rho-Associated Kinases

"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Descriptor ID	D054460
MeSH Number(s)	D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
Concept/Terms	rho-Associated Kinases rho-Associated Kinases rho Associated Kinases rho-Associated Kinase rho Associated Kinase ROCK Protein Kinases Protein Kinases, ROCK rho-Associated Coiled-Coil Kinase Coiled-Coil Kinase, rho-Associated rho Associated Coiled Coil Kinase rho-Kinase rho Kinase ROK Kinase rho-Associated Kinase 1 rho-Associated Kinase 1 rho Associated Kinase 1 ROCK-I Protein Kinase ROCK I Protein Kinase p160ROCK rho-Associated Kinase beta rho Associated Kinase beta rho-Associated Protein Kinase beta rho Associated Protein Kinase beta rho-Associated Coiled-Coil Containing Protein Kinase 1 rho Associated Coiled Coil Containing Protein Kinase 1 rho-Associated Kinase 2 rho-Associated Kinase 2 rho Associated Kinase 2 rho-Associated Kinase alpha rho Associated Kinase alpha rho-Associated Coiled-Coil Containing Protein Kinase 2 rho Associated Coiled Coil Containing Protein Kinase 2 ROCK-II Protein Kinase ROCK II Protein Kinase p160 rhoA-Binding Kinase ROKalpha p160 rhoA Binding Kinase ROKalpha rho-Associated Protein Kinase alpha rho Associated Protein Kinase alpha

Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
rho-Associated Kinases [D08.811.913.696.620.682.700.814]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
rho-Associated Kinases [D12.644.360.590]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
rho-Associated Kinases [D12.776.476.595]

Below are MeSH descriptors whose meaning is related to "rho-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 26 publications over 17 distinct years, with a maximum of 3 publications in 2004 and 2006 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2003	0	1	1
2004	0	3	3
2006	0	3	3
2007	0	1	1
2008	0	1	1
2009	1	0	1
2011	2	0	2
2012	0	1	1
2013	1	2	3
2014	2	0	2
2016	0	1	1
2017	0	2	2
2018	1	0	1
2021	0	1	1
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.

Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023 02 01; 324(2):L190-L198.

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Alarcon VB, Marikawa Y. Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling. Reproduction. 2022 10 01; 164(4):R75-R86.

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Mondal T, Shivange GN, Tihagam RG, Lyerly E, Battista M, Talwar D, Mosavian R, Urbanek K, Rashid NS, Harrell JC, Bos PD, Stelow EB, Stack MS, Bhatnagar S, Tushir-Singh J. Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Mol Med. 2021 03 05; 13(3):e12716.

View in: PubMed
Alarcon VB, Marikawa Y. ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation. Adv Anat Embryol Cell Biol. 2018; 229:47-68.

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Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL. mTORC1 loss impairs epidermal adhesion via TGF-?/Rho kinase activation. J Clin Invest. 2017 Nov 01; 127(11):4001-4017.

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Fan R, Enkhjargal B, Camara R, Yan F, Gong L, Tang J, Chen Y, Zhang JH. Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat. Exp Neurol. 2017 10; 296:41-48.

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Peng KY, Lee YW, Hsu PJ, Wang HH, Wang Y, Liou JY, Hsu SH, Wu KK, Yen BL. Human pluripotent stem cell (PSC)-derived mesenchymal stem cells (MSCs) show potent neurogenic capacity which is enhanced with cytoskeletal rearrangement. Oncotarget. 2016 Jul 12; 7(28):43949-43959.

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Kono K, Tamashiro DA, Alarcon VB. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev Biol. 2014 Oct 01; 394(1):142-55.

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Shin JY, Kim YI, Cho SJ, Lee MK, Kook MC, Lee JH, Lee SS, Ashktorab H, Smoot DT, Ryu KW, Kim YW, Choi IJ. MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer. PLoS One. 2014; 9(1):e85205.

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Laeno AM, Tamashiro DA, Alarcon VB. Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol Reprod. 2013 Nov; 89(5):122.

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