, Lehrer A, Aniya C, Clements DE, Hui GS. T cell epitope regions of the P. falciparum MSP1-33 critically influence immune responses and in vitro efficacy of MSP1-42 vaccines. PLoS One. 2011; 6(9):e24782. PMID: 21931852.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    26. Cregar-Hernandez L, Jiao GS, Johnson AT, Lehrer AT, Wong TA, Margosiak SA. Small molecule pan-dengue and West Nile virus NS3 protease inhibitors. Antivir Chem Chemother. 2011 May 12; 21(5):209-17. PMID: 21566267.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Lehrer AT, Holbrook MR. Tick-borne Encephalitis Vaccines. J Bioterror Biodef. 2011; 2011(Suppl 1):3. PMID: 23997980.
      Citations:    
    28. Zhu YJ, McCafferty H, Osterman G, Lim S, Agbayani R, Lehrer A, Schenck S, Komor E. Genetic transformation with untranslatable coat protein gene of sugarcane yellow leaf virus reduces virus titers in sugarcane. Transgenic Res. 2011 Jun; 20(3):503-12. PMID: 20661641.
      Citations: 8     Fields:    Translation:AnimalsCells
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