p38 Mitogen-Activated Protein Kinases

"p38 Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.

Descriptor ID	D048051
MeSH Number(s)	D08.811.913.696.620.682.700.567.843 D12.644.360.450.835 D12.776.476.450.835
Concept/Terms	p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases p38 Mitogen Activated Protein Kinases p38 MAP Kinase MAP Kinase, p38 p38 MAPK MAPK, p38 p38 SAPK Mitogen-Activated Protein Kinase p38 Mitogen Activated Protein Kinase p38 p38 Protein Kinase Protein Kinase, p38

Below are MeSH descriptors whose meaning is more general than "p38 Mitogen-Activated Protein Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
p38 Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.843]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
p38 Mitogen-Activated Protein Kinases [D12.644.360.450.835]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
p38 Mitogen-Activated Protein Kinases [D12.776.476.450.835]

Below are MeSH descriptors whose meaning is related to "p38 Mitogen-Activated Protein Kinases".

Below are MeSH descriptors whose meaning is more specific than "p38 Mitogen-Activated Protein Kinases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "p38 Mitogen-Activated Protein Kinases" by people in this website by year, and whether "p38 Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.

Bar chart showing 89 publications over 25 distinct years, with a maximum of 7 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	2	2
2001	0	3	3
2002	0	4	4
2003	0	4	4
2004	1	4	5
2005	4	2	6
2006	0	4	4
2007	2	2	4
2008	0	2	2
2009	3	3	6
2010	0	6	6
2011	1	4	5
2012	1	1	2
2013	3	3	6
2014	0	3	3
2015	1	4	5
2016	2	5	7
2017	0	2	2
2018	0	2	2
2019	1	2	3
2020	0	2	2
2021	1	1	2
2022	0	1	1
2025	2	0	2

Below are the most recent publications written about "p38 Mitogen-Activated Protein Kinases" by people in Profiles.

Carlini MJ, Espinoza-Derout J, Van Alstyne M, Tisdale S, Workman E, Triplett MK, Tattoli I, Yadav S, Henderson CE, Watterson DM, Pellizzoni L. Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy. EMBO Mol Med. 2025 Oct; 17(10):2762-2786.

View in: PubMed
Abdou HM, Hamaad FA, Elmageed GMA, Katano H, Ghoneum MH. Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-?B and p38 MAPK Signaling Pathways. Oxid Med Cell Longev. 2025; 2025:3673280.

View in: PubMed
Liu Y, Liu R, Huang L, Zuo G, Dai J, Gao L, Shi H, Fang Y, Lu Q, Okada T, Wang Z, Hu X, Lenahan C, Tang J, Xiao J, Zhang JH. Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats. Oxid Med Cell Longev. 2022; 2022:7727616.

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Thakur V, Alcoreza N, Delgado M, Joddar B, Chattopadhyay M. Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats. Biomolecules. 2021 04 13; 11(4).

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Walker RR, Gallegos KM, Bratton MR, Lemieux KP, Zhang K, Wang G, Davidson AM, Tilghman SL. Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade. Anticancer Res. 2021 Feb; 41(2):583-599.

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Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419.

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Chen X, Hao A, Li X, Ye K, Zhao C, Yang H, Ma H, Hu L, Zhao Z, Hu L, Ye F, Sun Q, Zhang H, Wang H, Yao X, Fang Z. Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression. Theranostics. 2020; 10(3):998-1015.

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Costa Mendon?a-Natividade F, Duque Lopes C, Ricci-Azevedo R, Sardinha-Silva A, Figueiredo Pinzan C, Paiva Alegre-Maller AC, L Nohara L, B Carneiro A, Panunto-Castelo A, C Almeida I, Roque-Barreira MC. Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma gondii. Int J Mol Sci. 2019 Oct 10; 20(20).

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Ding Y, Flores J, Klebe D, Li P, McBride DW, Tang J, Zhang JH. Annexin A1 attenuates neuroinflammation through FPR2/p38/COX-2 pathway after intracerebral hemorrhage in male mice. J Neurosci Res. 2020 01; 98(1):168-178.

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Sampath C, Sprouse JC, Freeman ML, Gangula PR. Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice. Free Radic Biol Med. 2019 05 01; 135:132-143.

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