AMP-Activated Protein Kinases

"AMP-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.

Descriptor ID	D055372
MeSH Number(s)	D08.811.913.696.620.682.700.085 D12.644.360.062 D12.776.476.062
Concept/Terms	AMP-Activated Protein Kinases AMP-Activated Protein Kinases AMP Activated Protein Kinases AMP-Activated Kinase AMP Activated Kinase AMP-Activated Protein Kinase AMP Activated Protein Kinase 5'-AMP-Activated Protein Kinase 5' AMP Activated Protein Kinase AMP-Activated Protein Kinase beta Subunits AMP-Activated Protein Kinase beta Subunits AMP Activated Protein Kinase beta Subunits AMP-Activated Protein Kinase beta Subunit AMP Activated Protein Kinase beta Subunit AMP-Activated Protein Kinase gamma Subunits AMP-Activated Protein Kinase gamma Subunits AMP Activated Protein Kinase gamma Subunits AMP-Activated Protein Kinase gamma Subunit AMP Activated Protein Kinase gamma Subunit AMP-Activated Protein Kinase alpha Subunits AMP-Activated Protein Kinase alpha Subunits AMP Activated Protein Kinase alpha Subunits PRKAA AMP-Activated Protein Kinase alpha Subunit AMP Activated Protein Kinase alpha Subunit

Below are MeSH descriptors whose meaning is more general than "AMP-Activated Protein Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
AMP-Activated Protein Kinases [D12.644.360.062]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
AMP-Activated Protein Kinases [D12.776.476.062]

Below are MeSH descriptors whose meaning is related to "AMP-Activated Protein Kinases".

Below are MeSH descriptors whose meaning is more specific than "AMP-Activated Protein Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "AMP-Activated Protein Kinases" by people in this website by year, and whether "AMP-Activated Protein Kinases" was a major or minor topic of these publications.

Bar chart showing 25 publications over 13 distinct years, with a maximum of 4 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	2	2
2009	0	1	1
2012	0	3	3
2013	0	1	1
2014	1	0	1
2015	2	0	2
2016	0	3	3
2017	1	0	1
2018	2	1	3
2019	1	0	1
2020	1	3	4
2021	2	0	2
2022	0	1	1

Below are the most recent publications written about "AMP-Activated Protein Kinases" by people in Profiles.

Abdou HM, Hamaad FA, Ali EY, Ghoneum MH. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomed Pharmacother. 2022 May; 149:112838.

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Simino LAP, Panzarin C, Fontana MF, de Fante T, Geraldo MV, Ign?cio-Souza LM, Milanski M, Torsoni MA, Ross MG, Desai M, Torsoni AS. MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies. Sci Rep. 2021 04 26; 11(1):8980.

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Lu J, Chen PP, Zhang JX, Li XQ, Wang GH, Yuan BY, Huang SJ, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL. GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKa activity. Theranostics. 2021; 11(10):4728-4742.

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Hasan KM, Munoz A, Tumoyan H, Parveen M, Espinoza-Derout J, Shao XM, Mahata SK, Friedman TC, Sinha-Hikim AP. Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts. Exp Mol Pathol. 2021 02; 118:104573.

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Desai M, Ferrini MG, Han G, Narwani K, Ross MG. Maternal High Fat Diet Programs Male Mice Offspring Hyperphagia and Obesity: Mechanism of Increased Appetite Neurons via Altered Neurogenic Factors and Nutrient Sensor AMPK. Nutrients. 2020 Oct 29; 12(11).

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Donoso-Bustamante V, Borrego EA, Schiaffino-Bustamante Y, Guti?rrez DA, Millas-Vargas JP, Fuentes-Retamal S, Correa P, Carrillo I, Aguilera RJ, Miranda D, Ch?vez-B?ez I, Pulgar R, Urra FA, Varela-Ram?rez A, Araya-Maturana R. An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells. Bioorg Chem. 2020 07; 100:103935.

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Yu J, Wang WN, Matei N, Li X, Pang JW, Mo J, Chen SP, Tang JP, Yan M, Zhang JH. Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. Oxid Med Cell Longev. 2020; 2020:4717258.

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Cao W, Li J, Hao Q, Vadgama JV, Wu Y. AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer. Breast Cancer Res. 2019 02 21; 21(1):29.

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Yu J, Li X, Matei N, McBride D, Tang J, Yan M, Zhang JH. Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats. Exp Neurol. 2018 09; 307:12-23.

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Chen S, Zhao L, Sherchan P, Ding Y, Yu J, Nowrangi D, Tang J, Xia Y, Zhang JH. Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice. J Neuroinflammation. 2018 Apr 11; 15(1):106.

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