Mitogen-Activated Protein Kinase Kinases

"Mitogen-Activated Protein Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.

Descriptor ID	D020929
MeSH Number(s)	D08.811.913.696.620.682.700.565 D08.811.913.696.620.682.725.200 D12.644.360.440 D12.776.476.440
Concept/Terms	Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinase Kinases Mitogen Activated Protein Kinase Kinases MAPKK MAPKKs MAP Kinase Kinases Kinase Kinases, MAP Kinases, MAP Kinase MAPK Kinases Kinases, MAPK Map Kinase Kinase Kinase Kinase, Map Kinase, Map Kinase MAPK-ERK Kinases MAPK-ERK Kinases Kinases, MAPK-ERK MAPK ERK Kinases MEKs MAP-ERK Kinase Kinase, MAP-ERK MAP ERK Kinase

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinase Kinases".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase Kinases".

Mitogen-Activated Protein Kinase Kinases
MAP Kinase Kinase 1
MAP Kinase Kinase 2
MAP Kinase Kinase 3
MAP Kinase Kinase 4
MAP Kinase Kinase 5
MAP Kinase Kinase 6
MAP Kinase Kinase 7

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinase Kinases" was a major or minor topic of these publications.

Bar chart showing 29 publications over 17 distinct years, with a maximum of 4 publications in 1998 and 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	3	1	4
1999	1	0	1
2000	1	1	2
2001	0	1	1
2002	1	1	2
2003	3	1	4
2004	0	1	1
2006	0	1	1
2007	0	1	1
2009	0	1	1
2010	1	2	3
2011	0	2	2
2012	0	1	1
2018	1	0	1
2020	0	1	1
2021	1	1	2
2022	0	1	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinase Kinases" by people in Profiles.

Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H. Fibroblast GSK-3a Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart. Circ Res. 2022 09 16; 131(7):620-636.

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Vu T, Datta A, Banister C, Jin L, Yuan G, Samuel T, Bae S, Eltoum IE, Manne U, Zhang B, Welner RS, Mitra K, Buckhaults P, Datta PK. Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism. Gastroenterology. 2022 01; 162(1):193-208.

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Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS. Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell. 2021 10 11; 39(10):1375-1387.e6.

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Ahmad S, He Q, Williams KP, Scott JE. Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach. SLAS Discov. 2020 09; 25(8):923-938.

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House CD, Grajales V, Ozaki M, Jordan E, Wubneh H, Kimble DC, James JM, Kim MK, Annunziata CM. I??e cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts. BMC Cancer. 2018 May 25; 18(1):595.

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Martin EC, Bratton MR, Zhu Y, Rhodes LV, Tilghman SL, Collins-Burow BM, Burow ME. Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell line. PLoS One. 2012; 7(11):e49067.

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Zeng X, Yu SP, Taylor T, Ogle M, Wei L. Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis. Stem Cell Res. 2012 May; 8(3):357-67.

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Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 2011 Apr; 7(4):e1001361.

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Tiwary R, Yu W, Sanders BG, Kline K. a-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways. Br J Cancer. 2011 Jan 04; 104(1):101-9.

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Chen MC, Wang SW, Kan SF, Tsai SC, Wu YC, Wang PS. Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. Toxicol Sci. 2010 Dec; 118(2):667-74.

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