Immunosuppressive Agents

"Immunosuppressive Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Descriptor ID	D007166
MeSH Number(s)	D27.505.696.477.656
Concept/Terms	Immunosuppressive Agents Immunosuppressive Agents Agents, Immunosuppressive Immunosuppressants

Below are MeSH descriptors whose meaning is more general than "Immunosuppressive Agents".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Physiological Effects of Drugs [D27.505.696]
Immunologic Factors [D27.505.696.477]
Immunosuppressive Agents [D27.505.696.477.656]

Below are MeSH descriptors whose meaning is related to "Immunosuppressive Agents".

Below are MeSH descriptors whose meaning is more specific than "Immunosuppressive Agents".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunosuppressive Agents" by people in this website by year, and whether "Immunosuppressive Agents" was a major or minor topic of these publications.

Bar chart showing 87 publications over 27 distinct years, with a maximum of 9 publications in 2001

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1999	0	1	1
2000	0	2	2
2001	5	4	9
2002	1	2	3
2003	2	4	6
2004	2	3	5
2005	3	1	4
2006	0	2	2
2007	0	2	2
2008	3	2	5
2009	4	2	6
2010	3	3	6
2011	1	1	2
2012	2	1	3
2013	1	1	2
2014	0	1	1
2015	3	1	4
2016	1	3	4
2017	0	1	1
2018	3	0	3
2019	2	2	4
2020	0	3	3
2021	3	1	4
2022	0	1	1
2023	0	1	1
2025	2	0	2

Below are the most recent publications written about "Immunosuppressive Agents" by people in Profiles.

Sabet H, Zanaty MA, Arafa A, El-Moslemani M, Olama SM, Saleh MGA, Abbas A, Obeidat AZ. Safety and effectiveness of diroximel fumarate in relapsing?forms of multiple sclerosis: a systematic review and meta-analysis. Neurol Sci. 2025 Aug; 46(8):3477-3490.

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Asare E, Du T, Xie H, Liang D, Gao S. Biopharmaceutical Factors Involved in the Disposition of Mycophenolic Acid: A Comprehensive Review of ADME Properties and Their Potential Impact on Mycophenolic Acid Plasma Exposure. Curr Drug Metab. 2025; 26(3):159-172.

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L?pez-Oliva MO, P?rez-Flores I, Molina M, Jos? Aladr?n M, Trujillo H, Redondo-Pach?n D, L?pez V, Facundo C, Villanego F, Rodr?guez M, Carmen Ruiz M, Ant?n P, Rivas-Oural A, Cabello S, Portol?s J, de la Vara L, Tabernero G, Valero R, Galeano C, Moral E, Ventura A, Coca A, ?ngel Mu?oz M, Hern?ndez-Gallego R, Shabaka A, Ledesma G, Bouarich H, ?ngeles Rodr?guez M, P?rez Tamaj?n L, Cruzado L, Emilio S?nchez J, Jim?nez C. Management of immunosuppressive therapy in kidney transplant recipients with COVID-19. A multicentre national study derived from the Spanish Society of Nephrology COVID registry. Nefrologia (Engl Ed). 2023 Jul-Aug; 43(4):442-451.

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Pascual J, Jim?nez C, Krajewska M, Seron D, Kotton CN, Portol?s J, Witzke O, Sorensen SS, Andr?s A, Crespo M, Paz-Artal E, D?ez T, Ortega A, Portero I. The Immunobiogram, a novel in vitro diagnostic test to measure the pharmacodynamic response to immunosuppressive therapy in kidney transplant patients. Transpl Immunol. 2022 12; 75:101711.

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Ghoneum M, El-Gerbed MSA. Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses. Cancer Chemother Pharmacol. 2021 12; 88(6):961-971.

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Hatano S, Matsuda S, Okanobu A, Furutama D, Memida T, Kajiya M, Ouhara K, Fujita T, Mizuno N, Kurihara H. The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth. FASEB J. 2021 07; 35(7):e21693.

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Martin-Moreno PL, S?nchez-Fructuoso AI, Mazuecos A, Mir M, Lopez-Lopez I, Gonz?lez-Rinne A, Coca A, Valero R, Ventura Galiano A, Ridao N, Toapanta-Gaibor NG, Fern?ndez-Tagarro E, Cruzado-Vega L, P?rez-Mir M, Jim?nez C. Paternal safety of the use of mycophenolic acid in kidney transplant recipients. Results of the EMVARON study. Clin Transplant. 2021 05; 35(5):e14256.

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Berkovich R, Yakupova A, Eskenazi J, Carlson NG, Steinman L. Improvement of Comorbid Psoriasis in Patients With MS Treated With Natalizumab. Neurol Neuroimmunol Neuroinflamm. 2021 03; 8(2).

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V?zquez-Otero I, Medina-Cintr?n N, Arroyo-?vila M, Gonz?lez-Sep?lveda L, Vil? LM. Clinical impact of hydroxychloroquine dose adjustment according to the American Academy of Ophthalmology guidelines in systemic lupus erythematosus. Lupus Sci Med. 2020 05; 7(1).

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L?pez V, V?zquez T, Alonso-Titos J, Cabello M, Alonso A, Beneyto I, Crespo M, D?az-Corte C, Franco A, Gonz?lez-Roncero F, Guti?rrez E, Guirado L, Jim?nez C, Jironda C, Lauzurica R, Llorente S, Mazuecos A, Paul J, Rodr?guez-Benot A, Ruiz JC, S?nchez-Fructuoso A, Sola E, Torregrosa V, Z?rraga S, Hern?ndez D. [Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients]. Nefrologia (Engl Ed). 2020 May - Jun; 40(3):265-271.

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