Alkylating Agents

"Alkylating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

Descriptor ID	D000477
MeSH Number(s)	D27.505.519.124 D27.888.569.035
Concept/Terms	Alkylating Agents Alkylating Agents Agents, Alkylating Alkylators

Below are MeSH descriptors whose meaning is more general than "Alkylating Agents".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Alkylating Agents [D27.505.519.124]
Toxic Actions [D27.888]
Noxae [D27.888.569]
Alkylating Agents [D27.888.569.035]

Below are MeSH descriptors whose meaning is related to "Alkylating Agents".

Below are MeSH descriptors whose meaning is more specific than "Alkylating Agents".

Alkylating Agents
Antineoplastic Agents, Alkylating

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alkylating Agents" by people in this website by year, and whether "Alkylating Agents" was a major or minor topic of these publications.

Bar chart showing 13 publications over 9 distinct years, with a maximum of 2 publications in 2000 and 2013 and 2014 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2004	1	0	1
2007	0	1	1
2009	0	1	1
2013	1	1	2
2014	2	0	2
2015	1	1	2
2016	0	1	1
2018	1	0	1

Below are the most recent publications written about "Alkylating Agents" by people in Profiles.

Nguyen AH, Fatehi N, Romero P, Miraftabi A, Kim E, Morales E, Giaconi J, Coleman AL, Law SK, Caprioli J, Nouri-Mahdavi K. Observational Outcomes of Initial Trabeculectomy With Mitomycin C in Patients of African Descent vs Patients of European Descent: Five-Year Results. JAMA Ophthalmol. 2018 10 01; 136(10):1106-1113.

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Hu CW, Cooke MS, Chang YJ, Chao MR. Direct-acting DNA ethylating agents associated with tobacco use primarily originate from the tobacco itself, not combustion. J Hazard Mater. 2018 09 15; 358:397-404.

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Song BJ, Ramanathan M, Morales E, Law SK, Giaconi JA, Coleman AL, Caprioli J. Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma. J Glaucoma. 2016 09; 25(9):763-9.

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Habibollahi A, Hashemi H, Seyedian MA, Mehravaran S, Asgari S, Habibollahi S, Habibollahi S, Khabazkhoob M. One Year Outcomes of Photorefractive Keratectomy with the Application of Mitomycin-C in the Treatment of Mild to Moderate Hyperopia. Middle East Afr J Ophthalmol. 2015 Oct-Dec; 22(4):484-8.

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Kim EA, Law SK, Coleman AL, Nouri-Mahdavi K, Giaconi JA, Yu F, Lee JW, Caprioli J. Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and?Influence of Bleb Revision. Am J Ophthalmol. 2015 Jun; 159(6):1082-91.

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Nassiri N, Sheibani K, Safi S, Haghnegahdar M, Nassiri S, Panahi N, Mehravaran S, Nassiri N. Alcohol-assisted debridement in PRK with intraoperative mitomycin C. Optom Vis Sci. 2014 Sep; 91(9):1084-8.

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Kwong A, Law SK, Kule RR, Nouri-Mahdavi K, Coleman AL, Caprioli J, Giaconi JA. Long-term outcomes of resident- versus attending-performed primary trabeculectomy with mitomycin C in a United States residency program. Am J Ophthalmol. 2014 Jun; 157(6):1190-201.

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Khazal KF, Samuel T, Hill DL, Grubbs CJ. Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas. Anticancer Res. 2013 Apr; 33(4):1519-23.

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Farahi A, Hashemi H, Mehravaran S. The effects of mitomycin C on tear function after photorefractive keratectomy: a contralateral comparative study. J Refract Surg. 2013 Apr; 29(4):260-4.

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Diwan BA, Timofeeva O, Rice JM, Yang Y, Sharma N, Fortini ME, Wang H, Perantoni AO. Inheritance of susceptibility to induction of nephroblastomas in the Noble rat. Differentiation. 2009 Apr; 77(4):424-32.

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