Mitogen-Activated Protein Kinases

"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

Descriptor ID	D020928
MeSH Number(s)	D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450
Concept/Terms	Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases Kinases, Mitogen-Activated Protein Mitogen Activated Protein Kinases Protein Kinases, Mitogen-Activated

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinases".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".

Mitogen-Activated Protein Kinases
Extracellular Signal-Regulated MAP Kinases
JNK Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.

Bar chart showing 112 publications over 26 distinct years, with a maximum of 17 publications in 2002 and 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	1	0	1
1998	4	0	4
1999	1	0	1
2000	3	3	6
2001	5	2	7
2002	7	10	17
2003	7	10	17
2004	1	6	7
2005	2	2	4
2006	2	3	5
2007	1	0	1
2008	2	6	8
2009	1	1	2
2010	1	2	3
2011	2	5	7
2012	3	0	3
2013	1	2	3
2014	3	2	5
2016	0	1	1
2017	0	1	1
2018	2	1	3
2019	0	1	1
2021	1	1	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.

Liu L, Wu Y, Liu K, Zhu M, Guang S, Wang F, Liu X, Yao X, He J, Fu C. The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions. Redox Biol. 2024 Jul; 73:103174.

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Patel JR, Banjara B, Ohemeng A, Davidson AM, Bou? SM, Burow ME, Tilghman SL. Novel Therapeutic Combination Targets the Growth of Letrozole-Resistant Breast Cancer through Decreased Cyclin B1. Nutrients. 2023 Mar 28; 15(7).

View in: PubMed
Li D, Liu Y, Yi P, Zhu Z, Li W, Zhang QC, Li JB, Ou G. RNA editing restricts hyperactive ciliary kinases. Science. 2021 08 27; 373(6558):984-991.

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Xie G, Zhu A, Gu X. Mitogen-activated protein kinase inhibition-induced modulation of epidermal growth factor receptor signaling in human head and neck squamous cell carcinoma. Head Neck. 2021 06; 43(6):1721-1729.

View in: PubMed
Santiago-Cartagena E, Gonz?lez-Crespo S, V?lez V, Mart?nez N, Snider J, Jessulat M, Aoki H, Minic Z, Akamine P, Mej?as I, P?rez LM, Rymond BC, Babu M, Stagljar I, Rodr?guez-Medina JR. Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. G3 (Bethesda). 2019 04 09; 9(4):1085-1102.

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Ghose R. Nature of the Pre-Chemistry Ensemble in Mitogen-Activated Protein Kinases. J Mol Biol. 2019 01 18; 431(2):145-157.

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Kumar S, Farah IO, Tchounwou PB. Trisenox induces cytotoxicity through phosphorylation of mitogen-activated protein kinase molecules in acute leukemia cells. J Biochem Mol Toxicol. 2018 Oct; 32(10):e22207.

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Dutta P, Sarkissyan M, Paico K, Wu Y, Vadgama JV. MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis. Breast Cancer Res Treat. 2018 Aug; 170(3):477-486.

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Montoya A, Amaya CN, Belmont A, Diab N, Trevino R, Villanueva G, Rains S, Sanchez LA, Badri N, Otoukesh S, Khammanivong A, Liss D, Baca ST, Aguilera RJ, Dickerson EB, Torabi A, Dwivedi AK, Abbas A, Chambers K, Bryan BA, Nahleh Z. Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget. 2017 Jan 24; 8(4):6446-6460.

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Pulliam SR, Pellom ST, Shanker A, Adunyah SE. Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine. 2016 08; 84:74-87.

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