Cystatins

"Cystatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A homologous group of endogenous CYSTEINE PROTEINASE INHIBITORS. The cystatins inhibit most CYSTEINE ENDOPEPTIDASES such as PAPAIN, and other peptidases which have a sulfhydryl group at the active site.

Descriptor ID	D015891
MeSH Number(s)	D12.776.215
Concept/Terms	Cystatins Cystatins Cystatin Superfamily Type 3 Cystatins Type 3 Cystatins Cystatins, Type 3 Type III Cystatins Cystatins, Type III Type 2 Cystatins Type 2 Cystatins Cystatins, Type 2 Type II Cystatins Cystatins, Type II Cystatin-Related Proteins Cystatin-Related Proteins Cystatin Related Proteins Type 1 Cystatins Type 1 Cystatins Cystatins, Type 1 Type I Cystatins Cystatins, Type I Stefins

Below are MeSH descriptors whose meaning is more general than "Cystatins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cystatins [D12.776.215]

Below are MeSH descriptors whose meaning is related to "Cystatins".

Below are MeSH descriptors whose meaning is more specific than "Cystatins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cystatins" by people in this website by year, and whether "Cystatins" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 2 publications in 2006 and 2007 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	2	0	2
2007	1	1	2
2010	1	0	1
2013	1	0	1
2018	1	1	2
2019	1	0	1

Below are the most recent publications written about "Cystatins" by people in Profiles.

Holloway AJ, Yu J, Arulanandam BP, Milligan GN, Eaves-Pyles TD. Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 2019 05; 63(5).

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Holloway AJ, Yu J, Arulanandam BP, Hoskinson SM, Eaves-Pyles T. Cystatins 9 and C as a Novel Immunotherapy Treatment That Protects against Multidrug-Resistant New Delhi Metallo-Beta-Lactamase-1-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2018 03; 62(3).

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Verdes A, Simpson D, Holford M. Are Fireworms Venomous? Evidence for the Convergent Evolution of Toxin Homologs in Three Species of Fireworms (Annelida, Amphinomidae). Genome Biol Evol. 2018 01 01; 10(1):249-268.

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Eaves-Pyles T, Patel J, Arigi E, Cong Y, Cao A, Garg N, Dhiman M, Pyles RB, Arulanandam B, Miller AL, Popov VL, Soong L, Carlsen ED, Coletta C, Szabo C, Almeida IC. Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis. Mol Med. 2013 Aug 28; 19:263-75.

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Ochieng J, Chaudhuri G. Cystatin superfamily. J Health Care Poor Underserved. 2010 Feb; 21(1 Suppl):51-70.

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Lee DC, Mason CW, Goodman CB, Holder MS, Kirksey OW, Womble TA, Severs WB, Palm DE. Hydrogen peroxide induces lysosomal protease alterations in PC12 cells. Neurochem Res. 2007 Sep; 32(9):1499-510.

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Cotter RJ, Griffith W, Jelinek C. Tandem time-of-flight (TOF/TOF) mass spectrometry and the curved-field reflectron. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug; 855(1):2-13.

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Lee DC, Womble TA, Mason CW, Jackson IM, Lamango NS, Severs WB, Palm DE. 6-Hydroxydopamine induces cystatin C-mediated cysteine protease suppression and cathepsin D activation. Neurochem Int. 2007 Mar; 50(4):607-18.

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Lee DC, Close FT, Goodman CB, Jackson IM, Wight-Mason C, Wells LM, Womble TA, Palm DE. Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure. Neurotoxicology. 2006 Mar; 27(2):260-76.

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Ray S, Lukyanov P, Ochieng J. Members of the cystatin superfamily interact with MMP-9 and protect it from autolytic degradation without affecting its gelatinolytic activities. Biochim Biophys Acta. 2003 Dec 01; 1652(2):91-102.

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