Interleukin-1 Receptor-Associated Kinases

"Interleukin-1 Receptor-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling from these kinases involves their interaction with SIGNAL TRANSDUCING ADAPTOR PROTEINS such as MYELOID DIFFERENTIATION FACTOR 88 and TNF RECEPTOR-ASSOCIATED FACTOR 6.

Descriptor ID	D053592
MeSH Number(s)	D08.811.913.696.620.682.700.526 D12.644.360.370 D12.776.476.384
Concept/Terms	Interleukin-1 Receptor-Associated Kinases Interleukin-1 Receptor-Associated Kinases Interleukin 1 Receptor Associated Kinases Kinases, Interleukin-1 Receptor-Associated Receptor-Associated Kinases, Interleukin-1 IRAK Kinases Kinases, IRAK IL-1 Receptor-Associated Kinase IL 1 Receptor Associated Kinase Kinase, IL-1 Receptor-Associated Receptor-Associated Kinase, IL-1 Interleukin-1 Receptor-Associated Kinase Interleukin 1 Receptor Associated Kinase Kinase, Interleukin-1 Receptor-Associated Receptor-Associated Kinase, Interleukin-1 Interleukin-1 Receptor-Associated Kinase 4 Interleukin-1 Receptor-Associated Kinase 4 Interleukin 1 Receptor Associated Kinase 4 IRAK-4 Kinase IRAK 4 Kinase Kinase, IRAK-4 Interleukin-1 Receptor-Associated Kinase 3 Interleukin-1 Receptor-Associated Kinase 3 Interleukin 1 Receptor Associated Kinase 3 IRAK-3 Kinase IRAK 3 Kinase Kinase, IRAK-3 Interleukin-1 Receptor-Associated Kinase 1 Interleukin-1 Receptor-Associated Kinase 1 Interleukin 1 Receptor Associated Kinase 1 IRAK-1 Kinase IRAK 1 Kinase Kinase, IRAK-1 Interleukin-1 Receptor-Associated Kinase 2 Interleukin-1 Receptor-Associated Kinase 2 Interleukin 1 Receptor Associated Kinase 2 IRAK-2 Kinase IRAK 2 Kinase Kinase, IRAK-2

Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor-Associated Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Interleukin-1 Receptor-Associated Kinases [D12.644.360.370]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]

Below are MeSH descriptors whose meaning is related to "Interleukin-1 Receptor-Associated Kinases".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor-Associated Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-1 Receptor-Associated Kinases" by people in this website by year, and whether "Interleukin-1 Receptor-Associated Kinases" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2003 and 2007 and 2009 and 2010 and 2012 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2007	1	0	1
2009	1	0	1
2010	0	1	1
2012	1	0	1
2013	0	1	1
2015	0	1	1

Below are the most recent publications written about "Interleukin-1 Receptor-Associated Kinases" by people in Profiles.

Ma C, Spies NP, Gong T, Jones CX, Chu WM. Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners. PLoS One. 2015; 10(3):e0121371.

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Rogers EN, Jones DZ, Kidd NC, Yeyeodu S, Brock G, Ragin C, Jackson M, McFarlane-Anderson N, Tulloch-Reid M, Sean Kimbro K, Kidd LR. Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent. Genes Immun. 2013 Sep; 14(6):347-55.

View in: PubMed
Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarc?n GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vil? LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons Estel BA, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarc?n-Riquelme ME, Jacob CO, Moser Sivils K, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013 Mar; 72(3):437-44.

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Conway DH, Dara J, Bagashev A, Sullivan KE. Myeloid differentiation primary response gene 88 (MyD88) deficiency in a large kindred. J Allergy Clin Immunol. 2010 Jul; 126(1):172-5.

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Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6256-61.

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Kawamura A, Baitsch D, Telgmann R, Feuerborn R, Weissen-Plenz G, Hagedorn C, Saku K, Brand-Herrmann SM, von Eckardstein A, Assmann G, Nofer JR. Apolipoprotein E interrupts interleukin-1beta signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2007 Jul; 27(7):1610-7.

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Boch JA, Yoshida Y, Koyama Y, Wara-Aswapati N, Peng H, Unlu S, Auron PE. Characterization of a cascade of protein interactions initiated at the IL-1 receptor. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):525-31.

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