MAP Kinase Kinase Kinases

"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).

Descriptor ID	D020930
MeSH Number(s)	D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
Concept/Terms	MAP Kinase Kinase Kinases MAP Kinase Kinase Kinases Mitogen-Activated Protein Kinase Kinase Kinases Mitogen Activated Protein Kinase Kinase Kinases Kinases, MAP Kinase Kinase MAP3 Kinases Kinases, MAP3 MAP Kinase Kinase Kinase MAPKKKs MAPK-ERK Kinase Kinases MAPK-ERK Kinase Kinases Kinase Kinases, MAPK-ERK Kinases, MAPK-ERK Kinase MAPK ERK Kinase Kinases MEK Kinases Kinases, MEK MEKKs

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
MAP Kinase Kinase Kinases [D12.644.360.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
MAP Kinase Kinase Kinases [D12.776.476.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase Kinases".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.

Bar chart showing 13 publications over 11 distinct years, with a maximum of 2 publications in 2011 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	0	1
2007	1	0	1
2008	0	1	1
2010	1	0	1
2011	0	2	2
2013	0	1	1
2014	0	1	1
2015	1	1	2
2016	1	0	1
2017	0	1	1
2021	1	0	1

Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.

Kaushal JB, Shukla V, Sankhwar P, Jha RK, Dwivedi A. Targeted inhibition of TAK1 abrogates TGF?1 non-canonical signaling axis, NF?B/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy. Cytokine. 2021 12; 148:155700.

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Pervin S, Singh V, Tucker A, Collazo J, Singh R. Modulation of transforming growth factor-?/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders. Horm Mol Biol Clin Investig. 2017 Sep 09; 31(2).

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Yin C, Huang GF, Sun XC, Guo Z, Zhang JH. Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats. Neuropharmacology. 2016 09; 108:316-23.

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Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, Day A, Sadrud-Din S, Flores-Rozas H, Soliman KF, Darling-Reed S. Diallyl disulfide inhibits TNFa induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine. 2015 Sep; 75(1):117-26.

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West RJ, Lu Y, Marie B, Gao FB, Sweeney ST. Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia. J Cell Biol. 2015 Mar 30; 208(7):931-47.

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Yellen P, Foster DA. Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Lett. 2014 Oct 28; 353(2):258-63.

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Lee C, Oh JI, Park J, Choi JH, Bae EK, Lee HJ, Jung WJ, Lee DS, Ahn KS, Yoon SS. TNF a mediated IL-6 secretion is regulated by JAK/STAT pathway but not by MEK phosphorylation and AKT phosphorylation in U266 multiple myeloma cells. Biomed Res Int. 2013; 2013:580135.

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Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A. The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor ? (TGF-?) signaling and the development of regulatory T cells. J Biol Chem. 2011 Nov 25; 286(47):40520-30.

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Fung KY, Brierley GV, Henderson S, Hoffmann P, McColl SR, Lockett T, Head R, Cosgrove L. Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response. J Proteome Res. 2011 Apr 01; 10(4):1860-9.

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Liou GY, Zhang H, Miller EM, Seibold SA, Chen W, Gallo KA. Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling. Biochem J. 2010 Apr 14; 427(3):435-43.

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