Ribosomal Protein S6 Kinases

"Ribosomal Protein S6 Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

Descriptor ID	D019893
MeSH Number(s)	D08.811.913.696.620.682.700.862 D12.644.360.600 D12.776.476.600
Concept/Terms	Ribosomal Protein S6 Kinases Ribosomal Protein S6 Kinases S6-H4 Kinase S6 H4 Kinase Ribosomal Protein S6 Kinase S6 Kinase

Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Ribosomal Protein S6 Kinases [D12.644.360.600]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Ribosomal Protein S6 Kinases [D12.776.476.600]

Below are MeSH descriptors whose meaning is related to "Ribosomal Protein S6 Kinases".

Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases" by people in this website by year, and whether "Ribosomal Protein S6 Kinases" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	0	2	2
2003	0	1	1
2005	0	1	1
2008	0	1	1
2013	1	0	1
2014	0	1	1
2017	0	1	1

Below are the most recent publications written about "Ribosomal Protein S6 Kinases" by people in Profiles.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD. Glycogen synthase kinase-3? ablation limits pancreatitis-induced acinar-to-ductal metaplasia. J Pathol. 2017 09; 243(1):65-77.

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Chak A, Buttar NS, Foster NR, Seisler DK, Marcon NE, Schoen R, Cruz-Correa MR, Falk GW, Sharma P, Hur C, Katzka DA, Rodriguez LM, Richmond E, Sharma AN, Smyrk TC, Mandrekar SJ, Limburg PJ. Metformin does not reduce markers of cell proliferation in esophageal tissues of patients with Barrett's esophagus. Clin Gastroenterol Hepatol. 2015 Apr; 13(4):665-72.e1-4.

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Yellen P, Chatterjee A, Preda A, Foster DA. Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-?-dependent G1 cell cycle arrest. Cancer Lett. 2013 Jun 10; 333(2):239-43.

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Mohankumar V, Dhanushkodi NR, Raju R. Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells. Biochem Biophys Res Commun. 2011 Mar 11; 406(2):262-7.

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Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar; 29(6):1411-20.

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Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA. mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem. 2005 Oct 28; 280(43):35829-35.

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Chen Y, Zheng Y, Foster DA. Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene. 2003 Jun 19; 22(25):3937-42.

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Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002 Jun 21; 277(25):22896-901.

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Reynolds CM, Eguchi S, Frank GD, Motley ED. Signaling mechanisms of heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells. Hypertension. 2002 Feb; 39(2 Pt 2):525-9.

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Jiang H, Foltenyi K, Kashiwada M, Donahue L, Vuong B, Hehn B, Rothman P. Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation. J Immunol. 2001 Feb 15; 166(4):2627-34.

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