I-kappa B Kinase

"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

Descriptor ID	D051550
MeSH Number(s)	D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
Concept/Terms	I-kappa B Kinase I-kappa B Kinase B Kinase, I-kappa Kinase, I-kappa B NK-kappa B-Activating Kinase NAK NK kappa B Activating Kinase NAK IkappaB Kinase Kinase, IkappaB I kappa B Kinase IkappaB Kinase gamma IkappaB Kinase gamma IKK gamma NF-kappaB Essential Modifier Essential Modifier, NF-kappaB NF kappaB Essential Modifier IkappaB Kinase epsilon IkappaB Kinase epsilon Kinase epsilon, IkappaB IKK epsilon IKKepsilon IkappaB Kinase alpha IkappaB Kinase alpha Kinase alpha, IkappaB IKK 1 Kinase IKK alpha Conserved Helix-Loop-Helix Ubiquitous Kinase Conserved Helix Loop Helix Ubiquitous Kinase CHUK Kinase I Kappa B alpha-Associated Protein Kinase I Kappa B alpha Associated Protein Kinase IkappaBalpha Kinase IkappaB Kinase beta IkappaB Kinase beta Kinase beta, IkappaB IKK beta IKBKB IKK 2 Kinase

Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
I-kappa B Kinase [D12.644.360.361]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
I-kappa B Kinase [D12.776.476.378]

Below are MeSH descriptors whose meaning is related to "I-kappa B Kinase".

Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.

Bar chart showing 36 publications over 16 distinct years, with a maximum of 4 publications in 2005 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	0	2	2
2004	0	3	3
2005	2	2	4
2006	2	1	3
2008	1	0	1
2011	1	1	2
2012	1	1	2
2013	2	1	3
2014	3	1	4
2017	1	0	1
2018	1	0	1
2019	1	0	1
2020	1	0	1
2021	2	0	2
2022	1	2	3

Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.

Messeha SS, Zarmouh NO, Antonie L, Soliman KFA. Sanguinarine Inhibition of TNF-a-Induced CCL2, IKBKE/NF-?B/ERK1/2 Signaling Pathway, and Cell Migration in Human Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2022 Jul 28; 23(15).

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Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived a-methylene-?-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 06 01; 65:128713.

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Ko MS, Cohen SN, Polley S, Mahata SK, Biswas T, Huxford T, Ghosh G. Regulatory subunit NEMO promotes polyubiquitin-dependent induction of NF-?B through a targetable second interaction with upstream activator IKK2. J Biol Chem. 2022 05; 298(5):101864.

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Rizor A, Pajarillo E, Nyarko-Danquah I, Digman A, Mooneyham L, Son DS, Aschner M, Lee E. Manganese-induced reactive oxygen species activate I?B kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro. Neurotoxicology. 2021 09; 86:94-103.

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Napoleon JV, Singh S, Rana S, Bendjennat M, Kumar V, Kizhake S, Palermo NY, Ouellette MM, Huxford T, Natarajan A. Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner. Chem Commun (Camb). 2021 May 11; 57(38):4678-4681.

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Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochim Biophys Acta Proteins Proteom. 2020 12; 1868(12):140526.

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Mulero MC, Huxford T, Ghosh G. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226.

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House CD, Grajales V, Ozaki M, Jordan E, Wubneh H, Kimble DC, James JM, Kim MK, Annunziata CM. I??e cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts. BMC Cancer. 2018 May 25; 18(1):595.

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Bauer D, Redmon N, Mazzio E, Soliman KF. Apigenin inhibits TNFa/IL-1a-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. PLoS One. 2017; 12(4):e0175558.

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Chuang TD, Ho M, Khorram O. The regulatory function of miR-200c on inflammatory and cell-cycle associated genes in SK-LMS-1, a leiomyosarcoma cell line. Reprod Sci. 2015 May; 22(5):563-71.

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