rho-Associated Kinases

"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

Descriptor ID	D054460
MeSH Number(s)	D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
Concept/Terms	rho-Associated Kinases rho-Associated Kinases rho Associated Kinases rho-Associated Kinase rho Associated Kinase ROCK Protein Kinases Protein Kinases, ROCK rho-Associated Coiled-Coil Kinase Coiled-Coil Kinase, rho-Associated rho Associated Coiled Coil Kinase rho-Kinase rho Kinase ROK Kinase rho-Associated Kinase 1 rho-Associated Kinase 1 rho Associated Kinase 1 ROCK-I Protein Kinase ROCK I Protein Kinase p160ROCK rho-Associated Kinase beta rho Associated Kinase beta rho-Associated Protein Kinase beta rho Associated Protein Kinase beta rho-Associated Coiled-Coil Containing Protein Kinase 1 rho Associated Coiled Coil Containing Protein Kinase 1 rho-Associated Kinase 2 rho-Associated Kinase 2 rho Associated Kinase 2 rho-Associated Kinase alpha rho Associated Kinase alpha rho-Associated Coiled-Coil Containing Protein Kinase 2 rho Associated Coiled Coil Containing Protein Kinase 2 ROCK-II Protein Kinase ROCK II Protein Kinase p160 rhoA-Binding Kinase ROKalpha p160 rhoA Binding Kinase ROKalpha rho-Associated Protein Kinase alpha rho Associated Protein Kinase alpha

Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
rho-Associated Kinases [D08.811.913.696.620.682.700.814]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
rho-Associated Kinases [D12.644.360.590]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
rho-Associated Kinases [D12.776.476.595]

Below are MeSH descriptors whose meaning is related to "rho-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 30 publications over 18 distinct years, with a maximum of 3 publications in 2004 and 2006 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2003	0	1	1
2004	0	3	3
2006	0	3	3
2007	0	1	1
2008	1	1	2
2009	1	0	1
2011	2	0	2
2012	0	1	1
2013	1	1	2
2014	2	0	2
2017	0	2	2
2018	2	1	3
2020	1	0	1
2021	0	1	1
2022	0	1	1
2023	0	1	1
2025	1	1	2

Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.

Pal A, Bawali P, Brahma A, Rana SR, Mohapatra R, Chakraborty D, Poirah I, Samal S, Banerjee S, Smoot DT, Ashktorab H, Bhattacharyya A. RHOA-dependent regulation of mitochondrial remodeling and cell motility in hypoxia-exposed gastric epithelial cells. J Cell Sci. 2025 Jul 15; 138(14).

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Tran NNQ, Choi H, Sactivel B, Oh YJ, Maeng HJ, Kim MK, Lee J, Kim YB, Lee DH, Oh BC, Jun HS, Chun KH. The dual targeting effects of KD025 on casein kinase 2 and ROCK2 in a mouse model of diet-induced obesity. Biochem Pharmacol. 2025 Jul; 237:116933.

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Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023 02 01; 324(2):L190-L198.

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Alarcon VB, Marikawa Y. Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling. Reproduction. 2022 10 01; 164(4):R75-R86.

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Mondal T, Shivange GN, Tihagam RG, Lyerly E, Battista M, Talwar D, Mosavian R, Urbanek K, Rashid NS, Harrell JC, Bos PD, Stelow EB, Stack MS, Bhatnagar S, Tushir-Singh J. Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Mol Med. 2021 03 05; 13(3):e12716.

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Oh YJ, Kim H, Kim AJ, Ro H, Chang JH, Lee HH, Chung W, Jun HS, Jung JY. Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease. Int J Mol Sci. 2020 May 17; 21(10).

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Komatsu N, Kajiya M, Motoike S, Takewaki M, Horikoshi S, Iwata T, Ouhara K, Takeda K, Matsuda S, Fujita T, Kurihara H. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Stem Cell Res Ther. 2018 12 07; 9(1):342.

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Diep DTV, Hong K, Khun T, Zheng M, Ul-Haq A, Jun HS, Kim YB, Chun KH. Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells. Sci Rep. 2018 02 06; 8(1):2477.

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Alarcon VB, Marikawa Y. ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation. Adv Anat Embryol Cell Biol. 2018; 229:47-68.

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Asrani K, Sood A, Torres A, Georgess D, Phatak P, Kaur H, Dubin A, Talbot CC, Elhelu L, Ewald AJ, Xiao B, Worley P, Lotan TL. mTORC1 loss impairs epidermal adhesion via TGF-?/Rho kinase activation. J Clin Invest. 2017 Nov 01; 127(11):4001-4017.

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